Detoxification enzymes following intrastriatal kainic acid
A complete explanation of the neurotoxicity that follows kainic acid (KA) injection into the rat striatum is lacking. An assessment of the chronological course after intrastriatal KA injection of the activities of enzymes preferentially concentrated in glia or involved in the detoxification of oxyge...
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| Veröffentlicht in: | Neurochemical research 1987-05, Vol.12 (5), p.425-429 |
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| container_title | Neurochemical research |
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| creator | COHEN, M. R RAMCHAND, C. N SAILER, V FERNANDEZ, M MCAMIS, W SRIDHARA, N ALSTON, C |
| description | A complete explanation of the neurotoxicity that follows kainic acid (KA) injection into the rat striatum is lacking. An assessment of the chronological course after intrastriatal KA injection of the activities of enzymes preferentially concentrated in glia or involved in the detoxification of oxygen metabolites is accomplished. An enhancement of the specific activities of glutathione peroxidase (GP) and catalase is found without an alteration in the specific activity of superoxide dismutase (SOD). There is no increase in the in vivo striatal levels of malondialdehyde, a putative indicator of lipid peroxidation, the expected result of cell membrane damage from oxygen metabolites. Understanding the mechanism and importance of the preferential induction of the activities of the detoxification enzymes will require further study. |
| doi_str_mv | 10.1007/bf00972293 |
| format | Article |
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Understanding the mechanism and importance of the preferential induction of the activities of the detoxification enzymes will require further study.</description><identifier>ISSN: 0364-3190</identifier><identifier>EISSN: 1573-6903</identifier><identifier>DOI: 10.1007/bf00972293</identifier><identifier>PMID: 2884584</identifier><identifier>CODEN: NEREDZ</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Animals ; Biological and medical sciences ; Catalase - metabolism ; Corpus Striatum - analysis ; Corpus Striatum - drug effects ; Corpus Striatum - enzymology ; Glutamate-Ammonia Ligase - metabolism ; Glutathione Peroxidase - metabolism ; Kainic Acid - pharmacology ; Male ; Malondialdehyde - analysis ; Medical sciences ; Nervous system involvement in other diseases. 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There is no increase in the in vivo striatal levels of malondialdehyde, a putative indicator of lipid peroxidation, the expected result of cell membrane damage from oxygen metabolites. Understanding the mechanism and importance of the preferential induction of the activities of the detoxification enzymes will require further study.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Catalase - metabolism</subject><subject>Corpus Striatum - analysis</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - enzymology</subject><subject>Glutamate-Ammonia Ligase - metabolism</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Kainic Acid - pharmacology</subject><subject>Male</subject><subject>Malondialdehyde - analysis</subject><subject>Medical sciences</subject><subject>Nervous system involvement in other diseases. 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N ; SAILER, V ; FERNANDEZ, M ; MCAMIS, W ; SRIDHARA, N ; ALSTON, C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-270fc49b7aba7f96cbefca0ba0df13d92f1493ff7b538bbbbcf40e929361bf9f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Catalase - metabolism</topic><topic>Corpus Striatum - analysis</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - enzymology</topic><topic>Glutamate-Ammonia Ligase - metabolism</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Kainic Acid - pharmacology</topic><topic>Male</topic><topic>Malondialdehyde - analysis</topic><topic>Medical sciences</topic><topic>Nervous system involvement in other diseases. Miscellaneous</topic><topic>Neurology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Superoxide Dismutase - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>COHEN, M. R</creatorcontrib><creatorcontrib>RAMCHAND, C. N</creatorcontrib><creatorcontrib>SAILER, V</creatorcontrib><creatorcontrib>FERNANDEZ, M</creatorcontrib><creatorcontrib>MCAMIS, W</creatorcontrib><creatorcontrib>SRIDHARA, N</creatorcontrib><creatorcontrib>ALSTON, C</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><jtitle>Neurochemical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>COHEN, M. R</au><au>RAMCHAND, C. N</au><au>SAILER, V</au><au>FERNANDEZ, M</au><au>MCAMIS, W</au><au>SRIDHARA, N</au><au>ALSTON, C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Detoxification enzymes following intrastriatal kainic acid</atitle><jtitle>Neurochemical research</jtitle><addtitle>Neurochem Res</addtitle><date>1987-05-01</date><risdate>1987</risdate><volume>12</volume><issue>5</issue><spage>425</spage><epage>429</epage><pages>425-429</pages><issn>0364-3190</issn><eissn>1573-6903</eissn><coden>NEREDZ</coden><abstract>A complete explanation of the neurotoxicity that follows kainic acid (KA) injection into the rat striatum is lacking. An assessment of the chronological course after intrastriatal KA injection of the activities of enzymes preferentially concentrated in glia or involved in the detoxification of oxygen metabolites is accomplished. An enhancement of the specific activities of glutathione peroxidase (GP) and catalase is found without an alteration in the specific activity of superoxide dismutase (SOD). There is no increase in the in vivo striatal levels of malondialdehyde, a putative indicator of lipid peroxidation, the expected result of cell membrane damage from oxygen metabolites. Understanding the mechanism and importance of the preferential induction of the activities of the detoxification enzymes will require further study.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>2884584</pmid><doi>10.1007/bf00972293</doi><tpages>5</tpages></addata></record> |
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| ispartof | Neurochemical research, 1987-05, Vol.12 (5), p.425-429 |
| issn | 0364-3190 1573-6903 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Biological and medical sciences Catalase - metabolism Corpus Striatum - analysis Corpus Striatum - drug effects Corpus Striatum - enzymology Glutamate-Ammonia Ligase - metabolism Glutathione Peroxidase - metabolism Kainic Acid - pharmacology Male Malondialdehyde - analysis Medical sciences Nervous system involvement in other diseases. Miscellaneous Neurology Rats Rats, Inbred Strains Superoxide Dismutase - metabolism |
| title | Detoxification enzymes following intrastriatal kainic acid |
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