Passive immunization of mice with monoclonal antibodies raised against tick-borne encephalitis virus
Adult Balb/c mice were passively immunized with monoclonal antibodies (100 mu g/mouse) raised against tick-borne encephalitis (TBE) virus then challenged 24 hours later s.c. with 10 LD sub(50) of TBE virus (Neudorfl isolate). None of the mice showed evidence of premature death although all except on...
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| Veröffentlicht in: | Archives of virology 1987-01, Vol.93 (3/4), p.295-301 |
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| container_title | Archives of virology |
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| creator | Phillpotts, R.J Stephenson, J.R Porterfield, J.S |
| description | Adult Balb/c mice were passively immunized with monoclonal antibodies (100 mu g/mouse) raised against tick-borne encephalitis (TBE) virus then challenged 24 hours later s.c. with 10 LD sub(50) of TBE virus (Neudorfl isolate). None of the mice showed evidence of premature death although all except one of the monoclonal antibodies tested are capable of enhancing the infectivity of TBE virus in the Fc receptor-bearing mouse macrophage-like cell line P 388 D 1. The ability of monoclonal antibodies to neutralize TBE virus in vitro, and to fix complement was examined, and of these properties only a single monoclonal antibody, which was able to neutralize virus, was also able to protect mice against virus challenge. |
| doi_str_mv | 10.1007/BF01310983 |
| format | Article |
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None of the mice showed evidence of premature death although all except one of the monoclonal antibodies tested are capable of enhancing the infectivity of TBE virus in the Fc receptor-bearing mouse macrophage-like cell line P 388 D 1. The ability of monoclonal antibodies to neutralize TBE virus in vitro, and to fix complement was examined, and of these properties only a single monoclonal antibody, which was able to neutralize virus, was also able to protect mice against virus challenge.</description><identifier>ISSN: 0304-8608</identifier><identifier>EISSN: 1432-8798</identifier><identifier>DOI: 10.1007/BF01310983</identifier><language>eng</language><publisher>Wien: Springer</publisher><subject>Arboviroses ; Biological and medical sciences ; encephalitis ; Fundamental and applied biological sciences. Psychology ; Human viral diseases ; immunization ; Infectious diseases ; Medical sciences ; mice ; Microbiology ; monoclonal antibodies ; tick-borne diseases ; tick-borne encephalitis virus ; Tropical medicine ; Tropical viral diseases ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Viral diseases ; Virology ; Yellow fever</subject><ispartof>Archives of virology, 1987-01, Vol.93 (3/4), p.295-301</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c313t-d16ed31bbe71aeda7a68a0e0c903117b4a78fb4c27afb9ae6c10a38887d9640c3</citedby><cites>FETCH-LOGICAL-c313t-d16ed31bbe71aeda7a68a0e0c903117b4a78fb4c27afb9ae6c10a38887d9640c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8227315$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Phillpotts, R.J</creatorcontrib><creatorcontrib>Stephenson, J.R</creatorcontrib><creatorcontrib>Porterfield, J.S</creatorcontrib><title>Passive immunization of mice with monoclonal antibodies raised against tick-borne encephalitis virus</title><title>Archives of virology</title><description>Adult Balb/c mice were passively immunized with monoclonal antibodies (100 mu g/mouse) raised against tick-borne encephalitis (TBE) virus then challenged 24 hours later s.c. with 10 LD sub(50) of TBE virus (Neudorfl isolate). None of the mice showed evidence of premature death although all except one of the monoclonal antibodies tested are capable of enhancing the infectivity of TBE virus in the Fc receptor-bearing mouse macrophage-like cell line P 388 D 1. The ability of monoclonal antibodies to neutralize TBE virus in vitro, and to fix complement was examined, and of these properties only a single monoclonal antibody, which was able to neutralize virus, was also able to protect mice against virus challenge.