Xenon computed tomography can evaluate the improvement of hepatic hemodynamics before and after endoscopic injection sclerotherapy
Background Xenon computed tomography (Xe-CT) provides quantitative information on tissue blood flow (TBF). In the present study, Xe-CT was performed in patients with esophagogastric varices (EGV) before and after endoscopic injection sclerotherapy (EIS) to evaluate hepatic blood flow (HBF), hepatic...
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| Veröffentlicht in: | Journal of gastroenterology 2013-12, Vol.48 (12), p.1353-1361 |
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| creator | Takahashi, Hideaki Suzuki, Michihiro Shigefuku, Ryuta Okano, Miki Hiraishi, Tetsuya Takagi, Rei Noguchi, Yohei Hattori, Nobuhiro Hatsugai, Moriaki Nakahara, Kazunari Okamoto, Masaru Kobayashi, Minoru Ikeda, Hiroki Fukuda, Yasunobu Nagase, Yoshihiko Ishii, Toshiya Matsunaga, Kotaro Matsumoto, Nobuyuki Okuse, Chiaki Sase, Shigeru Itoh, Fumio |
| description | Background
Xenon computed tomography (Xe-CT) provides quantitative information on tissue blood flow (TBF). In the present study, Xe-CT was performed in patients with esophagogastric varices (EGV) before and after endoscopic injection sclerotherapy (EIS) to evaluate hepatic blood flow (HBF), hepatic arterial TBF (HATBF) and portal venous TBF (PVTBF).
Methods
Subjects comprised of 88 patients with EGV (49 men, 39 women, average age 65.8 ± 11.5 years, median age 68 years, 30–86 years) and liver cirrhosis related to either hepatitis C virus (C) (
n
= 33), hepatitis B virus (B) (
n
= 3), alcohol (AL) (
n
= 22), AL + C (
n
= 7), AL + B (
n
= 1), B + C + AL (
n
= 1), nonalcoholic steatohepatitis (NASH) (
n
= 4), autoimmune hepatitis (AIH) (
n
= 5), primary biliary cirrhosis (PBC) (
n
= 2), or cryptogenic (
n
= 10) were enrolled. All patients, who were enrolled in this study, were performed EIS for prophylaxis. Xe-CT and measurement of the retention rate of indocyanine green 15 min after administration (ICG R15) were performed before and after EIS. Total hepatic TBF (THTBF) and PVTBF/HATBF ratio (P/A) were also calculated.
Results
PVTBF, HATBF, THTBF, P/A and ICG R15 before EIS were 28.3 ± 8.91, 22.5 ± 14.4 and 50.8 ± 17.6 ml/100 ml/min, 1.62 ± 0.71 and 28.8 ± 12.7 %, respectively and those after EIS were 31.9 ± 10.0, 19.3 ± 11.6, and 51.2 ± 17.0 ml/100 ml/min, 1.92 ± 0.84 and 23.6 ± 11.3 %, respectively. PVTBF and P/A after EIS were significantly higher than those before EIS (
p
= 0.00444,
p
= 0.0179, respectively), and HATBF and ICG R15 after EIS were significantly lower than those before EIS (
p
= 0.00129,
p
|
| doi_str_mv | 10.1007/s00535-013-0756-7 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1469646208</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A714584173</galeid><sourcerecordid>A714584173</sourcerecordid><originalsourceid>FETCH-LOGICAL-c529t-bd54d1b0edd696d768cdf94a0214f1b1eb4c6d0c68b6e2aed31f811990790b523</originalsourceid><addsrcrecordid>eNp1kU1r3DAQhk1paLZpf0AvRdBLL041tmzZxxD6BYFeGshNyNJo14stuZIc2Gt_eWfZNP2gRYeBmWfemdFbFK-AXwLn8l3ivKmbkkNdctm0pXxSbEBQpumr6mmx4b0QJYAU58XzlPacQN50z4rzqq57SYVN8f0OffDMhHlZM1qWwxy2US-7AzPaM7zX06ozsrxDNs5LDPc4o88sOLbDRefRUJyDPXg9jyaxAV2IyLS3TLuMkaG3IZmwEDj6PZo80rhkJoyBNGnS4UVx5vSU8OVDvChuP7z_ev2pvPny8fP11U1pmqrP5WAbYWHgaG3bt1a2nbGuF5pXIBwMgIMwreWm7YYWK422BtcB9D2XPR-aqr4o3p506YpvK6as5jEZnCbtMaxJgSBd0Va8I_TNX-g-rNHTdkeq64BDK35RWz2hGr0LOWpzFFVXEkTTCZA1UZf_oOhZpB8LHt1I-T8a4NRgYkgpolNLHGcdDwq4OvquTr4rslMdfVeSel4_LLwOM9rHjp9GE1CdgEQlv8X420X_Vf0BUBW5Rw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1468810164</pqid></control><display><type>article</type><title>Xenon computed tomography can evaluate the improvement of hepatic hemodynamics before and after endoscopic injection sclerotherapy</title><source>MEDLINE</source><source>Springer Online Journals Complete</source><creator>Takahashi, Hideaki ; Suzuki, Michihiro ; Shigefuku, Ryuta ; Okano, Miki ; Hiraishi, Tetsuya ; Takagi, Rei ; Noguchi, Yohei ; Hattori, Nobuhiro ; Hatsugai, Moriaki ; Nakahara, Kazunari ; Okamoto, Masaru ; Kobayashi, Minoru ; Ikeda, Hiroki ; Fukuda, Yasunobu ; Nagase, Yoshihiko ; Ishii, Toshiya ; Matsunaga, Kotaro ; Matsumoto, Nobuyuki ; Okuse, Chiaki ; Sase, Shigeru ; Itoh, Fumio</creator><creatorcontrib>Takahashi, Hideaki ; Suzuki, Michihiro ; Shigefuku, Ryuta ; Okano, Miki ; Hiraishi, Tetsuya ; Takagi, Rei ; Noguchi, Yohei ; Hattori, Nobuhiro ; Hatsugai, Moriaki ; Nakahara, Kazunari ; Okamoto, Masaru ; Kobayashi, Minoru ; Ikeda, Hiroki ; Fukuda, Yasunobu ; Nagase, Yoshihiko ; Ishii, Toshiya ; Matsunaga, Kotaro ; Matsumoto, Nobuyuki ; Okuse, Chiaki ; Sase, Shigeru ; Itoh, Fumio</creatorcontrib><description>Background
Xenon computed tomography (Xe-CT) provides quantitative information on tissue blood flow (TBF). In the present study, Xe-CT was performed in patients with esophagogastric varices (EGV) before and after endoscopic injection sclerotherapy (EIS) to evaluate hepatic blood flow (HBF), hepatic arterial TBF (HATBF) and portal venous TBF (PVTBF).
Methods
Subjects comprised of 88 patients with EGV (49 men, 39 women, average age 65.8 ± 11.5 years, median age 68 years, 30–86 years) and liver cirrhosis related to either hepatitis C virus (C) (
n
= 33), hepatitis B virus (B) (
n
= 3), alcohol (AL) (
n
= 22), AL + C (
n
= 7), AL + B (
n
= 1), B + C + AL (
n
= 1), nonalcoholic steatohepatitis (NASH) (
n
= 4), autoimmune hepatitis (AIH) (
n
= 5), primary biliary cirrhosis (PBC) (
n
= 2), or cryptogenic (
n
= 10) were enrolled. All patients, who were enrolled in this study, were performed EIS for prophylaxis. Xe-CT and measurement of the retention rate of indocyanine green 15 min after administration (ICG R15) were performed before and after EIS. Total hepatic TBF (THTBF) and PVTBF/HATBF ratio (P/A) were also calculated.
Results
PVTBF, HATBF, THTBF, P/A and ICG R15 before EIS were 28.3 ± 8.91, 22.5 ± 14.4 and 50.8 ± 17.6 ml/100 ml/min, 1.62 ± 0.71 and 28.8 ± 12.7 %, respectively and those after EIS were 31.9 ± 10.0, 19.3 ± 11.6, and 51.2 ± 17.0 ml/100 ml/min, 1.92 ± 0.84 and 23.6 ± 11.3 %, respectively. PVTBF and P/A after EIS were significantly higher than those before EIS (
p
= 0.00444,
p
= 0.0179, respectively), and HATBF and ICG R15 after EIS were significantly lower than those before EIS (
p
= 0.00129,
p
< 0.001, respectively).
