Extrapolation of the Carcinogenic Potency of Fibers from Rats to Humans
In 1999 Berry published a model for mesothelioma incidence following fiber exposure. He concluded, that the influence of the solubility of fibers on the mesothelioma rate is 17 times higher in humans than in rats. This conclusion may be helpful for evaluating the carcinogenic risk from man-made vitr...
Gespeichert in:
| Veröffentlicht in: | Inhalation toxicology 2004-01, Vol.16 (11-12), p.801-807 |
|---|---|
| 1. Verfasser: | |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 807 |
|---|---|
| container_issue | 11-12 |
| container_start_page | 801 |
| container_title | Inhalation toxicology |
| container_volume | 16 |
| creator | Rodelsperger, Klaus |
| description | In 1999 Berry published a model for mesothelioma incidence following fiber exposure. He concluded, that the influence of the solubility of fibers on the mesothelioma rate is 17 times higher in humans than in rats. This conclusion may be helpful for evaluating the carcinogenic risk from man-made vitreous fibers, but it had little influence on some recent discussions. It has been demonstrated using this model, that in an injection experiment with rats, fibers with elimination constants of 0.1/year and 1/year-which would approximately correspond to crocidolite and perhaps ceramic fibers-differ in their mesothelioma risk only by a ratio of 3.2:1. In contrast, for humans exposed continuously from age 20 to age 60 a risk ratio of 4,750:1 is obtained. This result may be helpful for the assessment of the human cancer risk e.g., from exposure to refractory ceramic fibers. However, uncertainty is large, since the life-span of rats is too low to measure the elimination rate of bio-persistent fibers sufficiently. |
| doi_str_mv | 10.1080/08958370490505016 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_infor</sourceid><recordid>TN_cdi_proquest_miscellaneous_14719141</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>17765818</sourcerecordid><originalsourceid>FETCH-LOGICAL-c464t-f5fefc262b2dfdcadd786bc2d1d78e5b0ae8cc64dfc5e598a6f21699682c3f3a3</originalsourceid><addsrcrecordid>eNqFkEtLAzEUhYMotlZ_gBuZlbvRZB5JBt1I6UMoKKLrcCeT2CkzSU0yaP-9U1oQESp3cS-c7xwuB6FLgm8I5vgW8yLnKcNZgfN-CD1CQ4ILEjNakGM03OpxD_ABOvN-hTGmOGWnaED6TVmOh2g2-QoO1raBUFsTWR2FpYrG4GRt7LsytYyebVBGbrbatC6V85F2to1eIPgo2GjetWD8OTrR0Hh1sd8j9DadvI7n8eJp9jh-WMQyo1mIda6VlglNyqTSlYSqYpyWMqlIf6i8xKC4lDSrtMxVXnCgOiG0KChPZKpTSEfoepe7dvajUz6ItvZSNQ0YZTsvCGM054T_D2aMFCQjPUh2oHTWe6e0WLu6BbcRBIttzeJPzb3nah_ela2qfhz7XnvgfgfURlvXwqd1TSUCbBrrtAMjay_SQ_l3v-xLBU1YSnBKrGznTN_wge--AVIgnaE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>14719141</pqid></control><display><type>article</type><title>Extrapolation of the Carcinogenic Potency of Fibers from Rats to Humans</title><source>MEDLINE</source><source>Taylor & Francis Medical Library - CRKN</source><source>Taylor & Francis Journals Complete</source><creator>Rodelsperger, Klaus</creator><creatorcontrib>Rodelsperger, Klaus</creatorcontrib><description>In 1999 Berry published a model for mesothelioma incidence following fiber exposure. He concluded, that the influence of the solubility of fibers on the mesothelioma rate is 17 times higher in humans than in rats. This conclusion may be helpful for evaluating the carcinogenic risk from man-made vitreous fibers, but it had little influence on some recent discussions. It has been demonstrated using this model, that in an injection experiment with rats, fibers with elimination constants of 0.1/year and 1/year-which would approximately correspond to crocidolite and perhaps ceramic fibers-differ in their mesothelioma risk only by a ratio of 3.2:1. In contrast, for humans exposed continuously from age 20 to age 60 a risk ratio of 4,750:1 is obtained. This result may be helpful for the assessment of the human cancer risk e.g., from exposure to refractory ceramic fibers. However, uncertainty is large, since the life-span of rats is too low to measure the elimination rate of bio-persistent fibers sufficiently.