Increased susceptibility to streptozotocin and impeded regeneration capacity of beta-cells in adult offspring of malnourished rats

Background Epidemiological studies related poor maternal nutrition and subsequent growth retardation in the progeny to the development of diabetes later in life. Low‐protein diet during gestation altered the beta‐cell development of the rat progeny by decreasing beta‐cell proliferation and increasin...

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Veröffentlicht in:	Acta Physiologica 2014-01, Vol.210 (1), p.99-109
Hauptverfasser:	Goosse, K., Bouckenooghe, T., Sisino, G., Aurientis, S., Remacle, C., Reusens, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Animals beta-cell regeneration Cell Proliferation - drug effects Cells, Cultured diabetes Drug Resistance Female Fetal Nutrition Disorders - metabolism foetal programming Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Insulin-Secreting Cells - pathology low-protein diet Male Pregnancy Prenatal Exposure Delayed Effects - metabolism Protein Deficiency - metabolism Rats Rats, Wistar Regeneration - drug effects Streptozocin - pharmacology streptozotocin
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