Transdermal delivery of etidronate (EHDP) in the pig via iontophoresis
The delivery rate of etidronate disodium (EHDP) to a pig from an iontophoretic device placed on its back has been determined by comparing the plasma levels and amount on bone with the values obtained following an intravenous dose. A 5-cm 2 iontophoretic patch containing 9.8% EHDP and operating at a...
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| Veröffentlicht in: | Journal of membrane science 1988, Vol.35 (2), p.161-165 |
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| container_title | Journal of membrane science |
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| creator | Slough, C.L. Spinelli, M.J. Kasting, G.B. |
| description | The delivery rate of etidronate disodium (EHDP) to a pig from an iontophoretic device placed on its back has been determined by comparing the plasma levels and amount on bone with the values obtained following an intravenous dose. A 5-cm
2 iontophoretic patch containing 9.8% EHDP and operating at a current level of 4 mA delivered approximately 2 mg of drug in 1.1 hours. The peak plasma level resulting from this treatment was only 1.7% of that obtained from the intravenous infusion (6 mg). Elimination kinetics of the drug after cessation of the treatment paralleled those obtained in the intravenous study. The amount of drug delivered was consistent with a prediction based on iontophoretic transport of EHDP through skin
in vitro. |
| doi_str_mv | 10.1016/S0376-7388(00)82441-2 |
| format | Article |
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2 iontophoretic patch containing 9.8% EHDP and operating at a current level of 4 mA delivered approximately 2 mg of drug in 1.1 hours. The peak plasma level resulting from this treatment was only 1.7% of that obtained from the intravenous infusion (6 mg). Elimination kinetics of the drug after cessation of the treatment paralleled those obtained in the intravenous study. The amount of drug delivered was consistent with a prediction based on iontophoretic transport of EHDP through skin
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2 iontophoretic patch containing 9.8% EHDP and operating at a current level of 4 mA delivered approximately 2 mg of drug in 1.1 hours. The peak plasma level resulting from this treatment was only 1.7% of that obtained from the intravenous infusion (6 mg). Elimination kinetics of the drug after cessation of the treatment paralleled those obtained in the intravenous study. The amount of drug delivered was consistent with a prediction based on iontophoretic transport of EHDP through skin
in vitro.</description><subject>Biological and medical sciences</subject><subject>etidronic acid</subject><subject>General pharmacology</subject><subject>iontophoresis</subject><subject>Medical sciences</subject><subject>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</subject><subject>Pharmacology. Drug treatments</subject><subject>skin</subject><issn>0376-7388</issn><issn>1873-3123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><recordid>eNqFkE1Lw0AQhhdRsFZ_grAHkfYQnc0m2c1JpLZWKChYz8tmM7ErabbupoX-e9MPevU0l-edd-Yh5JbBAwOWPX4CF1kkuJQDgKGMk4RF8RnpMSl4xFnMz0nvhFySqxB-AJgAmffIZO51E0r0S13TEmu7Qb-lrqLY2tK7RrdIB-Ppy8eQ2oa2C6Qr-003VlPrmtatFs5jsOGaXFS6DnhznH3yNRnPR9No9v76NnqeRYZnoo2MKLDkvDAAueFc8ypLc50UpUw5E0UGaAwWoLujC8kSgzIxOQiBLIU0h5L3yf1h78q73zWGVi1tMFjXukG3DoolMs5ZlnRgegCNdyF4rNTK26X2W8VA7aypvTW1U6IA1N6airvc3bFAB6PrqrNjbDiFhYiFTPIOezpg2D27sehVMBYbg6X1aFpVOvtP0R87m4BH</recordid><startdate>1988</startdate><enddate>1988</enddate><creator>Slough, C.L.</creator><creator>Spinelli, M.J.</creator><creator>Kasting, G.B.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>M7Z</scope><scope>P64</scope></search><sort><creationdate>1988</creationdate><title>Transdermal delivery of etidronate (EHDP) in the pig via iontophoresis</title><author>Slough, C.L. ; Spinelli, M.J. ; Kasting, G.B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c367t-c7bed33bc009c33a3f659a4bd85317b60ecceb0a312b814ce84c9077e150590d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Biological and medical sciences</topic><topic>etidronic acid</topic><topic>General pharmacology</topic><topic>iontophoresis</topic><topic>Medical sciences</topic><topic>Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions</topic><topic>Pharmacology. Drug treatments</topic><topic>skin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Slough, C.L.</creatorcontrib><creatorcontrib>Spinelli, M.J.</creatorcontrib><creatorcontrib>Kasting, G.B.</creatorcontrib><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of membrane science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Slough, C.L.</au><au>Spinelli, M.J.</au><au>Kasting, G.B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Transdermal delivery of etidronate (EHDP) in the pig via iontophoresis</atitle><jtitle>Journal of membrane science</jtitle><date>1988</date><risdate>1988</risdate><volume>35</volume><issue>2</issue><spage>161</spage><epage>165</epage><pages>161-165</pages><issn>0376-7388</issn><eissn>1873-3123</eissn><coden>JMESDO</coden><abstract>The delivery rate of etidronate disodium (EHDP) to a pig from an iontophoretic device placed on its back has been determined by comparing the plasma levels and amount on bone with the values obtained following an intravenous dose. A 5-cm
2 iontophoretic patch containing 9.8% EHDP and operating at a current level of 4 mA delivered approximately 2 mg of drug in 1.1 hours. The peak plasma level resulting from this treatment was only 1.7% of that obtained from the intravenous infusion (6 mg). Elimination kinetics of the drug after cessation of the treatment paralleled those obtained in the intravenous study. The amount of drug delivered was consistent with a prediction based on iontophoretic transport of EHDP through skin
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| ispartof | Journal of membrane science, 1988, Vol.35 (2), p.161-165 |
| issn | 0376-7388 1873-3123 |
| language | eng |
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| source | Access via ScienceDirect (Elsevier) |
| subjects | Biological and medical sciences etidronic acid General pharmacology iontophoresis Medical sciences Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology. Drug treatments skin |
| title | Transdermal delivery of etidronate (EHDP) in the pig via iontophoresis |
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