</description><identifier>ISSN: 0895-8378</identifier><identifier>EISSN: 1091-7691</identifier><identifier>DOI: 10.1080/08958370490505016</identifier><identifier>PMID: 16036750</identifier><language>eng</language><publisher>England: Informa UK Ltd</publisher><subject>Animals ; Asbestos - toxicity ; Carcinogens - administration & dosage ; Carcinogens - pharmacokinetics ; Carcinogens - toxicity ; Ceramics - toxicity ; Half-Life ; Humans ; Lung Neoplasms - chemically induced ; Lung Neoplasms - pathology ; Mesothelioma - chemically induced ; Mesothelioma - pathology ; Mineral Fibers - toxicity ; Models, Statistical ; Rats ; Species Specificity</subject><ispartof>Inhalation toxicology, 2004-01, Vol.16 (11-12), p.801-807</ispartof><rights>2004 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c464t-f5fefc262b2dfdcadd786bc2d1d78e5b0ae8cc64dfc5e598a6f21699682c3f3a3</citedby><cites>FETCH-LOGICAL-c464t-f5fefc262b2dfdcadd786bc2d1d78e5b0ae8cc64dfc5e598a6f21699682c3f3a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/08958370490505016$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/08958370490505016$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/16036750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rodelsperger, Klaus</creatorcontrib><title>Extrapolation of the Carcinogenic Potency of Fibers from Rats to Humans</title><title>Inhalation toxicology</title><addtitle>Inhal Toxicol</addtitle><description>In 1999 Berry published a model for mesothelioma incidence following fiber exposure. He concluded, that the influence of the solubility of fibers on the mesothelioma rate is 17 times higher in humans than in rats. This conclusion may be helpful for evaluating the carcinogenic risk from man-made vitreous fibers, but it had little influence on some recent discussions. It has been demonstrated using this model, that in an injection experiment with rats, fibers with elimination constants of 0.1/year and 1/year-which would approximately correspond to crocidolite and perhaps ceramic fibers-differ in their mesothelioma risk only by a ratio of 3.2:1. In contrast, for humans exposed continuously from age 20 to age 60 a risk ratio of 4,750:1 is obtained. This result may be helpful for the assessment of the human cancer risk e.g., from exposure to refractory ceramic fibers. However, uncertainty is large, since the life-span of rats is too low to measure the elimination rate of bio-persistent fibers sufficiently.</description><subject>Animals</subject><subject>Asbestos - toxicity</subject><subject>Carcinogens - administration & dosage</subject><subject>Carcinogens - pharmacokinetics</subject><subject>Carcinogens - toxicity</subject><subject>Ceramics - toxicity</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Lung Neoplasms - chemically induced</subject><subject>Lung Neoplasms - pathology</subject><subject>Mesothelioma - chemically induced</subject><subject>Mesothelioma - pathology</subject><subject>Mineral Fibers - toxicity</subject><subject>Models, Statistical</subject><subject>Rats</subject><subject>Species Specificity</subject><issn>0895-8378</issn><issn>1091-7691</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLAzEUhYMotlZ_gBuZlbvRZB5JBt1I6UMoKKLrcCeT2CkzSU0yaP-9U1oQESp3cS-c7xwuB6FLgm8I5vgW8yLnKcNZgfN-CD1CQ4ILEjNakGM03OpxD_ABOvN-hTGmOGWnaED6TVmOh2g2-QoO1raBUFsTWR2FpYrG4GRt7LsytYyebVBGbrbatC6V85F2to1eIPgo2GjetWD8OTrR0Hh1sd8j9DadvI7n8eJp9jh-WMQyo1mIda6VlglNyqTSlYSqYpyWMqlIf6i8xKC4lDSrtMxVXnCgOiG0KChPZKpTSEfoepe7dvajUz6ItvZSNQ0YZTsvCGM054T_D2aMFCQjPUh2oHTWe6e0WLu6BbcRBIttzeJPzb3nah_ela2qfhz7XnvgfgfURlvXwqd1TSUCbBrrtAMjay_SQ_l3v-xLBU1YSnBKrGznTN_wge--AVIgnaE</recordid><startdate>20040101</startdate><enddate>20040101</enddate><creator>Rodelsperger, Klaus</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope><scope>7U7</scope></search><sort><creationdate>20040101</creationdate><title>Extrapolation