Conclusions
Xenon computed tomography showed that PVTBF increased after EIS for EGV and HATBF decreased in response to an increase in PVTBF.</description><identifier>ISSN: 0944-1174</identifier><identifier>EISSN: 1435-5922</identifier><identifier>DOI: 10.1007/s00535-013-0756-7</identifier><identifier>PMID: 23397117</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Abdominal Surgery ; Adult ; Aged ; Aged, 80 and over ; Biliary Tract ; Colorectal Surgery ; CT imaging ; Endoscopy - methods ; Esophageal and Gastric Varices - pathology ; Esophageal and Gastric Varices - therapy ; Female ; Gastroenterology ; Hepatic Artery - metabolism ; Hepatitis B ; Hepatitis C virus ; Hepatology ; Humans ; Liver ; Liver - blood supply ; Liver - pathology ; Liver cirrhosis ; Liver Cirrhosis - etiology ; Liver Cirrhosis - pathology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article—Liver ; Pancreas ; Portal Vein - metabolism ; Prospective Studies ; Regional Blood Flow ; Sclerotherapy - methods ; Surgical Oncology ; Tomography, X-Ray Computed - methods ; Xenon</subject><ispartof>Journal of gastroenterology, 2013-12, Vol.48 (12), p.1353-1361</ispartof><rights>Springer Japan 2013</rights><rights>COPYRIGHT 2013 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-bd54d1b0edd696d768cdf94a0214f1b1eb4c6d0c68b6e2aed31f811990790b523</citedby><cites>FETCH-LOGICAL-c529t-bd54d1b0edd696d768cdf94a0214f1b1eb4c6d0c68b6e2aed31f811990790b523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00535-013-0756-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00535-013-0756-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23397117$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takahashi, Hideaki</creatorcontrib><creatorcontrib>Suzuki, Michihiro</creatorcontrib><creatorcontrib>Shigefuku, Ryuta</creatorcontrib><creatorcontrib>Okano, Miki</creatorcontrib><creatorcontrib>Hiraishi, Tetsuya</creatorcontrib><creatorcontrib>Takagi, Rei</creatorcontrib><creatorcontrib>Noguchi, Yohei</creatorcontrib><creatorcontrib>Hattori, Nobuhiro</creatorcontrib><creatorcontrib>Hatsugai, Moriaki</creatorcontrib><creatorcontrib>Nakahara, Kazunari</creatorcontrib><creatorcontrib>Okamoto, Masaru</creatorcontrib><creatorcontrib>Kobayashi, Minoru</creatorcontrib><creatorcontrib>Ikeda, Hiroki</creatorcontrib><creatorcontrib>Fukuda, Yasunobu</creatorcontrib><creatorcontrib>Nagase, Yoshihiko</creatorcontrib><creatorcontrib>Ishii, Toshiya</creatorcontrib><creatorcontrib>Matsunaga, Kotaro</creatorcontrib><creatorcontrib>Matsumoto, Nobuyuki</creatorcontrib><creatorcontrib>Okuse, Chiaki</creatorcontrib><creatorcontrib>Sase, Shigeru</creatorcontrib><creatorcontrib>Itoh, Fumio</creatorcontrib><title>Xenon computed tomography can evaluate the improvement of hepatic hemodynamics before and after endoscopic injection sclerotherapy</title><title>Journal of gastroenterology</title><addtitle>J Gastroenterol</addtitle><addtitle>J Gastroenterol</addtitle><description>Background
Xenon computed tomography (Xe-CT) provides quantitative information on tissue blood flow (TBF). In the present study, Xe-CT was performed in patients with esophagogastric varices (EGV) before and after endoscopic injection sclerotherapy (EIS) to evaluate hepatic blood flow (HBF), hepatic arterial TBF (HATBF) and portal venous TBF (PVTBF).
Methods
Subjects comprised of 88 patients with EGV (49 men, 39 women, average age 65.8 ± 11.5 years, median age 68 years, 30–86 years) and liver cirrhosis related to either hepatitis C virus (C) (
n
= 33), hepatitis B virus (B) (
n
= 3), alcohol (AL) (
n
= 22), AL + C (
n
= 7), AL + B (
n
= 1), B + C + AL (
n
= 1), nonalcoholic steatohepatitis (NASH) (
n
= 4), autoimmune hepatitis (AIH) (
n
= 5), primary biliary cirrhosis (PBC) (
n
= 2), or cryptogenic (
n
= 10) were enrolled. All patients, who were enrolled in this study, were performed EIS for prophylaxis. Xe-CT and measurement of the retention rate of indocyanine green 15 min after administration (ICG R15) were performed before and after EIS. Total hepatic TBF (THTBF) and PVTBF/HATBF ratio (P/A) were also calculated.
