Effects of organic modifier and temperature on the enantiomeric separation of several azole drugs using supercritical fluid chromatography and the Chiralpak AD column

ABSTRACT The effects of organic modifier and temperature on the enantioseparation of 10 triazoles and eight imidazoles, using supercritical fluid chromatography with the Chiralpak AD column, have been investigated in this work. For this purpose four different organic modifiers (methanol, ethanol, 2‐...

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Veröffentlicht in:	Biomedical chromatography 2014-01, Vol.28 (1), p.152-158
Hauptverfasser:	Toribio, L., Bernal, J. L., Martín, M. T., Bernal, J., del Nozal, M. J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amylose - analogs & derivatives Amylose - chemistry Azoles - chemistry Azoles - isolation & purification chiral separation Chiralpak AD Chromatography, Supercritical Fluid - instrumentation Chromatography, Supercritical Fluid - methods imidazoles and triazoles modifier effect Molecular Structure Pharmaceutical Preparations - chemistry Pharmaceutical Preparations - isolation & purification Phenylcarbamates - chemistry SFC Stereoisomerism Temperature temperature effect
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