Acid Sphingomyelinase Regulates Platelet Cell Membrane Scrambling, Secretion, and Thrombus Formation

OBJECTIVE—Platelet activation is essential for primary hemostasis and acute thrombotic vascular occlusions. On activation, platelets release their prothrombotic granules and expose phosphatidylserine, thus fostering thrombin generation and thrombus formation. In other cell types, both degranulation...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2014-01, Vol.34 (1), p.61-71
Hauptverfasser:	Münzer, Patrick, Borst, Oliver, Walker, Britta, Schmid, Evi, Feijge, Marion A H, Cosemans, Judith M. E M, Chatterjee, Madhumita, Schmidt, Eva-Maria, Schmidt, Sebastian, Towhid, Syeda T, Leibrock, Christina, Elvers, Margitta, Schaller, Martin, Seizer, Peter, Ferlinz, Klaus, May, Andreas E, Gulbins, Erich, Heemskerk, Johan W M, Gawaz, Meinrad, Lang, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - blood Animals Blood Platelets - drug effects Blood Platelets - enzymology Calcium - blood Cell Degranulation - drug effects Cell Membrane - drug effects Cell Membrane - enzymology Ceramides - blood Chlorides Disease Models, Animal Enzyme Inhibitors - pharmacology Female Ferric Compounds Fibrinolytic Agents - pharmacology Male Mice Mice, Knockout P-Selectin - blood Phosphatidylserines - blood Platelet Activation - drug effects Platelet Aggregation Platelet Glycoprotein GPIIb-IIIa Complex - metabolism Sphingomyelin Phosphodiesterase - antagonists & inhibitors Sphingomyelin Phosphodiesterase - blood Sphingomyelin Phosphodiesterase - deficiency Sphingomyelin Phosphodiesterase - genetics Thrombin - metabolism Thrombosis - blood Thrombosis - chemically induced Thrombosis - enzymology Thrombosis - genetics Thrombosis - prevention & control Time Factors
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