Combination antiangiogenic therapy and radiation in head and neck cancers

Summary Tumor angiogenesis is a hallmark of advanced cancers and promotes invasion and metastasis. Over 90% of head and neck squamous cell carcinomas (HNSCC) express angiogenic factors such as vascular endothelial growth factor (VEGF). Several preclinical studies support the prognostic implications...

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Veröffentlicht in:	Oral oncology 2014-01, Vol.50 (1), p.19-26
Hauptverfasser:	Hsu, Heng-Wei, Wall, Nathan R, Hsueh, Chung-Tsen, Kim, Seungwon, Ferris, Robert L, Chen, Chien-Shing, Mirshahidi, Saied
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Inhibitors - therapeutic use Antiangiogenesis Biological and medical sciences Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - therapy Combined Modality Therapy Comibination therapy DNA damage Head and neck cancer Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - radiotherapy Head and Neck Neoplasms - therapy Hematology, Oncology and Palliative Medicine Humans Medical sciences Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Otolaryngology Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Radiation Targeted therapy Tumors VEGFR/PDGFR inhibitor
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