Neurosteroids: Cytochrome P-450 sub(scc) in rat brain

Immunohistochemical studies have been performed with specific antibodies to bovine adrenal cytochrome P-450 sub(scc), which is involved in cholesterol side-chain cleavage and pregnenolone formation. The enzyme was localized in the white matter throughout the brain. Scarce clusters of cell bodies wer...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1987-01, Vol.237 (4819), p.1212-1214
Hauptverfasser:	Le Goascogne, C, Robel, P, Gouezou, M, Sananes, N, Baulieu, E-E, Waterman, M
Format:	Artikel
Sprache:	eng
Schlagworte:	brain cytochrome P450scc
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creator	Le Goascogne, C Robel, P Gouezou, M Sananes, N Baulieu, E-E Waterman, M
description	Immunohistochemical studies have been performed with specific antibodies to bovine adrenal cytochrome P-450 sub(scc), which is involved in cholesterol side-chain cleavage and pregnenolone formation. The enzyme was localized in the white matter throughout the brain. Scarce clusters of cell bodies were also stained in the entorhinal and cingulate cortex and in the olfactory bulb. These observations strongly support the existence of "neurosteroids", which have been posited on the basis of biochemical, physiological, and behavioral studies.
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issn	0036-8075
language	eng
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source	American Association for the Advancement of Science; Jstor Complete Legacy
subjects	brain cytochrome P450scc
title	Neurosteroids: Cytochrome P-450 sub(scc) in rat brain
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