In Vitro and in Vivo Studies of Streptomycin-Resistant, Penicillin-Susceptible Streptococci from Patients with Infective Endocarditis
The combination of penicillin and streptomycin did not act synergistically in vitro against three streptomycin-resistant strains (MIC, ⩾1,OOO μg of streptomycin/ml) of penicillin-susceptible streptococci. Using a model of experimental infective endocarditis, weinfected rabbits with a control strepto...
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| Veröffentlicht in: | The Journal of infectious diseases 1987-05, Vol.155 (5), p.954-958 |
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| container_title | The Journal of infectious diseases |
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| creator | Enzler, Mark J. Rouse, Mark S. Henry, Nancy K. Geraci, Joseph E. Wilson, Walter R. |
| description | The combination of penicillin and streptomycin did not act synergistically in vitro against three streptomycin-resistant strains (MIC, ⩾1,OOO μg of streptomycin/ml) of penicillin-susceptible streptococci. Using a model of experimental infective endocarditis, weinfected rabbits with a control streptomycin-susceptible strain, with an intermediately streptomycinresistant strain (MIC, 1,000 μg/ml), and with a highly streptomycin-resistant strain (MIC, >32,000 μg/ml), Treating animals with a combination of procaine penicillin and streptomycin was more effective (P < .01) than treating them with procaine penicillin alone only for those animals infected with the control streptomycin-susceptible strain. Treatment with procaine penicillin plus gentamicin was more effective (P < .01)than treatment with procaine penicillin alone for all three treatment groups and was more effective (P < .01)than treatment with procaine penicillin and streptomycin for those animals infected with an intermediately or highly streptomycin-resistant strain of streptococci. |
| doi_str_mv | 10.1093/infdis/155.5.954 |
| format | Article |
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Using a model of experimental infective endocarditis, weinfected rabbits with a control streptomycin-susceptible strain, with an intermediately streptomycinresistant strain (MIC, 1,000 μg/ml), and with a highly streptomycin-resistant strain (MIC, >32,000 μg/ml), Treating animals with a combination of procaine penicillin and streptomycin was more effective (P < .01) than treating them with procaine penicillin alone only for those animals infected with the control streptomycin-susceptible strain. Treatment with procaine penicillin plus gentamicin was more effective (P < .01)than treatment with procaine penicillin alone for all three treatment groups and was more effective (P < .01)than treatment with procaine penicillin and streptomycin for those animals infected with an intermediately or highly streptomycin-resistant strain of streptococci.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/155.5.954</identifier><identifier>PMID: 3644854</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Aminoglycosides ; Animals ; Antibacterial agents ; Antibiotics ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antimicrobials ; Biological and medical sciences ; Chemotherapy ; Drug Synergism ; Drug Therapy, Combination ; Endocarditis ; Endocarditis, Bacterial - drug therapy ; Endocarditis, Bacterial - microbiology ; Gentamicins - pharmacology ; Gentamicins - therapeutic use ; Heart catheterization ; Heart valves ; Humans ; Medical sciences ; Original Articles ; Penicillin ; Penicillin G - pharmacology ; Penicillin G Procaine - pharmacology ; Penicillin G Procaine - therapeutic use ; Penicillin Resistance ; Pharmacology. Drug treatments ; Rabbits ; Streptococcal Infections - drug therapy ; Streptococcal Infections - microbiology ; Streptococcus - drug effects ; Streptomycin - pharmacology ; Streptomycin - therapeutic use ; Vegetation ; Viridans Streptococci</subject><ispartof>The Journal of infectious diseases, 1987-05, Vol.155 (5), p.954-958</ispartof><rights>Copyright 1987 The University of Chicago</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c329t-de32e69b4cfd8c2258f65a560fd1f8ff268e699affcac90992bdba473ad552423</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30106227$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30106227$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27923,27924,58016,58249</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7568447$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3644854$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Enzler, Mark J.