Decrease in oligodendrocyte carbonic anhydrase activity preceding myelin degeneration in cuprizone induced demyelination

Both immunohistochemical and biochemical evidence is presented to show for the first time that carbonic anhydrase II (CA II) activity falls in the brain of mice in cuprizone (bis(cyclohexanone)oxalyldihydrazone) induced demyelination well before demyelination develops. This fall began during the fir...

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Veröffentlicht in:	Journal of the neurological sciences 1987-06, Vol.79 (1), p.141-148
Hauptverfasser:	Komoly, Samuel, Jeyasingham, Marina D., Pratt, Oliver E., Lantos, Peter L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Brain Brain - enzymology Brain - pathology Carbonic anhydrase Carbonic Anhydrases - metabolism Cuprizone Demyelinating Diseases - chemically induced Demyelinating Diseases - enzymology Demyelinating Diseases - metabolism Demyelinating Diseases - pathology Demyelination Glial Fibrillary Acidic Protein - metabolism Male Medical sciences Mice Myelin Myelin Basic Protein - metabolism Myelin Sheath - pathology Nerve Degeneration Nervous system involvement in other diseases. Miscellaneous Neuroglia - enzymology Neurology Oligodendrocyte Oligodendroglia - enzymology Oligodendroglia - metabolism Oligodendroglia - pathology Time Factors
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