of the Carcinogenic Potency of Fibers from Rats to Humans</title><author>Rodelsperger, Klaus</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c464t-f5fefc262b2dfdcadd786bc2d1d78e5b0ae8cc64dfc5e598a6f21699682c3f3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Asbestos - toxicity</topic><topic>Carcinogens - administration & dosage</topic><topic>Carcinogens - pharmacokinetics</topic><topic>Carcinogens - toxicity</topic><topic>Ceramics - toxicity</topic><topic>Half-Life</topic><topic>Humans</topic><topic>Lung Neoplasms - chemically induced</topic><topic>Lung Neoplasms - pathology</topic><topic>Mesothelioma - chemically induced</topic><topic>Mesothelioma - pathology</topic><topic>Mineral Fibers - toxicity</topic><topic>Models, Statistical</topic><topic>Rats</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rodelsperger, Klaus</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><collection>Toxicology Abstracts</collection><jtitle>Inhalation toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rodelsperger, Klaus</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Extrapolation of the Carcinogenic Potency of Fibers from Rats to Humans</atitle><jtitle>Inhalation toxicology</jtitle><addtitle>Inhal Toxicol</addtitle><date>2004-01-01</date><risdate>2004</risdate><volume>16</volume><issue>11-12</issue><spage>801</spage><epage>807</epage><pages>801-807</pages><issn>0895-8378</issn><eissn>1091-7691</eissn><abstract>In 1999 Berry published a model for mesothelioma incidence following fiber exposure. He concluded, that the influence of the solubility of fibers on the mesothelioma rate is 17 times higher in humans than in rats. This conclusion may be helpful for evaluating the carcinogenic risk from man-made vitreous fibers, but it had little influence on some recent discussions. It has been demonstrated using this model, that in an injection experiment with rats, fibers with elimination constants of 0.1/year and 1/year-which would approximately correspond to crocidolite and perhaps ceramic fibers-differ in their mesothelioma risk only by a ratio of 3.2:1. In contrast, for humans exposed continuously from age 20 to age 60 a risk ratio of 4,750:1 is obtained. This result may be helpful for the assessment of the human cancer risk e.g., from exposure to refractory ceramic fibers. However, uncertainty is large, since the life-span of rats is too low to measure the elimination rate of bio-persistent fibers sufficiently.</abstract><cop>England</cop><pub>Informa UK Ltd</pub><pmid>16036750</pmid><doi>10.1080/08958370490505016</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0895-8378 |
| ispartof | Inhalation toxicology, 2004-01, Vol.16 (11-12), p.801-807 |
| issn | 0895-8378 1091-7691 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14719141 |
| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Animals Asbestos - toxicity Carcinogens - administration & dosage Carcinogens - pharmacokinetics Carcinogens - toxicity Ceramics - toxicity Half-Life Humans Lung Neoplasms - chemically induced Lung Neoplasms - pathology Mesothelioma - chemically induced Mesothelioma - pathology Mineral Fibers - toxicity Models, Statistical Rats Species Specificity |
| title | Extrapolation of the Carcinogenic Potency of Fibers from Rats to Humans |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T10%3A53%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_infor&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Extrapolation%20of%20the%20Carcinogenic%20Potency%20of%20Fibers%20from%20Rats%20to%20Humans&rft.jtitle=Inhalation%20toxicology&rft.au=Rodelsperger,%20Klaus&rft.date=2004-01-01&rft.volume=16&rft.issue=11-12&rft.spage=801&rft.epage=807&rft.pages=801-807&rft.issn=0895-8378&rft.eissn=1091-7691&rft_id=info:doi/10.1080/08958370490505016&rft_dat=%3Cproquest_infor%3E17765818%3C/proquest_infor%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=14719141&rft_id=info:pmid/16036750&rfr_iscdi=true |