Cardiomyopathy in Soman and Sarin intoxicated rats
Rats surviving various single doses of the Organophosphorus anticholinesterase nerve agents Soman and Sarin were examined by light microscopy at intervals up to 35 days post-exposure. Brain lesions, identical to those that have been reported elsewhere were present, as well as a previously unreported...
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| Veröffentlicht in: | Toxicology letters 1987-05, Vol.36 (3), p.243-249 |
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| container_end_page | 249 |
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| container_title | Toxicology letters |
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| creator | Singer, A.W. Jaax, N.K. Graham, J.S. McLeod, C.G. |
| description | Rats surviving various single doses of the Organophosphorus anticholinesterase nerve agents Soman and Sarin were examined by light microscopy at intervals up to 35 days post-exposure. Brain lesions, identical to those that have been reported elsewhere were present, as well as a previously unreported finding associated with Soman or Sarin intoxication: half of all animals that had brain lesions also had areas of myocardial degeneration and necrosis. Depending upon the point in time at which cardiac tissues were examined, findings varied from areas of acute myolysis and necrosis to areas undergoing resolution of damage. The finding of brain lesions in those animals having cardiac lesions suggests a relationship between the convulsion induced neurologic and cardiac lesions. These studies suggest that convulsive doses of chemical warfare agents induce pathological changes in the cardiovascular system of laboratory animals. |
| doi_str_mv | 10.1016/0378-4274(87)90192-5 |
| format | Article |
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Brain lesions, identical to those that have been reported elsewhere were present, as well as a previously unreported finding associated with Soman or Sarin intoxication: half of all animals that had brain lesions also had areas of myocardial degeneration and necrosis. Depending upon the point in time at which cardiac tissues were examined, findings varied from areas of acute myolysis and necrosis to areas undergoing resolution of damage. The finding of brain lesions in those animals having cardiac lesions suggests a relationship between the convulsion induced neurologic and cardiac lesions. These studies suggest that convulsive doses of chemical warfare agents induce pathological changes in the cardiovascular system of laboratory animals.</description><identifier>ISSN: 0378-4274</identifier><identifier>EISSN: 1879-3169</identifier><identifier>DOI: 10.1016/0378-4274(87)90192-5</identifier><identifier>PMID: 3590220</identifier><identifier>CODEN: TOLED5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Animals ; Biological and medical sciences ; Brain - drug effects ; Brain - pathology ; cardiac lesions ; cardiomyopathy ; Chemical and industrial products toxicology. Toxic occupational diseases ; Heart - drug effects ; Male ; Medical sciences ; Myocardium - pathology ; Necrosis ; neural lesions ; Organophosphorus ; organophosphorus compounds ; Organophosphorus Compounds - toxicity ; Rats ; Rats, Inbred Strains ; Sarin - toxicity ; Seizures - chemically induced ; Soman - toxicity ; toxicity ; Toxicology ; Various organic compounds</subject><ispartof>Toxicology letters, 1987-05, Vol.36 (3), p.243-249</ispartof><rights>1987</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-f52042d857b6691b99f9473367e8b82adf09e9c564b67e5fcedaf1c396b70f1f3</citedby><cites>FETCH-LOGICAL-c441t-f52042d857b6691b99f9473367e8b82adf09e9c564b67e5fcedaf1c396b70f1f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-4274(87)90192-5$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7458056$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3590220$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Singer, A.W.</creatorcontrib><creatorcontrib>Jaax, N.K.</creatorcontrib><creatorcontrib>Graham, J.S.</creatorcontrib><creatorcontrib>McLeod, C.G.</creatorcontrib><title>Cardiomyopathy in Soman and Sarin intoxicated rats</title><title>Toxicology letters</title><addtitle>Toxicol Lett</addtitle><description>Rats surviving various single doses of the Organophosphorus anticholinesterase nerve agents Soman and Sarin were examined by light microscopy at intervals up to 35 days post-exposure. Brain lesions, identical to those that have been reported elsewhere were present, as well as a previously unreported finding associated with Soman or Sarin intoxication: half of all animals that had brain lesions also had areas of myocardial degeneration and necrosis. Depending upon the point in time at which cardiac tissues were examined, findings varied from areas of acute myolysis and necrosis to areas undergoing resolution of damage. The finding of brain lesions in those animals having cardiac lesions suggests a relationship between the convulsion induced neurologic and cardiac lesions. These studies suggest that convulsive doses of chemical warfare agents induce pathological changes in the cardiovascular system of laboratory animals.