Adriamycin cardiotoxicity and proton nuclear magnetic resonance relaxation properties
Present noninvasive techniques to detect Adriamycin (doxorubicin) cardiotoxicity rely on assessment of myocardial function rather than direct observation of change in tissue character. Proton nuclear magnetic resonance imaging may provide a unique means of characterizing the myocardium. The relaxati...
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| Veröffentlicht in: | The American heart journal 1987-06, Vol.113 (6), p.1444-1449 |
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| container_end_page | 1449 |
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| container_issue | 6 |
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| container_title | The American heart journal |
| container_volume | 113 |
| creator | Thompson, Randall C. Canby, Robert C. Lojeski, Edwin W. Ratner, Adam V. Fallon, John T. Pohost, Gerald M. |
| description | Present noninvasive techniques to detect Adriamycin (doxorubicin) cardiotoxicity rely on assessment of myocardial function rather than direct observation of change in tissue character. Proton nuclear magnetic resonance imaging may provide a unique means of characterizing the myocardium. The relaxation properties T1 and T2 are related to certain biophysical properties of tissue such as water, lipid, and macromolecular content and have considerable impact on the intensity observed in nuclear magnetic resonance images. In a model of chronic Adriamycin cardiotoxicity in rats, T1 values of excised hearts were elevated, relative to control, in rats with histologic evidence of chronic cardiotoxicity (651 msec vs 622 msec, p < 0.05) and more so in rats with gross evidence of toxicity or heart failure (668 msec, p |
| doi_str_mv | 10.1016/0002-8703(87)90660-0 |
| format | Article |
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Proton nuclear magnetic resonance imaging may provide a unique means of characterizing the myocardium. The relaxation properties T1 and T2 are related to certain biophysical properties of tissue such as water, lipid, and macromolecular content and have considerable impact on the intensity observed in nuclear magnetic resonance images. In a model of chronic Adriamycin cardiotoxicity in rats, T1 values of excised hearts were elevated, relative to control, in rats with histologic evidence of chronic cardiotoxicity (651 msec vs 622 msec, p < 0.05) and more so in rats with gross evidence of toxicity or heart failure (668 msec, p<0.005). No significant change in T2 was observed. This T1 prolongation increases as disease worsens, whereas water concentration did not change significantly. The results suggest that predictable prolongation in T1 occurs in association with cardiotoxicity. In conclusion, proton nuclear magnetic resonance imaging methods could provide a new means for assessing Adriamycin cardiotoxicity.</description><identifier>ISSN: 0002-8703</identifier><identifier>EISSN: 1097-6744</identifier><identifier>DOI: 10.1016/0002-8703(87)90660-0</identifier><identifier>PMID: 3591613</identifier><identifier>CODEN: AHJOA2</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Doxorubicin - poisoning ; Drug toxicity and drugs side effects treatment ; Heart - drug effects ; Heart Failure - chemically induced ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; Myocardial Contraction - drug effects ; Myocardium - pathology ; Organ Size ; Pharmacology. 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Proton nuclear magnetic resonance imaging may provide a unique means of characterizing the myocardium. The relaxation properties T1 and T2 are related to certain biophysical properties of tissue such as water, lipid, and macromolecular content and have considerable impact on the intensity observed in nuclear magnetic resonance images. In a model of chronic Adriamycin cardiotoxicity in rats, T1 values of excised hearts were elevated, relative to control, in rats with histologic evidence of chronic cardiotoxicity (651 msec vs 622 msec, p < 0.05) and more so in rats with gross evidence of toxicity or heart failure (668 msec, p<0.005). No significant change in T2 was observed. This T1 prolongation increases as disease worsens, whereas water concentration did not change significantly. The results suggest that predictable prolongation in T1 occurs in association with cardiotoxicity. In conclusion, proton nuclear magnetic resonance imaging methods could provide a new means for assessing Adriamycin cardiotoxicity.