Results
PVTBF, HATBF, THTBF, P/A and ICG R15 before EIS were 28.3 ± 8.91, 22.5 ± 14.4 and 50.8 ± 17.6 ml/100 ml/min, 1.62 ± 0.71 and 28.8 ± 12.7 %, respectively and those after EIS were 31.9 ± 10.0, 19.3 ± 11.6, and 51.2 ± 17.0 ml/100 ml/min, 1.92 ± 0.84 and 23.6 ± 11.3 %, respectively. PVTBF and P/A after EIS were significantly higher than those before EIS (
p
= 0.00444,
p
= 0.0179, respectively), and HATBF and ICG R15 after EIS were significantly lower than those before EIS (
p
= 0.00129,
p
< 0.001, respectively).
Conclusions
Xenon computed tomography showed that PVTBF increased after EIS for EGV and HATBF decreased in response to an increase in PVTBF.</description><subject>Abdominal Surgery</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biliary Tract</subject><subject>Colorectal Surgery</subject><subject>CT imaging</subject><subject>Endoscopy - methods</subject><subject>Esophageal and Gastric Varices - pathology</subject><subject>Esophageal and Gastric Varices - therapy</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Hepatic Artery - metabolism</subject><subject>Hepatitis B</subject><subject>Hepatitis C virus</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Liver</subject><subject>Liver - blood supply</subject><subject>Liver - pathology</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - etiology</subject><subject>Liver Cirrhosis - pathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article—Liver</subject><subject>Pancreas</subject><subject>Portal Vein - metabolism</subject><subject>Prospective Studies</subject><subject>Regional Blood Flow</subject><subject>Sclerotherapy - methods</subject><subject>Surgical Oncology</subject><subject>Tomography, X-Ray Computed - methods</subject><subject>Xenon</subject><issn>0944-1174</issn><issn>1435-5922</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kU1r3DAQhk1paLZpf0AvRdBLL041tmzZxxD6BYFeGshNyNJo14stuZIc2Gt_eWfZNP2gRYeBmWfemdFbFK-AXwLn8l3ivKmbkkNdctm0pXxSbEBQpumr6mmx4b0QJYAU58XzlPacQN50z4rzqq57SYVN8f0OffDMhHlZM1qWwxy2US-7AzPaM7zX06ozsrxDNs5LDPc4o88sOLbDRefRUJyDPXg9jyaxAV2IyLS3TLuMkaG3IZmwEDj6PZo80rhkJoyBNGnS4UVx5vSU8OVDvChuP7z_ev2pvPny8fP11U1pmqrP5WAbYWHgaG3bt1a2nbGuF5pXIBwMgIMwreWm7YYWK422BtcB9D2XPR-aqr4o3p506YpvK6as5jEZnCbtMaxJgSBd0Va8I_TNX-g-rNHTdkeq64BDK35RWz2hGr0LOWpzFFVXEkTTCZA1UZf_oOhZpB8LHt1I-T8a4NRgYkgpolNLHGcdDwq4OvquTr4rslMdfVeSel4_LLwOM9rHjp9GE1CdgEQlv8X420X_Vf0BUBW5Rw</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Takahashi, Hideaki</creator><creator>Suzuki, Michihiro</creator><creator>Shigefuku, Ryuta</creator><creator>Okano, Miki</creator><creator>Hiraishi, Tetsuya</creator><creator>Takagi, Rei</creator><creator>Noguchi, Yohei</creator><creator>Hattori, Nobuhiro</creator><creator>Hatsugai, Moriaki</creator><creator>Nakahara, Kazunari</creator><creator>Okamoto, Masaru</creator><creator>Kobayashi, Minoru</creator><creator>Ikeda, Hiroki</creator><creator>Fukuda, Yasunobu</creator><creator>Nagase, Yoshihiko</creator><creator>Ishii, Toshiya</creator><creator>Matsunaga, Kotaro</creator><creator>Matsumoto, Nobuyuki</creator><creator>Okuse, Chiaki</creator><creator>Sase, Shigeru</creator><creator>Itoh, Fumio</creator><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20131201</creationdate><title>Xenon computed tomography can evaluate the improvement of hepatic hemodynamics before and after endoscopic injection sclerotherapy</title><author>Takahashi, Hideaki ; Suzuki, Michihiro ; Shigefuku, Ryuta ; Okano, Miki ; Hiraishi, Tetsuya ; Takagi, Rei ; Noguchi, Yohei ; Hattori, Nobuhiro ; Hatsugai, Moriaki ; Nakahara, Kazunari ; Okamoto, Masaru ; Kobayashi, Minoru ; Ikeda, Hiroki ; Fukuda, Yasunobu ; Nagase, Yoshihiko ; Ishii, Toshiya ; Matsunaga, Kotaro ; Matsumoto, Nobuyuki ; Okuse, Chiaki ; Sase, Shigeru ; Itoh, Fumio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-bd54d1b0edd696d768cdf94a0214f1b1eb4c6d0c68b6e2aed31f811990790b523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Abdominal Surgery</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Biliary Tract</topic><topic>Colorectal Surgery</topic><topic>CT imaging</topic><topic>Endoscopy - methods</topic><topic>Esophageal and Gastric Varices - pathology</topic><topic>Esophageal and Gastric Varices - therapy</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Hepatic Artery - metabolism</topic><topic>Hepatitis B</topic><topic>Hepatitis C virus</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Liver</topic><topic>Liver - blood supply</topic><topic>Liver - pathology</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - etiology</topic><topic>Liver Cirrhosis - pathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article—Liver</topic><topic>Pancreas</topic><topic>Portal Vein - metabolism</topic><topic>Prospective Studies</topic><topic>Regional Blood Flow</topic><topic>Sclerotherapy - methods</topic><topic>Surgical Oncology</topic><topic>Tomography, X-Ray Computed - methods</topic><topic>Xenon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takahashi, Hideaki</creatorcontrib><creatorcontrib>Suzuki, Michihiro</creatorcontrib><creatorcontrib>Shigefuku, Ryuta</creatorcontrib><creatorcontrib>Okano, Miki</creatorcontrib><creatorcontrib>Hiraishi, Tetsuya</creatorcontrib><creatorcontrib>Takagi, Rei</creatorcontrib><creatorcontrib>Noguchi, Yohei</creatorcontrib><creatorcontrib>Hattori, Nobuhiro</creatorcontrib><creatorcontrib>Hatsugai, Moriaki</creatorcontrib><creatorcontrib>Nakahara, Kazunari</creatorcontrib><creatorcontrib>Okamoto, Masaru</creatorcontrib><creatorcontrib>Kobayashi, Minoru</creatorcontrib><creatorcontrib>Ikeda, Hiroki</creatorcontrib><creatorcontrib>Fukuda, Yasunobu</creatorcontrib><creatorcontrib>Nagase, Yoshihiko</creatorcontrib><creatorcontrib>Ishii, Toshiya</creatorcontrib><creatorcontrib>Matsunaga, Kotaro</creatorcontrib><creatorcontrib>Matsumoto, Nobuyuki</creatorcontrib><creatorcontrib>Okuse, Chiaki</creatorcontrib><creatorcontrib>Sase, Shigeru</creatorcontrib><creatorcontrib>Itoh, Fumio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takahashi, Hideaki</au><au>Suzuki, Michihiro</au><au>Shigefuku, Ryuta</au><au>Okano, Miki</au><au>Hiraishi, Tetsuya</au><au>Takagi, Rei</au><au>Noguchi, Yohei</au><au>Hattori, Nobuhiro</au><au>Hatsugai, Moriaki</au><au>Nakahara, Kazunari</au><au>Okamoto, Masaru</au><au>Kobayashi, Minoru</au><au>Ikeda, Hiroki</au><au>Fukuda, Yasunobu</au><au>Nagase, Yoshihiko</au><au>Ishii, Toshiya</au><au>Matsunaga, Kotaro</au><au>Matsumoto, Nobuyuki</au><au>Okuse, Chiaki</au><au>Sase, Shigeru</au><au>Itoh, Fumio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Xenon computed tomography can evaluate the improvement of hepatic hemodynamics before and after endoscopic injection sclerotherapy</atitle><jtitle>Journal of gastroenterology</jtitle><stitle>J Gastroenterol</stitle><addtitle>J Gastroenterol</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>48</volume><issue>12</issue><spage>1353</spage><epage>1361</epage><pages>1353-1361</pages><issn>0944-1174</issn><eissn>1435-5922</eissn><abstract>Background
Xenon computed tomography (Xe-CT) provides quantitative information on tissue blood flow (TBF). In the present study, Xe-CT was performed in patients with esophagogastric varices (EGV) before and after endoscopic injection sclerotherapy (EIS) to evaluate hepatic blood flow (HBF), hepatic arterial TBF (HATBF) and portal venous TBF (PVTBF).
