Cytochrome P-450 dependent binding of methapyrilene to DNA in vitro

Methapyrilene ([14C]MHP) was found to bind to calf thymus DNA only after activation by both rat liver microsomes and NADPH. The cytochrome P-450 inhibitors 2,4-dichloro-6-phenylphenoxyethylamine, 2-diethylaminoethyl-2,2-diphenyl-valerate and metyrapone inhibited binding, but methimazole, a flavin-de...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Carcinogenesis (New York) 1987-10, Vol.8 (10), p.1525-1529
Hauptverfasser:	Lampe, M.A., Kammerer, R.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine - pharmacology Aminopyridines - metabolism Animals Biological and medical sciences Biotransformation Cattle Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism DNA - metabolism Fundamental and applied biological sciences. Psychology Methapyrilene - metabolism Methimazole - pharmacology Metyrapone - pharmacology Microsomes, Liver - enzymology Microsomes, Liver - metabolism Molecular and cellular biology Molecular genetics Mutagenesis. Repair NADP - metabolism Phenobarbital - pharmacology Polychlorinated Biphenyls - pharmacology Pregnenolone Carbonitrile - pharmacology Proadifen - pharmacology Rats Safrole - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!