Effect of Long-Term Inhalation of Toner on Extracellular Matrix in the Lungs of Rats In Vivo

We assessed the effects of long-term inhalation of toner on the pathological changes and gene expression with the synthesis and degradation of collagenous extracellular matrix in a rat model. Female Wistar rats (10 wk old) were divided evenly into a high concentration exposure group (H: 15.2 mg/m3),...

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Veröffentlicht in:	Inhalation toxicology 2005-03, Vol.17 (3), p.153-159
Hauptverfasser:	Marimoto, Dr. Yasuo, Kim, Heungnam, Oyabu, Takako, Hirohashi, Masami, Nagatomo, Hiroko, Ogami, Akira, Yamato, Hiroshi, Higashi, Toshiaki, Tanaka, Isamu, Kasai, Takahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Animals Collagen Type I - biosynthesis Collagen Type I - genetics Extracellular Matrix - drug effects Female Gene Expression Regulation - drug effects Ink Lung - drug effects Lung - metabolism Lung - pathology Matrix Metalloproteinase 2 - biosynthesis Matrix Metalloproteinase 2 - genetics Microscopy, Electron, Scanning Printing Pulmonary Fibrosis - chemically induced Pulmonary Fibrosis - pathology Rats Rats, Wistar Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis Tissue Inhibitor of Metalloproteinase-2 - genetics Tissue Inhibitor of Metalloproteinase-2 - metabolism Toxicity Tests, Chronic Trachea - drug effects
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