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Doxorubicin - poisoning</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Heart - drug effects</subject><subject>Heart Failure - chemically induced</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myocardial Contraction - drug effects</subject><subject>Myocardium - pathology</subject><subject>Organ Size</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred F344</subject><subject>Toxicity: cardiovascular system</subject><issn>0002-8703</issn><issn>1097-6744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtrGzEQgEVJSJ3HP2hhD6Gkh001q11p9xIIIWkDhlyasxhJo6KyD0daF_vfV46Nj7loNMw3Dz7GvgC_BQ7yB-e8KlvFxU2rvndcSl7yT2wBvFOlVHV9whZH5DM7T-lvTmXVyjN2JpoOJIgFe713MeCwtWEsLEYXpnnaBBvmbYGjK1Yx52Mxrm1PGIsB_4w0B1tEStOIo6X863GDc8hUhlcU50Dpkp167BNdHeIFe316_P3wq1y-_Hx-uF-Wtm7FXDYWyCMXYKRxHXUejPIGG9eaipwVlkODgNhxISU04BtQCjpjWu-lMkJcsG_7uXn125rSrIeQLPU9jjStk4a6rRpVyQzWe9DGKaVIXq9iGDBuNXC9s6l3qvROVX70u03Nc9vXw_y1Gcgdmw76cv36UMdksfcxKwnpiKkalHjH7vYYZRf_AkWdbKBsz4VIdtZuCh_f8R8hxZJl</recordid><startdate>19870601</startdate><enddate>19870601</enddate><creator>Thompson, Randall C.</creator><creator>Canby, Robert C.</creator><creator>Lojeski, Edwin W.</creator><creator>Ratner, Adam V.</creator><creator>Fallon, John T.</creator><creator>Pohost, Gerald M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19870601</creationdate><title>Adriamycin cardiotoxicity and proton nuclear magnetic resonance relaxation properties</title><author>Thompson, Randall C. ; Canby, Robert C. ; Lojeski, Edwin W. ; Ratner, Adam V. ; Fallon, John T. ; Pohost, Gerald M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-5c1efa031b6bd9e9f1b7fba5d8b2edc3c015a1aa90366151f517719bb8ff67b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Doxorubicin - poisoning</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Heart - drug effects</topic><topic>Heart Failure - chemically induced</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Myocardial Contraction - drug effects</topic><topic>Myocardium - pathology</topic><topic>Organ Size</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred F344</topic><topic>Toxicity: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Thompson, Randall C.</creatorcontrib><creatorcontrib>Canby, Robert C.</creatorcontrib><creatorcontrib>Lojeski, Edwin W.</creatorcontrib><creatorcontrib>Ratner, Adam V.</creatorcontrib><creatorcontrib>Fallon, John T.</creatorcontrib><creatorcontrib>Pohost, Gerald M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>The American heart journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Thompson, Randall C.</au><au>Canby, Robert C.</au><au>Lojeski, Edwin W.</au><au>Ratner, Adam V.</au><au>Fallon, John T.</au><au>Pohost, Gerald M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adriamycin cardiotoxicity and proton nuclear magnetic resonance relaxation properties</atitle><jtitle>The American heart journal</jtitle><addtitle>Am Heart J</addtitle><date>1987-06-01</date><risdate>1987</risdate><volume>113</volume><issue>6</issue><spage>1444</spage><epage>1449</epage><pages>1444-1449</pages><issn>0002-8703</issn><eissn>1097-6744</eissn><coden>AHJOA2</coden><abstract>Present noninvasive techniques to detect Adriamycin (doxorubicin) cardiotoxicity rely on assessment of myocardial function rather than direct observation of change in tissue character. Proton nuclear magnetic resonance imaging may provide a unique means of characterizing the myocardium. The relaxation properties T1 and T2 are related to certain biophysical properties of tissue such as water, lipid, and macromolecular content and have considerable impact on the intensity observed in nuclear magnetic resonance images. In a model of chronic Adriamycin cardiotoxicity in rats, T1 values of excised hearts were elevated, relative to control, in rats with histologic evidence of chronic cardiotoxicity (651 msec vs 622 msec, p < 0.05) and more so in rats with gross evidence of toxicity or heart failure (668 msec, p<0.005). No significant change in T2 was observed. This T1 prolongation increases as disease worsens, whereas water concentration did not change significantly. The results suggest that predictable prolongation in T1 occurs in association with cardiotoxicity. In conclusion, proton nuclear magnetic resonance imaging methods could provide a new means for assessing Adriamycin cardiotoxicity.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3591613</pmid><doi>10.1016/0002-8703(87)90660-0</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Biological and medical sciences Doxorubicin - poisoning Drug toxicity and drugs side effects treatment Heart - drug effects Heart Failure - chemically induced Magnetic Resonance Spectroscopy Male Medical sciences Myocardial Contraction - drug effects Myocardium - pathology Organ Size Pharmacology. Drug treatments Rats Rats, Inbred F344 Toxicity: cardiovascular system |
| title | Adriamycin cardiotoxicity and proton nuclear magnetic resonance relaxation properties |
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