Genetic parameters for birthweight environmental variability in mice
Summary Data from a divergent experiment for birthweight (BrW) environmental variability were used to estimate genetic parameters for BrW trait and its environmental variability by fitting both homoscedastic (HO) and heteroscedastic (HE) models. A total of 5 475 records of BrW from animals born from...
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| Veröffentlicht in: | Journal of animal breeding and genetics (1986) 2013-10, Vol.130 (5), p.404-414 |
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| container_title | Journal of animal breeding and genetics (1986) |
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| creator | Pun, A. Cervantes, I. Nieto, B. Salgado, C. Pérez-Cabal, M.A. Ibáñez-Escriche, N. Gutiérrez, J.P. |
| description | Summary
Data from a divergent experiment for birthweight (BrW) environmental variability were used to estimate genetic parameters for BrW trait and its environmental variability by fitting both homoscedastic (HO) and heteroscedastic (HE) models. A total of 5 475 records of BrW from animals born from inbred dams, and 7 140 pedigree records were used. The heritability of BrW using the model HO was 0.27, with the litter effect much more important, 0.43. The model HE provided a genetic correlation between the trait and its environmental variability that was very high and negative, −0.97, and a high value for the additive genetic variance for environmental variability, suggesting an artefact in the model. The residual skewness was found to be essentially null. A model considering the genetic correlation null was also fitted, and used to obtain the breeding values for the selection process. Moreover, the trait was considered as maternal resulting in similar estimates under the model HO, but more reasonable for the genetic correlation between the trait and its environmental variability of 0.48 with a value of 0.25 for the additive genetic variance regarding environmental variability under the model HE. This led to the conclusion that environmental variability of BrW in mice must be selected via dams. Estimated parameters in a reduced dataset without inbred animals did not substantially change this conclusion. |
| doi_str_mv | 10.1111/jbg.12021 |
| format | Article |
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Data from a divergent experiment for birthweight (BrW) environmental variability were used to estimate genetic parameters for BrW trait and its environmental variability by fitting both homoscedastic (HO) and heteroscedastic (HE) models. A total of 5 475 records of BrW from animals born from inbred dams, and 7 140 pedigree records were used. The heritability of BrW using the model HO was 0.27, with the litter effect much more important, 0.43. The model HE provided a genetic correlation between the trait and its environmental variability that was very high and negative, −0.97, and a high value for the additive genetic variance for environmental variability, suggesting an artefact in the model. The residual skewness was found to be essentially null. A model considering the genetic correlation null was also fitted, and used to obtain the breeding values for the selection process. Moreover, the trait was considered as maternal resulting in similar estimates under the model HO, but more reasonable for the genetic correlation between the trait and its environmental variability of 0.48 with a value of 0.25 for the additive genetic variance regarding environmental variability under the model HE. This led to the conclusion that environmental variability of BrW in mice must be selected via dams. Estimated parameters in a reduced dataset without inbred animals did not substantially change this conclusion.</description><identifier>ISSN: 0931-2668</identifier><identifier>EISSN: 1439-0388</identifier><identifier>DOI: 10.1111/jbg.12021</identifier><identifier>PMID: 24074177</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Animal reproduction ; Animals ; Birth weight ; Birth Weight - genetics ; Birthweight ; canalization ; Environment ; environmental variability ; Female ; genetic correlation ; Genetics ; Inbreeding ; Male ; Mice ; Models, Genetic ; Mothers ; Rodents</subject><ispartof>Journal of animal breeding and genetics (1986), 2013-10, Vol.130 (5), p.404-414</ispartof><rights>2012 Blackwell Verlag GmbH</rights><rights>2012 Blackwell Verlag GmbH.</rights><rights>Copyright © 2013 Blackwell Verlag GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4241-c3d29c5d6f5dc078648e345a9eefe3962c42bbd88d23b986c7d3d68d059834883</citedby><cites>FETCH-LOGICAL-c4241-c3d29c5d6f5dc078648e345a9eefe3962c42bbd88d23b986c7d3d68d059834883</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjbg.12021$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjbg.12021$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24074177$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pun, A.</creatorcontrib><creatorcontrib>Cervantes, I.</creatorcontrib><creatorcontrib>Nieto, B.</creatorcontrib><creatorcontrib>Salgado, C.</creatorcontrib><creatorcontrib>Pérez-Cabal, M.A.</creatorcontrib><creatorcontrib>Ibáñez-Escriche, N.</creatorcontrib><creatorcontrib>Gutiérrez, J.P.</creatorcontrib><title>Genetic parameters for birthweight environmental variability in mice</title><title>Journal of animal breeding and genetics (1986)</title><addtitle>J. Anim. Breed. Genet</addtitle><description>Summary
