Imperfect coordination chemistry facilitates metal ion release in the Psa permease

The PsaA binding protein delivers Mn 2+ to the human pathogen Streptococcus pneumoniae . Structural and biochemical studies now explain its metal specificity, showing that metal binding induces a closed complex that is reversible for the desired substrate but irreversible for the inhibitor Zn 2+ . T...

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Veröffentlicht in:	Nature chemical biology 2014-01, Vol.10 (1), p.35-41
Hauptverfasser:	Couñago, Rafael M, Ween, Miranda P, Begg, Stephanie L, Bajaj, Megha, Zuegg, Johannes, O'Mara, Megan L, Cooper, Matthew A, McEwan, Alastair G, Paton, James C, Kobe, Bostjan, McDevitt, Christopher A
Format:	Artikel
Sprache:	eng
Schlagworte:	38/70 631/326/41 631/535/1266 631/92/577 631/92/612/1141 82/83 Binding Sites Biochemical Engineering Biochemistry Bioorganic Chemistry Cations Cell Biology Chemistry Chemistry/Food Science Enzymes Manganese Membrane Transport Proteins - chemistry Membrane Transport Proteins - metabolism Metal ions Metals - metabolism Models, Molecular Molecular chemistry Physiology Proteins Streptococcus pneumoniae - metabolism Substrates Trace elements Zinc
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