</creatorcontrib><creatorcontrib>Rouse, Mark S.</creatorcontrib><creatorcontrib>Henry, Nancy K.</creatorcontrib><creatorcontrib>Geraci, Joseph E.</creatorcontrib><creatorcontrib>Wilson, Walter R.</creatorcontrib><title>In Vitro and in Vivo Studies of Streptomycin-Resistant, Penicillin-Susceptible Streptococci from Patients with Infective Endocarditis</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>The combination of penicillin and streptomycin did not act synergistically in vitro against three streptomycin-resistant strains (MIC, ⩾1,OOO μg of streptomycin/ml) of penicillin-susceptible streptococci. Using a model of experimental infective endocarditis, weinfected rabbits with a control streptomycin-susceptible strain, with an intermediately streptomycinresistant strain (MIC, 1,000 μg/ml), and with a highly streptomycin-resistant strain (MIC, >32,000 μg/ml), Treating animals with a combination of procaine penicillin and streptomycin was more effective (P < .01) than treating them with procaine penicillin alone only for those animals infected with the control streptomycin-susceptible strain. Treatment with procaine penicillin plus gentamicin was more effective (P < .01)than treatment with procaine penicillin alone for all three treatment groups and was more effective (P < .01)than treatment with procaine penicillin and streptomycin for those animals infected with an intermediately or highly streptomycin-resistant strain of streptococci.</description><subject>Aminoglycosides</subject><subject>Animals</subject><subject>Antibacterial agents</subject><subject>Antibiotics</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antimicrobials</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Drug Synergism</subject><subject>Drug Therapy, Combination</subject><subject>Endocarditis</subject><subject>Endocarditis, Bacterial - drug therapy</subject><subject>Endocarditis, Bacterial - microbiology</subject><subject>Gentamicins - pharmacology</subject><subject>Gentamicins - therapeutic use</subject><subject>Heart catheterization</subject><subject>Heart valves</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Original Articles</subject><subject>Penicillin</subject><subject>Penicillin G - pharmacology</subject><subject>Penicillin G Procaine - pharmacology</subject><subject>Penicillin G Procaine - therapeutic use</subject><subject>Penicillin Resistance</subject><subject>Pharmacology. Drug treatments</subject><subject>Rabbits</subject><subject>Streptococcal Infections - drug therapy</subject><subject>Streptococcal Infections - microbiology</subject><subject>Streptococcus - drug effects</subject><subject>Streptomycin - pharmacology</subject><subject>Streptomycin - therapeutic use</subject><subject>Vegetation</subject><subject>Viridans Streptococci</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkUtvEzEUhUcIVEJhzwbJC8SKSf2e8RJFhQZFomp5VGwsjx_CZcYOtqfQH8D_xlHSsPL1_c49ujq3aV4iuERQkDMfnPH5DDG2ZEvB6KNmgRjpWs4RedwsIMS4Rb0QT5tnOd9CCCnh3UlzQjilPaOL5u86gK--pAhUMMDvPncRXJfZeJtBdLVMdlvidK99aK9s9rmoUN6CSxu89uNYu9dz1lXjh9E-yHXU2gOX4gQuVfE2lAx--_IDrIOzuvg7C86DiVol44vPz5snTo3Zvji8p82X9-efVxft5tOH9erdptUEi9IaS7DlYqDamV5jzHrHmWIcOoNc7xzmfcVCOaeVFlAIPJhB0Y4owximmJw2b_a-2xR_zTYXOfm6-ziqYOOcJaIdExT2VQj3Qp1izsk6uU1-UuleIih3yct98rImL5msydeRVwfveZisOQ4coq789YGrrNXokgq6GjzIOsZ7Wlc92tzmEtN_F4ggx3jH2z2vh7B_jlyln5J3pGPy4ua77G42H7-tGJRX5B-0Hqlr</recordid><startdate>198705</startdate><enddate>198705</enddate><creator>Enzler, Mark J.</creator><creator>Rouse, Mark S.</creator><creator>Henry, Nancy K.</creator><creator>Geraci, Joseph E.</creator><creator>Wilson, Walter R.