Data from a divergent experiment for birthweight (BrW) environmental variability were used to estimate genetic parameters for BrW trait and its environmental variability by fitting both homoscedastic (HO) and heteroscedastic (HE) models. A total of 5 475 records of BrW from animals born from inbred dams, and 7 140 pedigree records were used. The heritability of BrW using the model HO was 0.27, with the litter effect much more important, 0.43. The model HE provided a genetic correlation between the trait and its environmental variability that was very high and negative, −0.97, and a high value for the additive genetic variance for environmental variability, suggesting an artefact in the model. The residual skewness was found to be essentially null. A model considering the genetic correlation null was also fitted, and used to obtain the breeding values for the selection process. Moreover, the trait was considered as maternal resulting in similar estimates under the model HO, but more reasonable for the genetic correlation between the trait and its environmental variability of 0.48 with a value of 0.25 for the additive genetic variance regarding environmental variability under the model HE. This led to the conclusion that environmental variability of BrW in mice must be selected via dams. Estimated parameters in a reduced dataset without inbred animals did not substantially change this conclusion.</description><subject>Animal reproduction</subject><subject>Animals</subject><subject>Birth weight</subject><subject>Birth Weight - genetics</subject><subject>Birthweight</subject><subject>canalization</subject><subject>Environment</subject><subject>environmental variability</subject><subject>Female</subject><subject>genetic correlation</subject><subject>Genetics</subject><subject>Inbreeding</subject><subject>Male</subject><subject>Mice</subject><subject>Models, Genetic</subject><subject>Mothers</subject><subject>Rodents</subject><issn>0931-2668</issn><issn>1439-0388</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0U1PVDEUBuCGaGRAF_4BcxM3srjQ74-ljjBKiCREI7umtz0XOt6Psb0DzL-nOMDCxMRumjTPeZOeF6G3BB-Sco6WzdUhoZiSHTQjnJkaM61foBk2jNRUSr2L9nJeYlzelXmFdinHihOlZujzAgaYoq9WLrkeJki5asdUNTFN17cQr66nCoabmMahh2FyXXXjUnRN7OK0qeJQ9dHDa_SydV2GN4_3Pvpxcvx9_qU-O198nX88qz2nnNSeBWq8CLIVwWOlJdfAuHAGoAVmJC2saYLWgbLGaOlVYEHqgIXRjGvN9tGHbe4qjb_XkCfbx-yh69wA4zpbwpUSkmKG_4MKLTjhRhX6_i-6HNdpKB8piilaFihkUQdb5dOYc4LWrlLsXdpYgu1DC7a0YP-0UOy7x8R100N4lk9rL-BoC25jB5t_J9nTT4unyHo7EfMEd88TLv2yUjEl7M9vC6tOyVyxiwt7ye4B3wWeNw</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Pun, A.</creator><creator>Cervantes, I.</creator><creator>Nieto, B.</creator><creator>Salgado, C.</creator><creator>Pérez-Cabal, M.A.</creator><creator>Ibáñez-Escriche, N.</creator><creator>Gutiérrez, J.P.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201310</creationdate><title>Genetic parameters for birthweight environmental variability in mice</title><author>Pun, A. ; Cervantes, I. ; Nieto, B. ; Salgado, C. ; Pérez-Cabal, M.A. ; Ibáñez-Escriche, N. ; Gutiérrez, J.P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4241-c3d29c5d6f5dc078648e345a9eefe3962c42bbd88d23b986c7d3d68d059834883</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animal reproduction</topic><topic>Animals</topic><topic>Birth weight</topic><topic>Birth Weight - genetics</topic><topic>Birthweight</topic><topic>canalization</topic><topic>Environment</topic><topic>environmental variability</topic><topic>Female</topic><topic>genetic correlation</topic><topic>Genetics</topic><topic>Inbreeding</topic><topic>Male</topic><topic>Mice</topic><topic>Models, Genetic</topic><topic>Mothers</topic><topic>Rodents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pun, A.</creatorcontrib><creatorcontrib>Cervantes, I.</creatorcontrib><creatorcontrib>Nieto, B.</creatorcontrib><creatorcontrib>Salgado, C.</creatorcontrib><creatorcontrib>Pérez-Cabal, M.A.</creatorcontrib><creatorcontrib>Ibáñez-Escriche, N.</creatorcontrib><creatorcontrib>Gutiérrez, J.P.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of animal breeding and genetics (1986)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pun, A.</au><au>Cervantes, I.</au><au>Nieto, B.</au><au>Salgado, C.</au><au>Pérez-Cabal, M.A.</au><au>Ibáñez-Escriche, N.</au><au>Gutiérrez, J.P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic parameters for birthweight environmental variability in mice</atitle><jtitle>Journal of animal breeding and genetics (1986)</jtitle><addtitle>J. Anim. Breed. Genet</addtitle><date>2013-10</date><risdate>2013</risdate><volume>130</volume><issue>5</issue><spage>404</spage><epage>414</epage><pages>404-414</pages><issn>0931-2668</issn><eissn>1439-0388</eissn><abstract>Summary
Data from a divergent experiment for birthweight (BrW) environmental variability were used to estimate genetic parameters for BrW trait and its environmental variability by fitting both homoscedastic (HO) and heteroscedastic (HE) models. A total of 5 475 records of BrW from animals born from inbred dams, and 7 140 pedigree records were used. The heritability of BrW using the model HO was 0.27, with the litter effect much more important, 0.43. The model HE provided a genetic correlation between the trait and its environmental variability that was very high and negative, −0.97, and a high value for the additive genetic variance for environmental variability, suggesting an artefact in the model. The residual skewness was found to be essentially null. A model considering the genetic correlation null was also fitted, and used to obtain the breeding values for the selection process. Moreover, the trait was considered as maternal resulting in similar estimates under the model HO, but more reasonable for the genetic correlation between the trait and its environmental variability of 0.48 with a value of 0.25 for the additive genetic variance regarding environmental variability under the model HE. This led to the conclusion that environmental variability of BrW in mice must be selected via dams. Estimated parameters in a reduced dataset without inbred animals did not substantially change this conclusion.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>24074177</pmid><doi>10.1111/jbg.12021</doi><tpages>11</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animal reproduction Animals Birth weight Birth Weight - genetics Birthweight canalization Environment environmental variability Female genetic correlation Genetics Inbreeding Male Mice Models, Genetic Mothers Rodents |
| title | Genetic parameters for birthweight environmental variability in mice |
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