Methods
Subjects comprised of 88 patients with EGV (49 men, 39 women, average age 65.8 ± 11.5 years, median age 68 years, 30–86 years) and liver cirrhosis related to either hepatitis C virus (C) (
n
= 33), hepatitis B virus (B) (
n
= 3), alcohol (AL) (
n
= 22), AL + C (
n
= 7), AL + B (
n
= 1), B + C + AL (
n
= 1), nonalcoholic steatohepatitis (NASH) (
n
= 4), autoimmune hepatitis (AIH) (
n
= 5), primary biliary cirrhosis (PBC) (
n
= 2), or cryptogenic (
n
= 10) were enrolled. All patients, who were enrolled in this study, were performed EIS for prophylaxis. Xe-CT and measurement of the retention rate of indocyanine green 15 min after administration (ICG R15) were performed before and after EIS. Total hepatic TBF (THTBF) and PVTBF/HATBF ratio (P/A) were also calculated.
Results
PVTBF, HATBF, THTBF, P/A and ICG R15 before EIS were 28.3 ± 8.91, 22.5 ± 14.4 and 50.8 ± 17.6 ml/100 ml/min, 1.62 ± 0.71 and 28.8 ± 12.7 %, respectively and those after EIS were 31.9 ± 10.0, 19.3 ± 11.6, and 51.2 ± 17.0 ml/100 ml/min, 1.92 ± 0.84 and 23.6 ± 11.3 %, respectively. PVTBF and P/A after EIS were significantly higher than those before EIS (
p
= 0.00444,
p
= 0.0179, respectively), and HATBF and ICG R15 after EIS were significantly lower than those before EIS (
p
= 0.00129,
p
< 0.001, respectively).
Conclusions
Xenon computed tomography showed that PVTBF increased after EIS for EGV and HATBF decreased in response to an increase in PVTBF.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>23397117</pmid><doi>10.1007/s00535-013-0756-7</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-1174 |
| ispartof | Journal of gastroenterology, 2013-12, Vol.48 (12), p.1353-1361 |
| issn | 0944-1174 1435-5922 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1469646208 |
| source | MEDLINE; Springer Online Journals Complete |
| subjects | Abdominal Surgery Adult Aged Aged, 80 and over Biliary Tract Colorectal Surgery CT imaging Endoscopy - methods Esophageal and Gastric Varices - pathology Esophageal and Gastric Varices - therapy Female Gastroenterology Hepatic Artery - metabolism Hepatitis B Hepatitis C virus Hepatology Humans Liver Liver - blood supply Liver - pathology Liver cirrhosis Liver Cirrhosis - etiology Liver Cirrhosis - pathology Male Medicine Medicine & Public Health Middle Aged Original Article—Liver Pancreas Portal Vein - metabolism Prospective Studies Regional Blood Flow Sclerotherapy - methods Surgical Oncology Tomography, X-Ray Computed - methods Xenon |
| title | Xenon computed tomography can evaluate the improvement of hepatic hemodynamics before and after endoscopic injection sclerotherapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T01%3A24%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Xenon%20computed%20tomography%20can%20evaluate%20the%20improvement%20of%20hepatic%20hemodynamics%20before%20and%20after%20endoscopic%20injection%20sclerotherapy&rft.jtitle=Journal%20of%20gastroenterology&rft.au=Takahashi,%20Hideaki&rft.date=2013-12-01&rft.volume=48&rft.issue=12&rft.spage=1353&rft.epage=1361&rft.pages=1353-1361&rft.issn=0944-1174&rft.eissn=1435-5922&rft_id=info:doi/10.1007/s00535-013-0756-7&rft_dat=%3Cgale_proqu%3EA714584173%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1468810164&rft_id=info:pmid/23397117&rft_galeid=A714584173&rfr_iscdi=true |