Phorbol ester-mediated inhibition of vasopressin and beta-adrenergic responses in a vascular smooth muscle cell line

We have reported previously that in the vascular smooth muscle cell line A-10 (ATCC CRL 1476), vasopressin stimulated phosphatidylinositol turnover Ca2+ efflux and inhibited isoproterenol-stimulated cAMP accumulation. Here we report that pretreatment of these cells with phorbol dibutyrate, an activa...

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Veröffentlicht in:	Molecular pharmacology 1987-02, Vol.31 (2), p.180-184
Hauptverfasser:	AIYAR, N, NAMBI, P, WHITMAN, M, STASSEN, F. L, CROOKE, S. T
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginine Vasopressin - antagonists & inhibitors Biological and medical sciences blood vessels Blood vessels and receptors Calcium - metabolism Cell Line Cyclic AMP - metabolism Fundamental and applied biological sciences. Psychology guanine nucleotide-binding protein Inositol Phosphates - metabolism Isoproterenol - antagonists & inhibitors Isoproterenol - pharmacology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - physiology Phorbol Esters - pharmacology Phosphatidylinositols - metabolism protein kinase C Protein Kinase C - physiology Rats Receptors, Adrenergic, beta - physiology Receptors, Angiotensin - physiology Receptors, Vasopressin smooth muscle vasopressin Vertebrates: cardiovascular system
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