A3 Adenosine receptors mediate oligodendrocyte death and ischemic damage to optic nerve

Adenosine receptor activation is involved in myelination and in apoptotic pathways linked to neurodegenerative diseases. In this study, we investigated the effects of adenosine receptor activation in the viability of oligodendrocytes of the rat optic nerve. Selective activation of A3 receptors in pu...

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Veröffentlicht in:	Glia 2014-02, Vol.62 (2), p.199-216
Hauptverfasser:	González-Fernández, Estíbaliz, Sánchez-Gómez, María Victoria, Pérez-Samartín, Alberto, Arellano, Rogelio O., Matute, Carlos
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine - analogs & derivatives Adenosine - pharmacology Adenosine A3 Receptor Agonists - administration & dosage Adenosine A3 Receptor Agonists - pharmacology Animals Apoptosis - drug effects astrocytes Caspase 3 - metabolism caspases Cells, Cultured demyelinization ischemia mitochondria Oligodendroglia - cytology Oligodendroglia - metabolism Optic nerve Optic Nerve - metabolism Rats Rats, Sprague-Dawley Receptor, Adenosine A3 - metabolism Rodents
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