Type II collagen arthritis: Identification of arthritogenic epitopes using fractionated anticollagen IgG
Affinity-purified anticollagen IgG was fractionated on purified cyanogen bromide-derived collagen peptide Sepharose. The antibody fraction bound to the peptides was eluted and tested for its ability to induce passive arthritis in recipients. Anticollagen IgG bound to peptide 5 ( α 1( II)-CB 8–10 and...
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| Veröffentlicht in: | Cellular immunology 1987-04, Vol.105 (2), p.447-453 |
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| container_end_page | 453 |
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| container_issue | 2 |
| container_start_page | 447 |
| container_title | Cellular immunology |
| container_volume | 105 |
| creator | Englert, Mary E. Ferguson, Kim M. Suarez, Carmen R. Sapp, Theresa M. Oronsky, Arnold L. Kerwar, S.S. |
| description | Affinity-purified anticollagen IgG was fractionated on purified cyanogen bromide-derived collagen peptide Sepharose. The antibody fraction bound to the peptides was eluted and tested for its ability to induce passive arthritis in recipients. Anticollagen IgG bound to peptide 5 (
α
1(
II)-CB
8–10 and
α
1(
II)CB
11−8) and to peptide 6 (
α
1(
II)CB
11) were active in inducing passive arthritis. Other peptide bound fractions were inactive. These observations suggest that the arthritogenic domain in Type II collagen is restricted to
α
1(
II)CB
11. |
| doi_str_mv | 10.1016/0008-8749(87)90092-X |
| format | Article |
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α
1(
II)-CB
8–10 and
α
1(
II)CB
11−8) and to peptide 6 (
α
1(
II)CB
11) were active in inducing passive arthritis. Other peptide bound fractions were inactive. These observations suggest that the arthritogenic domain in Type II collagen is restricted to
α
1(
II)CB
11.</description><identifier>ISSN: 0008-8749</identifier><identifier>EISSN: 1090-2163</identifier><identifier>DOI: 10.1016/0008-8749(87)90092-X</identifier><identifier>PMID: 2436812</identifier><identifier>CODEN: CLIMB8</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Amino Acids - analysis ; Animals ; Antibodies - administration & dosage ; Antibodies - immunology ; Antibodies - isolation & purification ; Arthritis - immunology ; Arthritis, Experimental - chemically induced ; Arthritis, Experimental - immunology ; Biological and medical sciences ; Cartilage - immunology ; Chromatography, Affinity - methods ; Collagen - immunology ; Cyanogen Bromide - pharmacology ; Epitopes - analysis ; Epitopes - immunology ; Fluorescent Antibody Technique ; Fundamental and applied biological sciences. Psychology ; Immunoglobulin G - administration & dosage ; Inflammation ; Male ; Molecular and cellular biology ; Peptides - immunology ; Peptides - isolation & purification ; Protein Conformation ; Rats ; Rats, Inbred Strains</subject><ispartof>Cellular immunology, 1987-04, Vol.105 (2), p.447-453</ispartof><rights>1987</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-13144b57e493dc104423564527a59801cf3d4cd6a0b65cd298c166b4e582c56e3</citedby><cites>FETCH-LOGICAL-c417t-13144b57e493dc104423564527a59801cf3d4cd6a0b65cd298c166b4e582c56e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/000887498790092X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7406036$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2436812$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Englert, Mary E.</creatorcontrib><creatorcontrib>Ferguson, Kim M.</creatorcontrib><creatorcontrib>Suarez, Carmen R.</creatorcontrib><creatorcontrib>Sapp, Theresa M.</creatorcontrib><creatorcontrib>Oronsky, Arnold L.</creatorcontrib><creatorcontrib>Kerwar, S.S.</creatorcontrib><title>Type II collagen arthritis: Identification of arthritogenic epitopes using fractionated anticollagen IgG</title><title>Cellular immunology</title><addtitle>Cell Immunol</addtitle><description>Affinity-purified anticollagen IgG was fractionated on purified cyanogen bromide-derived collagen peptide Sepharose. The antibody fraction bound to the peptides was eluted and tested for its ability to induce passive arthritis in recipients. Anticollagen IgG bound to peptide 5 (
α
1(
II)-CB
8–10 and
α
1(
II)CB
11−8) and to peptide 6 (
α
1(
II)CB
11) were active in inducing passive arthritis. Other peptide bound fractions were inactive. These observations suggest that the arthritogenic domain in Type II collagen is restricted to
α
1(
II)CB
11.</description><subject>Amino Acids - analysis</subject><subject>Animals</subject><subject>Antibodies - administration & dosage</subject><subject>Antibodies - immunology</subject><subject>Antibodies - isolation & purification</subject><subject>Arthritis - immunology</subject><subject>Arthritis, Experimental - chemically induced</subject><subject>Arthritis, Experimental - immunology</subject><subject>Biological and medical sciences</subject><subject>Cartilage - immunology</subject><subject>Chromatography, Affinity - methods</subject><subject>Collagen - immunology</subject><subject>Cyanogen Bromide - pharmacology</subject><subject>Epitopes - analysis</subject><subject>Epitopes - immunology</subject><subject>Fluorescent Antibody Technique</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunoglobulin G - administration & dosage</subject><subject>Inflammation</subject><subject>Male</subject><subject>Molecular and cellular biology</subject><subject>Peptides - immunology</subject><subject>Peptides - isolation & purification</subject><subject>Protein Conformation</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0008-8749</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFqGzEQhkVJcRynb9CCDqGkh21GWq12N4dAMUm6EOglBd-EPJp1FOzdjbQu-O0r146PvWgE__cPw8fYZwHfBQh9AwBVVpWqvq7KbzVALbPFBzYVUEMmhc7P2PSEnLOLGF8BhFA1TNhEqlxXQk7Zy_NuIN40HPv12q6o4zaML8GPPt7yxlE3-tajHX3f8b59D_sEeuQ0pO9AkW-j71a8DRb3oB3JcZuap53N6vGSfWztOtKn45yx3w_3z_Of2dOvx2b-4ylDJcoxE7lQalmUpOrcoQClZF5oVcjSFnUFAtvcKXTawlIX6GRdodB6qaioJBaa8hn7etg7hP5tS3E0Gx-R0iEd9dtohKqkkoVMoDqAGPoYA7VmCH5jw84IMHvBZm_P7O2lx_wTbBap9uW4f7vckDuVjkZTfnXMbUS7Tk469PGElQo05DphdweMkos_noKJ6KlDcj4Qjsb1_v93_AVInZd0</recordid><startdate>19870401</startdate><enddate>19870401</enddate><creator>Englert, Mary E.</creator><creator>Ferguson, Kim M.</creator><creator>Suarez, Carmen R.</creator><creator>Sapp, Theresa M.</creator><creator>Oronsky, Arnold L.</creator><creator>Kerwar, S.S.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>19870401</creationdate><title>Type II collagen arthritis: Identification of arthritogenic epitopes using fractionated anticollagen IgG</title><author>Englert, Mary E. ; Ferguson, Kim M. ; Suarez, Carmen R. ; Sapp, Theresa M. ; Oronsky, Arnold L. ; Kerwar, S.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-13144b57e493dc104423564527a59801cf3d4cd6a0b65cd298c166b4e582c56e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Amino Acids - analysis</topic><topic>Animals</topic><topic>Antibodies - administration & dosage</topic><topic>Antibodies - immunology</topic><topic>Antibodies - isolation & purification</topic><topic>Arthritis - immunology</topic><topic>Arthritis, Experimental - chemically induced</topic><topic>Arthritis, Experimental - immunology</topic><topic>Biological and medical sciences</topic><topic>Cartilage - immunology</topic><topic>Chromatography, Affinity - methods</topic><topic>Collagen - immunology</topic><topic>Cyanogen Bromide - pharmacology</topic><topic>Epitopes - analysis</topic><topic>Epitopes - immunology</topic><topic>Fluorescent Antibody Technique</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunoglobulin G - administration & dosage</topic><topic>Inflammation</topic><topic>Male</topic><topic>Molecular and cellular biology</topic><topic>Peptides - immunology</topic><topic>Peptides - isolation & purification</topic><topic>Protein Conformation</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Englert, Mary E.</creatorcontrib><creatorcontrib>Ferguson, Kim M.</creatorcontrib><creatorcontrib>Suarez, Carmen R.</creatorcontrib><creatorcontrib>Sapp, Theresa M.</creatorcontrib><creatorcontrib>Oronsky, Arnold L.</creatorcontrib><creatorcontrib>Kerwar, S.S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Englert, Mary E.</au><au>Ferguson, Kim M.</au><au>Suarez, Carmen R.</au><au>Sapp, Theresa M.</au><au>Oronsky, Arnold L.</au><au>Kerwar, S.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Type II collagen arthritis: Identification of arthritogenic epitopes using fractionated anticollagen IgG</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>1987-04-01</date><risdate>1987</risdate><volume>105</volume><issue>2</issue><spage>447</spage><epage>453</epage><pages>447-453</pages><issn>0008-8749</issn><eissn>1090-2163</eissn><coden>CLIMB8</coden><abstract>Affinity-purified anticollagen IgG was fractionated on purified cyanogen bromide-derived collagen peptide Sepharose. The antibody fraction bound to the peptides was eluted and tested for its ability to induce passive arthritis in recipients. Anticollagen IgG bound to peptide 5 (
α
1(
II)-CB
8–10 and
α
1(
II)CB
11−8) and to peptide 6 (
α
1(
II)CB
11) were active in inducing passive arthritis. Other peptide bound fractions were inactive. These observations suggest that the arthritogenic domain in Type II collagen is restricted to
α
1(
II)CB
11.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>2436812</pmid><doi>10.1016/0008-8749(87)90092-X</doi><tpages>7</tpages></addata></record> |
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| ispartof | Cellular immunology, 1987-04, Vol.105 (2), p.447-453 |
| issn | 0008-8749 1090-2163 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14824252 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Amino Acids - analysis Animals Antibodies - administration & dosage Antibodies - immunology Antibodies - isolation & purification Arthritis - immunology Arthritis, Experimental - chemically induced Arthritis, Experimental - immunology Biological and medical sciences Cartilage - immunology Chromatography, Affinity - methods Collagen - immunology Cyanogen Bromide - pharmacology Epitopes - analysis Epitopes - immunology Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Immunoglobulin G - administration & dosage Inflammation Male Molecular and cellular biology Peptides - immunology Peptides - isolation & purification Protein Conformation Rats Rats, Inbred Strains |
| title | Type II collagen arthritis: Identification of arthritogenic epitopes using fractionated anticollagen IgG |
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