Mouse bone marrow-derived mast cells cocultured with fibroblasts. Morphology and stimulation-induced release of histamine, leukotriene B sub(4), leukotriene C sub(4), and prostaglandin D sub(2)
Mouse bone marrow-derived mast cells (BMMC), cultured for 2, 7, of 14 days in WEHI-3 conditioned medium in the absence or presence of mouse 3T3 fibroblasts, were examined morphologically and for their functional responses to IgE-Fc-mediated and calcium ionophore-mediated activation. Coculture of BMM...
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| Veröffentlicht in: | The Journal of immunology (1950) 1987-01, Vol.139 (10), p.3431-3441 |
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| container_issue | 10 |
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| container_title | The Journal of immunology (1950) |
| container_volume | 139 |
| creator | Levi-Schaffer, F Dayton, E T Austen, K F Hein, A Caulfield, J P Gravallese, P M Liu, F-T Stevens, R L |
| description | Mouse bone marrow-derived mast cells (BMMC), cultured for 2, 7, of 14 days in WEHI-3 conditioned medium in the absence or presence of mouse 3T3 fibroblasts, were examined morphologically and for their functional responses to IgE-Fc-mediated and calcium ionophore-mediated activation. Coculture of BMMC with fibroblasts induces an alteration in the composition of the secretory granules of the mast cells, as well as an augmentation of the activation-secretion response of the BMMC. The latter property requires that juxtaposition be maintained between the two cell types. |
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| ispartof | The Journal of immunology (1950), 1987-01, Vol.139 (10), p.3431-3441 |
| issn | 0022-1767 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14822997 |
| source | Alma/SFX Local Collection |
| title | Mouse bone marrow-derived mast cells cocultured with fibroblasts. Morphology and stimulation-induced release of histamine, leukotriene B sub(4), leukotriene C sub(4), and prostaglandin D sub(2) |
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