</description><subject>Arboviroses</subject><subject>Biological and medical sciences</subject><subject>encephalitis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human viral diseases</subject><subject>immunization</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>mice</subject><subject>Microbiology</subject><subject>monoclonal antibodies</subject><subject>tick-borne diseases</subject><subject>tick-borne encephalitis virus</subject><subject>Tropical medicine</subject><subject>Tropical viral diseases</subject><subject>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</subject><subject>Viral diseases</subject><subject>Virology</subject><subject>Yellow fever</subject><issn>0304-8608</issn><issn>1432-8798</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><recordid>eNpFkEFP3DAQhS1UpG6BS_8APlQcKqWM42zsHAFBQUKiUuEcTZwJTJvYW0-Wqv31TbuInp709L3v8JR6b-CTAXCn51dgrIHG2z21MpUtC-8a_0atwEJV-Br8W_VO5BvAUtj1SvVfUISfSfM0bSP_xplT1GnQEwfSP3l-0lOKKYwp4qgxztylnkl0RhbqNT4iR5n1zOF70aUcSVMMtHnCkWcW_cx5K4dqf8BR6OglD9TD1eX9xXVxe_f55uLstgjW2LnoTU29NV1HziD16LD2CAShAWuM6yp0fuiqUDocugapDgbQeu9d39QVBHugTnbeTU4_tiRzO7EEGkeMlLbSmsqZem3WC_hxB4acRDIN7SbzhPlXa6D9e2T7_8gF_vBiRQk4DhljYHld-LJ09p_zeIcNmFp8zAvy8LVcLGCq0oNr7B8Qc31j</recordid><startdate>19870101</startdate><enddate>19870101</enddate><creator>Phillpotts, R.J</creator><creator>Stephenson, J.R</creator><creator>Porterfield, J.S</creator><general>Springer</general><scope>FBQ</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>19870101</creationdate><title>Passive immunization of mice with monoclonal antibodies raised against tick-borne encephalitis virus</title><author>Phillpotts, R.J ; Stephenson, J.R ; Porterfield, J.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-d16ed31bbe71aeda7a68a0e0c903117b4a78fb4c27afb9ae6c10a38887d9640c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Arboviroses</topic><topic>Biological and medical sciences</topic><topic>encephalitis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human viral diseases</topic><topic>immunization</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>mice</topic><topic>Microbiology</topic><topic>monoclonal antibodies</topic><topic>tick-borne diseases</topic><topic>tick-borne encephalitis virus</topic><topic>Tropical medicine</topic><topic>Tropical viral diseases</topic><topic>Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies</topic><topic>Viral diseases</topic><topic>Virology</topic><topic>Yellow fever</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Phillpotts, R.J</creatorcontrib><creatorcontrib>Stephenson, J.R</creatorcontrib><creatorcontrib>Porterfield, J.S</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Archives of virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Phillpotts, R.J</au><au>Stephenson, J.R</au><au>Porterfield, J.S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Passive immunization of mice with monoclonal antibodies raised against tick-borne encephalitis virus</atitle><jtitle>Archives of virology</jtitle><date>1987-01-01</date><risdate>1987</risdate><volume>93</volume><issue>3/4</issue><spage>295</spage><epage>301</epage><pages>295-301</pages><issn>0304-8608</issn><eissn>1432-8798</eissn><abstract>Adult Balb/c mice were passively immunized with monoclonal antibodies (100 mu g/mouse) raised against tick-borne encephalitis (TBE) virus then challenged 24 hours later s.c. with 10 LD sub(50) of TBE virus (Neudorfl isolate). None of the mice showed evidence of premature death although all except one of the monoclonal antibodies tested are capable of enhancing the infectivity of TBE virus in the Fc receptor-bearing mouse macrophage-like cell line P 388 D 1. The ability of monoclonal antibodies to neutralize TBE virus in vitro, and to fix complement was examined, and of these properties only a single monoclonal antibody, which was able to neutralize virus, was also able to protect mice against virus challenge.</abstract><cop>Wien</cop><cop>New York, NY</cop><pub>Springer</pub><doi>10.1007/BF01310983</doi><tpages>7</tpages></addata></record> |
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| ispartof | Archives of virology, 1987-01, Vol.93 (3/4), p.295-301 |
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| language | eng |
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| subjects | Arboviroses Biological and medical sciences encephalitis Fundamental and applied biological sciences. Psychology Human viral diseases immunization Infectious diseases Medical sciences mice Microbiology monoclonal antibodies tick-borne diseases tick-borne encephalitis virus Tropical medicine Tropical viral diseases Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Viral diseases Virology Yellow fever |
| title | Passive immunization of mice with monoclonal antibodies raised against tick-borne encephalitis virus |
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