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>198705</creationdate><title>In Vitro and in Vivo Studies of Streptomycin-Resistant, Penicillin-Susceptible Streptococci from Patients with Infective Endocarditis</title><author>Enzler, Mark J. ; Rouse, Mark S. ; Henry, Nancy K. ; Geraci, Joseph E. ; Wilson, Walter R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c329t-de32e69b4cfd8c2258f65a560fd1f8ff268e699affcac90992bdba473ad552423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Aminoglycosides</topic><topic>Animals</topic><topic>Antibacterial agents</topic><topic>Antibiotics</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antimicrobials</topic><topic>Biological and medical sciences</topic><topic>Chemotherapy</topic><topic>Drug Synergism</topic><topic>Drug Therapy, Combination</topic><topic>Endocarditis</topic><topic>Endocarditis, Bacterial - drug therapy</topic><topic>Endocarditis, Bacterial - microbiology</topic><topic>Gentamicins - pharmacology</topic><topic>Gentamicins - therapeutic use</topic><topic>Heart catheterization</topic><topic>Heart valves</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Original Articles</topic><topic>Penicillin</topic><topic>Penicillin G - pharmacology</topic><topic>Penicillin G Procaine - pharmacology</topic><topic>Penicillin G Procaine - therapeutic use</topic><topic>Penicillin Resistance</topic><topic>Pharmacology. Drug treatments</topic><topic>Rabbits</topic><topic>Streptococcal Infections - drug therapy</topic><topic>Streptococcal Infections - microbiology</topic><topic>Streptococcus - drug effects</topic><topic>Streptomycin - pharmacology</topic><topic>Streptomycin - therapeutic use</topic><topic>Vegetation</topic><topic>Viridans Streptococci</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Enzler, Mark J.</creatorcontrib><creatorcontrib>Rouse, Mark S.</creatorcontrib><creatorcontrib>Henry, Nancy K.</creatorcontrib><creatorcontrib>Geraci, Joseph E.</creatorcontrib><creatorcontrib>Wilson, Walter R.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Enzler, Mark J.</au><au>Rouse, Mark S.</au><au>Henry, Nancy K.</au><au>Geraci, Joseph E.</au><au>Wilson, Walter R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vitro and in Vivo Studies of Streptomycin-Resistant, Penicillin-Susceptible Streptococci from Patients with Infective Endocarditis</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1987-05</date><risdate>1987</risdate><volume>155</volume><issue>5</issue><spage>954</spage><epage>958</epage><pages>954-958</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>The combination of penicillin and streptomycin did not act synergistically in vitro against three streptomycin-resistant strains (MIC, ⩾1,OOO μg of streptomycin/ml) of penicillin-susceptible streptococci. Using a model of experimental infective endocarditis, weinfected rabbits with a control streptomycin-susceptible strain, with an intermediately streptomycinresistant strain (MIC, 1,000 μg/ml), and with a highly streptomycin-resistant strain (MIC, >32,000 μg/ml), Treating animals with a combination of procaine penicillin and streptomycin was more effective (P < .01) than treating them with procaine penicillin alone only for those animals infected with the control streptomycin-susceptible strain. Treatment with procaine penicillin plus gentamicin was more effective (P < .01)than treatment with procaine penicillin alone for all three treatment groups and was more effective (P < .01)than treatment with procaine penicillin and streptomycin for those animals infected with an intermediately or highly streptomycin-resistant strain of streptococci.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>3644854</pmid><doi>10.1093/infdis/155.5.954</doi><tpages>5</tpages></addata></record> |
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| subjects | Aminoglycosides Animals Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobials Biological and medical sciences Chemotherapy Drug Synergism Drug Therapy, Combination Endocarditis Endocarditis, Bacterial - drug therapy Endocarditis, Bacterial - microbiology Gentamicins - pharmacology Gentamicins - therapeutic use Heart catheterization Heart valves Humans Medical sciences Original Articles Penicillin Penicillin G - pharmacology Penicillin G Procaine - pharmacology Penicillin G Procaine - therapeutic use Penicillin Resistance Pharmacology. Drug treatments Rabbits Streptococcal Infections - drug therapy Streptococcal Infections - microbiology Streptococcus - drug effects Streptomycin - pharmacology Streptomycin - therapeutic use Vegetation Viridans Streptococci |
| title | In Vitro and in Vivo Studies of Streptomycin-Resistant, Penicillin-Susceptible Streptococci from Patients with Infective Endocarditis |
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