Fusion as a mediator of cytolysis in mixtures of uninfected CD4 super(+) lymphocytes and cells infected by human immunodeficiency virus

Fusion as a mediator of cytolysis in mixtures of uninfected CD4 super(+) lymphocytes and cells infected by human immunodeficiency virus

The authors describe an unusual type of cytopathology in which uninfected CD4 super(+) (helper/inducer) cells (cells expressing the human leukocyte antigen CD4) interact with cells persistently infected with the human immunodeficiency virus (HIV). The data may explain the paradox that exists in vivo...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 1987-01, Vol.84 (5), p.1429-1433
Hauptverfasser: Yoffe, B, Lewis, DE, Petrie, B L, Noonan, CA, Melnick, J L, Hollinger, F B
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container_end_page 1433
container_issue 5
container_start_page 1429
container_title Proceedings of the National Academy of Sciences - PNAS
container_volume 84
creator Yoffe, B
Lewis, DE
Petrie, B L
Noonan, CA
Melnick, J L
Hollinger, F B
description The authors describe an unusual type of cytopathology in which uninfected CD4 super(+) (helper/inducer) cells (cells expressing the human leukocyte antigen CD4) interact with cells persistently infected with the human immunodeficiency virus (HIV). The data may explain the paradox that exists in vivo in which a dramatic depletion of CD4 super(+) lymphocytes occurs in the presence of a small number of HIV-infected CD4 super(+) cells. These new insights into the pathogenesis of acquired immunodeficiency syndrome (AIDS) may lead to future therapeutic strategies.
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title Fusion as a mediator of cytolysis in mixtures of uninfected CD4 super(+) lymphocytes and cells infected by human immunodeficiency virus
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