Pathological tissue changes following intraoperative radiotherapy
Ninety patients with a variety of advanced-stage malignancies were treated with surgical resection, when feasible, and with intraoperative radiotherapy. Certain patients received additional external beam radiotherapy. During clinical follow-up, 45 patients died. Twenty-two patients (49% of deaths) u...
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| Veröffentlicht in: | American journal of clinical oncology 1986-12, Vol.9 (6), p.504-509 |
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| container_issue | 6 |
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| container_title | American journal of clinical oncology |
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| creator | SINDELAR, W. F HOEKSTRA, H RESTREPO, C KINSELLA, T. J |
| description | Ninety patients with a variety of advanced-stage malignancies were treated with surgical resection, when feasible, and with intraoperative radiotherapy. Certain patients received additional external beam radiotherapy. During clinical follow-up, 45 patients died. Twenty-two patients (49% of deaths) underwent detailed autopsies between 1 and 18 months after treatment, with special attention directed towards assessing radiation damage to various tissues. Histological changes related to radiation were generally manifested as fibrosis. Mild fibrotic changes in retroperitoneal soft tissues and mild hypocellularity in vertebral bone marrow were consistently present in patients treated for pancreatic carcinoma, gastric carcinoma, and retroperitoneal or pelvic sarcomas. Fibrosis of the soft tissues of the porta hepatis without narrowing of the bile duct was present in patients treated for pancreatic or gastric cancer. perineural fibrosis was present in retroperitoneal and pelvic nerve trunks in patients treated for abdominal or pelvic sarcomas and in patients treated for unresectable carcinoma of the pancreas. Significant radiation-related changes were generally not observed in major blood vessels, intestine, or ureter. Intact irradiated primary tumors consistently displayed necrosis. |
| doi_str_mv | 10.1097/00000421-198612000-00008 |
| format | Article |
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Fibrosis of the soft tissues of the porta hepatis without narrowing of the bile duct was present in patients treated for pancreatic or gastric cancer. perineural fibrosis was present in retroperitoneal and pelvic nerve trunks in patients treated for abdominal or pelvic sarcomas and in patients treated for unresectable carcinoma of the pancreas. Significant radiation-related changes were generally not observed in major blood vessels, intestine, or ureter. Intact irradiated primary tumors consistently displayed necrosis.</description><identifier>ISSN: 0277-3732</identifier><identifier>EISSN: 1537-453X</identifier><identifier>DOI: 10.1097/00000421-198612000-00008</identifier><identifier>PMID: 3788852</identifier><identifier>CODEN: AJCODI</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Autopsy ; Biological and medical sciences ; Blood Vessels - pathology ; Combined Modality Therapy ; Combined treatment ; Follow-Up Studies ; Humans ; Intestines - pathology ; Intraoperative Period ; Liver - pathology ; Medical sciences ; Neoplasms - mortality ; Neoplasms - pathology ; Neoplasms - surgery ; Pancreas - pathology ; Pancreatic Neoplasms - radiotherapy ; Peripheral Nerves - pathology ; Radiotherapy - adverse effects ; Radiotherapy Dosage ; Retroperitoneal Space - pathology ; Treatment. 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F</creatorcontrib><creatorcontrib>HOEKSTRA, H</creatorcontrib><creatorcontrib>RESTREPO, C</creatorcontrib><creatorcontrib>KINSELLA, T. J</creatorcontrib><title>Pathological tissue changes following intraoperative radiotherapy</title><title>American journal of clinical oncology</title><addtitle>Am J Clin Oncol</addtitle><description>Ninety patients with a variety of advanced-stage malignancies were treated with surgical resection, when feasible, and with intraoperative radiotherapy. Certain patients received additional external beam radiotherapy. During clinical follow-up, 45 patients died. Twenty-two patients (49% of deaths) underwent detailed autopsies between 1 and 18 months after treatment, with special attention directed towards assessing radiation damage to various tissues. Histological changes related to radiation were generally manifested as fibrosis. Mild fibrotic changes in retroperitoneal soft tissues and mild hypocellularity in vertebral bone marrow were consistently present in patients treated for pancreatic carcinoma, gastric carcinoma, and retroperitoneal or pelvic sarcomas. Fibrosis of the soft tissues of the porta hepatis without narrowing of the bile duct was present in patients treated for pancreatic or gastric cancer. perineural fibrosis was present in retroperitoneal and pelvic nerve trunks in patients treated for abdominal or pelvic sarcomas and in patients treated for unresectable carcinoma of the pancreas. Significant radiation-related changes were generally not observed in major blood vessels, intestine, or ureter. Intact irradiated primary tumors consistently displayed necrosis.</description><subject>Autopsy</subject><subject>Biological and medical sciences</subject><subject>Blood Vessels - pathology</subject><subject>Combined Modality Therapy</subject><subject>Combined treatment</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Intestines - pathology</subject><subject>Intraoperative Period</subject><subject>Liver - pathology</subject><subject>Medical sciences</subject><subject>Neoplasms - mortality</subject><subject>Neoplasms - pathology</subject><subject>Neoplasms - surgery</subject><subject>Pancreas - pathology</subject><subject>Pancreatic Neoplasms - radiotherapy</subject><subject>Peripheral Nerves - pathology</subject><subject>Radiotherapy - adverse effects</subject><subject>Radiotherapy Dosage</subject><subject>Retroperitoneal Space - pathology</subject><subject>Treatment. 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J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-7f05538de7572cd071e631025c8c0249915f2c786c9d03ccd7bc13fdee9591323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Autopsy</topic><topic>Biological and medical sciences</topic><topic>Blood Vessels - pathology</topic><topic>Combined Modality Therapy</topic><topic>Combined treatment</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Intestines - pathology</topic><topic>Intraoperative Period</topic><topic>Liver - pathology</topic><topic>Medical sciences</topic><topic>Neoplasms - mortality</topic><topic>Neoplasms - pathology</topic><topic>Neoplasms - surgery</topic><topic>Pancreas - pathology</topic><topic>Pancreatic Neoplasms - radiotherapy</topic><topic>Peripheral Nerves - pathology</topic><topic>Radiotherapy - adverse effects</topic><topic>Radiotherapy Dosage</topic><topic>Retroperitoneal Space - pathology</topic><topic>Treatment. 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| fulltext | fulltext |
| identifier | ISSN: 0277-3732 |
| ispartof | American journal of clinical oncology, 1986-12, Vol.9 (6), p.504-509 |
| issn | 0277-3732 1537-453X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Autopsy Biological and medical sciences Blood Vessels - pathology Combined Modality Therapy Combined treatment Follow-Up Studies Humans Intestines - pathology Intraoperative Period Liver - pathology Medical sciences Neoplasms - mortality Neoplasms - pathology Neoplasms - surgery Pancreas - pathology Pancreatic Neoplasms - radiotherapy Peripheral Nerves - pathology Radiotherapy - adverse effects Radiotherapy Dosage Retroperitoneal Space - pathology Treatment. General aspects Tumors |
| title | Pathological tissue changes following intraoperative radiotherapy |
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