In Vivo Multimodality Imaging and Cancer Therapy by Near-Infrared Light-Triggered trans-Platinum Pro-Drug-Conjugated Upconverison Nanoparticles

Controlling anticancer drug activity and release on demand is very significant in cancer therapy. The photoactivated platinum(IV) pro-drug is stable in the dark and can be activated by UV light. In this study, we develop a multifunctional drug delivery system combining upconversion luminescence/mag...

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Veröffentlicht in:	Journal of the American Chemical Society 2013-12, Vol.135 (50), p.18920-18929
Hauptverfasser:	Dai, Yunlu, Xiao, Haihua, Liu, Jianhua, Yuan, Qinghai, Ma, Ping’an, Yang, Dongmei, Li, Chunxia, Cheng, Ziyong, Hou, Zhiyao, Yang, Piaoping, Lin, Jun
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Sprache:	eng
Schlagworte:	Humans Magnetic Resonance Imaging Microscopy, Electron, Transmission Multimodal Imaging Nanoparticles Neoplasms - therapy Platinum - administration & dosage Prodrugs - administration & dosage Spectrophotometry, Ultraviolet Tomography, X-Ray Computed
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container_title	Journal of the American Chemical Society
container_volume	135
creator	Dai, Yunlu Xiao, Haihua Liu, Jianhua Yuan, Qinghai Ma, Ping’an Yang, Dongmei Li, Chunxia Cheng, Ziyong Hou, Zhiyao Yang, Piaoping Lin, Jun
description	Controlling anticancer drug activity and release on demand is very significant in cancer therapy. The photoactivated platinum(IV) pro-drug is stable in the dark and can be activated by UV light. In this study, we develop a multifunctional drug delivery system combining upconversion luminescence/magnetic resonance/computer tomography trimodality imaging and NIR-activated platinum pro-drug delivery. We use the core–shell structured upconversion nanoparticles to convert the absorbed NIR light into UV to activate the trans-platinum(IV) pro-drug, trans,trans,trans-[Pt(N3)2(NH3)(py)(O2CCH2CH2COOH)2]. Compared with using the UV directly, the NIR has a higher tissue penetration depth and is less harmful to health. Meanwhile, the upconversion nanoparticles can effectively deliver the platinum(IV) pro-drugs into the cells by endocytosis. The mice treated with pro-drug-conjugated nanoparticles under near-infrared (NIR) irradiation demonstrated better inhibition of tumor growth than that under direct UV irradiation. This multifunctional nanocomposite could be used as multimodality bioimaging contrast agents and transducers by converting NIR light into UV for control of drug activity in practical cancer therapy.
doi_str_mv	10.1021/ja410028q
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The photoactivated platinum(IV) pro-drug is stable in the dark and can be activated by UV light. In this study, we develop a multifunctional drug delivery system combining upconversion luminescence/magnetic resonance/computer tomography trimodality imaging and NIR-activated platinum pro-drug delivery. We use the core–shell structured upconversion nanoparticles to convert the absorbed NIR light into UV to activate the trans-platinum(IV) pro-drug, trans,trans,trans-[Pt(N3)2(NH3)(py)(O2CCH2CH2COOH)2]. Compared with using the UV directly, the NIR has a higher tissue penetration depth and is less harmful to health. Meanwhile, the upconversion nanoparticles can effectively deliver the platinum(IV) pro-drugs into the cells by endocytosis. The mice treated with pro-drug-conjugated nanoparticles under near-infrared (NIR) irradiation demonstrated better inhibition of tumor growth than that under direct UV irradiation. 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Am. Chem. Soc</addtitle><description>Controlling anticancer drug activity and release on demand is very significant in cancer therapy. The photoactivated platinum(IV) pro-drug is stable in the dark and can be activated by UV light. In this study, we develop a multifunctional drug delivery system combining upconversion luminescence/magnetic resonance/computer tomography trimodality imaging and NIR-activated platinum pro-drug delivery. We use the core–shell structured upconversion nanoparticles to convert the absorbed NIR light into UV to activate the trans-platinum(IV) pro-drug, trans,trans,trans-[Pt(N3)2(NH3)(py)(O2CCH2CH2COOH)2]. Compared with using the UV directly, the NIR has a higher tissue penetration depth and is less harmful to health. Meanwhile, the upconversion nanoparticles can effectively deliver the platinum(IV) pro-drugs into the cells by endocytosis. The mice treated with pro-drug-conjugated nanoparticles under near-infrared (NIR) irradiation demonstrated better inhibition of tumor growth than that under direct UV irradiation. This multifunctional nanocomposite could be used as multimodality bioimaging contrast agents and transducers by converting NIR light into UV for control of drug activity in practical cancer therapy.