Tight agonist binding may prevent the correct interpretation of agonist competition binding curves for alpha sub(2)-adrenergic receptors

alpha sub(2)-Adrenergic receptors in calf retina membranes can be specifically labeled with the tritiated antagonist super(3)H-RX 781094. Saturation binding occurs to a single class of noncooperative sites. The findings are confirmed by kinetic experiments using the radiolabeled agonist super(3)H-UK...

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Veröffentlicht in:	Molecular pharmacology 1987-01, Vol.32 (1), p.65-72
Hauptverfasser:	Convents, A, De Backer, J-P, Convents, D, Vauquelin, G
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha 2-adrenergic retina
Online-Zugang:	Volltext
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