Asymmetric synthesis of drug-like spiro[chroman-3,3'-indolin]-2'-ones through aminal-catalysis

Asymmetric synthesis of drug-like functionalized spiro[chroman-3,3'-indolin]-2'-ones 5 containing three contiguous stereocenters with high diastereo- and enantioselectivities was achieved using the reflexive-Michael (r-M) reaction of unmodified hydroxyenals 1 with various (E)-3-alkylidenei...

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Veröffentlicht in:	Organic & biomolecular chemistry 2014-01, Vol.12 (4), p.574-580
Hauptverfasser:	Ramachary, Dhevalapally B, Prasad, M Shiva, Laxmi, S Vijaya, Madhavachary, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines - chemistry Catalysis Indoles - chemical synthesis Indoles - chemistry Molecular Structure Spiro Compounds - chemical synthesis Spiro Compounds - chemistry Stereoisomerism
Online-Zugang:	Volltext
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