</description><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Microscopy, Electron, Transmission</subject><subject>Multimodal Imaging</subject><subject>Nanoparticles</subject><subject>Neoplasms - therapy</subject><subject>Platinum - administration & dosage</subject><subject>Prodrugs - administration & dosage</subject><subject>Spectrophotometry, Ultraviolet</subject><subject>Tomography, X-Ray Computed</subject><issn>0002-7863</issn><issn>1520-5126</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0MFO3DAQBmCroioL7aEvgHxBKgcX2_HGyREtBVbaAoel12jWcYJXiR3GDtI-Ba_coAVOnEYz-vRL8xPyU_DfgktxvgUlOJfF0xcyE3PJ2VzI_IDM-HRkusizQ3IU43ZalSzEN3IoldRlJvIZeVl6-s89B_p37JLrQw2dSzu67KF1vqXga7oAbyzS9aNFGHZ0s6O3FpAtfYOAtqYr1z4mtkbXtvZ1Twg-svsOkvNjT-8xsEscW7YIfju2kCbyMJjgny26GDy9BR8GwORMZ-N38rWBLtofb_OYPFz9WS9u2Oruerm4WDHICpGY1BqgyTdzzrUxOS_BgGlK0HPNldbClMaoAgrLDTdF1oCUkGd1YzkIKRVkx-TXPnfA8DTamKreRWO7DrwNY6yEystclUpmEz3bU4MhRrRNNaDrAXeV4NVr_9VH_5M9eYsdN72tP-R74RM43QMwsdqGEf305SdB_wExVI6f</recordid><startdate>20131218</startdate><enddate>20131218</enddate><creator>Dai, Yunlu</creator><creator>Xiao, Haihua</creator><creator>Liu, Jianhua</creator><creator>Yuan, Qinghai</creator><creator>Ma, Ping’an</creator><creator>Yang, Dongmei</creator><creator>Li, Chunxia</creator><creator>Cheng, Ziyong</creator><creator>Hou, Zhiyao</creator><creator>Yang, Piaoping</creator><creator>Lin, Jun</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131218</creationdate><title>In Vivo Multimodality Imaging and Cancer Therapy by Near-Infrared Light-Triggered trans-Platinum Pro-Drug-Conjugated Upconverison Nanoparticles</title><author>Dai, Yunlu ; Xiao, Haihua ; Liu, Jianhua ; Yuan, Qinghai ; Ma, Ping’an ; Yang, Dongmei ; Li, Chunxia ; Cheng, Ziyong ; Hou, Zhiyao ; Yang, Piaoping ; Lin, Jun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a381t-277aaf6b5007cc609acacf9a75704771c9cc48a8e0c0c83fa22a63dfe0a1224a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Microscopy, Electron, Transmission</topic><topic>Multimodal Imaging</topic><topic>Nanoparticles</topic><topic>Neoplasms - therapy</topic><topic>Platinum - administration & dosage</topic><topic>Prodrugs - administration & dosage</topic><topic>Spectrophotometry, Ultraviolet</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dai, Yunlu</creatorcontrib><creatorcontrib>Xiao, Haihua</creatorcontrib><creatorcontrib>Liu, Jianhua</creatorcontrib><creatorcontrib>Yuan, Qinghai</creatorcontrib><creatorcontrib>Ma, Ping’an</creatorcontrib><creatorcontrib>Yang, Dongmei</creatorcontrib><creatorcontrib>Li, Chunxia</creatorcontrib><creatorcontrib>Cheng, Ziyong</creatorcontrib><creatorcontrib>Hou, Zhiyao</creatorcontrib><creatorcontrib>Yang, Piaoping</creatorcontrib><creatorcontrib>Lin, Jun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dai, Yunlu</au><au>Xiao, Haihua</au><au>Liu, Jianhua</au><au>Yuan, Qinghai</au><au>Ma, Ping’an</au><au>Yang, Dongmei</au><au>Li, Chunxia</au><au>Cheng, Ziyong</au><au>Hou, Zhiyao</au><au>Yang, Piaoping</au><au>Lin, Jun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In Vivo Multimodality Imaging and Cancer Therapy by Near-Infrared Light-Triggered trans-Platinum Pro-Drug-Conjugated Upconverison Nanoparticles</atitle><jtitle>Journal of the American Chemical Society</jtitle><addtitle>J. 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subjects	Humans Magnetic Resonance Imaging Microscopy, Electron, Transmission Multimodal Imaging Nanoparticles Neoplasms - therapy Platinum - administration & dosage Prodrugs - administration & dosage Spectrophotometry, Ultraviolet Tomography, X-Ray Computed
title	In Vivo Multimodality Imaging and Cancer Therapy by Near-Infrared Light-Triggered trans-Platinum Pro-Drug-Conjugated Upconverison Nanoparticles
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