A Novel Bullet Hits the Proteasome

A Novel Bullet Hits the Proteasome

An elegant paper by Anchoori and colleagues in this issue of Cancer Cell describes an irreversible inhibitor of Rpn13, one of the ubiquitin receptors on the 26S proteasome that is nonessential for proteasome function in most normal tissues, but is overexpressed in many solid tumors.

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Bibliographische Detailangaben
Veröffentlicht in:Cancer cell 2013-12, Vol.24 (6), p.691-693
1. Verfasser: Kisselev, Alexei F.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Female
Humans
Membrane Glycoproteins - antagonists & inhibitors
Neoplasms - drug therapy
Piperidones - pharmacology
Proteasome Inhibitors - pharmacology
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Beschreibung
Zusammenfassung:An elegant paper by Anchoori and colleagues in this issue of Cancer Cell describes an irreversible inhibitor of Rpn13, one of the ubiquitin receptors on the 26S proteasome that is nonessential for proteasome function in most normal tissues, but is overexpressed in many solid tumors.
ISSN:1535-6108
1878-3686
DOI:10.1016/j.ccr.2013.11.016