Nucleotide sequence and deduced amino acid sequence of Escherichia coli adenine phosphoribosyl-transferase and comparison with other analogous enzymes

Nucleotide sequence and deduced amino acid sequence of Escherichia coli adenine phosphoribosyl-transferase and comparison with other analogous enzymes

The Escherichia coli apt gene has been analyzed and its nucleotide (nt) sequence and the deduced amino acid (aa) sequence compared to those of other phosphoribosyltransferases (PRTs). The apt mRNA has a 102-nt leader sequence which may form alternate secondary structures. The RNA transcript may also...

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Veröffentlicht in:Gene 1986, Vol.43 (3), p.287-293
Hauptverfasser: Hershey, Howard V., Taylor, Milton W.
Format: Artikel
Sprache:eng
Schlagworte:
Biological and medical sciences
conserved sequences
Escherichia coli
Fundamental and applied biological sciences. Psychology
Genes. Genome
homologies among phosphoribosyltransferases
Molecular and cellular biology
Molecular genetics
purine salvage enzymes
Recombinant DNA
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Zusammenfassung:The Escherichia coli apt gene has been analyzed and its nucleotide (nt) sequence and the deduced amino acid (aa) sequence compared to those of other phosphoribosyltransferases (PRTs). The apt mRNA has a 102-nt leader sequence which may form alternate secondary structures. The RNA transcript may also form several 3' hairpin structures, which, however, do not appear to act as Rho-independent terminators. All PRTs, including E. coli adenine PRT (APRT), have a strongly conserved 13-aa sequence, as well as other regions of aa sequence or structural similarity. E. coli APRT is remarkably similar to the mouse enzyme.
ISSN:0378-1119
1879-0038
DOI:10.1016/0378-1119(86)90218-0