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - pathology</subject><subject>cardiac lesions</subject><subject>cardiomyopathy</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Heart - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myocardium - pathology</subject><subject>Necrosis</subject><subject>neural lesions</subject><subject>Organophosphorus</subject><subject>organophosphorus compounds</subject><subject>Organophosphorus Compounds - toxicity</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Sarin - toxicity</subject><subject>Seizures - chemically induced</subject><subject>Soman - toxicity</subject><subject>toxicity</subject><subject>Toxicology</subject><subject>Various organic compounds</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEQgIMoWh__QHEPInpYTbJ5bC6CFF8geKiew2w20Uh3U5Ot2H9vakuPnoaZ-WaY-RA6JviKYCKucSXrklHJLmp5qTBRtORbaERqqcqKCLWNRhtkD-2n9IkxFkzwXbRbcYUpxSNExxBbH7pFmMHwsSh8X0xCB30BfVtMIObc90P48QYG2xYRhnSIdhxMkz1axwP0dn_3On4sn18ensa3z6VhjAyl4xQz2tZcNkIo0ijlFJNVJaStm5pC67CyynDBmlziztgWHDGVEo3EjrjqAJ2v9s5i-JrbNOjOJ2OnU-htmCdNmGRScJlBtgJNDClF6_Qs-g7iQhOsl6r00oNeetC11H-qNM9jJ-v986az7WZo7Sb3z9Z9SAamLkJvfNpgkvEac5Gx0xXmIGh4jxl5m1BMKkwYVYSpTNysCJttfXsbdTLe9vlhH60ZdBv8_5f-AuyOjMA</recordid><startdate>19870501</startdate><enddate>19870501</enddate><creator>Singer, A.W.</creator><creator>Jaax, N.K.</creator><creator>Graham, J.S.</creator><creator>McLeod, C.G.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>19870501</creationdate><title>Cardiomyopathy in Soman and Sarin intoxicated rats</title><author>Singer, A.W. ; Jaax, N.K. ; Graham, J.S. ; McLeod, C.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-f52042d857b6691b99f9473367e8b82adf09e9c564b67e5fcedaf1c396b70f1f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - pathology</topic><topic>cardiac lesions</topic><topic>cardiomyopathy</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Heart - drug effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Myocardium - pathology</topic><topic>Necrosis</topic><topic>neural lesions</topic><topic>Organophosphorus</topic><topic>organophosphorus compounds</topic><topic>Organophosphorus Compounds - toxicity</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Sarin - toxicity</topic><topic>Seizures - chemically induced</topic><topic>Soman - toxicity</topic><topic>toxicity</topic><topic>Toxicology</topic><topic>Various organic compounds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Singer, A.W.</creatorcontrib><creatorcontrib>Jaax, N.K.</creatorcontrib><creatorcontrib>Graham, J.S.</creatorcontrib><creatorcontrib>McLeod, C.G.</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Singer, A.W.</au><au>Jaax, N.K.</au><au>Graham, J.S.</au><au>McLeod, C.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiomyopathy in Soman and Sarin intoxicated rats</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>1987-05-01</date><risdate>1987</risdate><volume>36</volume><issue>3</issue><spage>243</spage><epage>249</epage><pages>243-249</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><coden>TOLED5</coden><abstract>Rats surviving various single doses of the Organophosphorus anticholinesterase nerve agents Soman and Sarin were examined by light microscopy at intervals up to 35 days post-exposure. Brain lesions, identical to those that have been reported elsewhere were present, as well as a previously unreported finding associated with Soman or Sarin intoxication: half of all animals that had brain lesions also had areas of myocardial degeneration and necrosis. Depending upon the point in time at which cardiac tissues were examined, findings varied from areas of acute myolysis and necrosis to areas undergoing resolution of damage. The finding of brain lesions in those animals having cardiac lesions suggests a relationship between the convulsion induced neurologic and cardiac lesions. These studies suggest that convulsive doses of chemical warfare agents induce pathological changes in the cardiovascular system of laboratory animals.</abstract><cop>Shannon</cop><cop>Amsterdam</cop><pub>Elsevier Ireland Ltd</pub><pmid>3590220</pmid><doi>10.1016/0378-4274(87)90192-5</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0378-4274 |
| ispartof | Toxicology letters, 1987-05, Vol.36 (3), p.243-249 |
| issn | 0378-4274 1879-3169 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Animals Biological and medical sciences Brain - drug effects Brain - pathology cardiac lesions cardiomyopathy Chemical and industrial products toxicology. Toxic occupational diseases Heart - drug effects Male Medical sciences Myocardium - pathology Necrosis neural lesions Organophosphorus organophosphorus compounds Organophosphorus Compounds - toxicity Rats Rats, Inbred Strains Sarin - toxicity Seizures - chemically induced Soman - toxicity toxicity Toxicology Various organic compounds |
| title | Cardiomyopathy in Soman and Sarin intoxicated rats |
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