Whole-blood gene expression profiling in ankylosing spondylitis identifies novel candidate genes that may contribute to the inflammatory and tissue-destructive disease aspects

•11 Genes had a close relationship with AS.•DEGs in conPPI are related with immune response.•Most genes in the 2 modules exist in cell receptor signaling pathway.•Most genes in the 2 modules exist in natural killer cell mediated cytotoxicity.•Most genes in the 2 modules exist in primary immunodefici...

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Veröffentlicht in:	Cellular immunology 2013-11, Vol.286 (1-2), p.59-64
Hauptverfasser:	Chen, Kai, Wei, Xian-Zhao, Zhu, Xiao-Dong, Bai, Yu-Shu, Chen, Yu, Wang, Chuan-Feng, Chen, Zi-Qiang, Li, Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Ankylosing spondylitis Coexpression network Cytotoxicity, Immunologic - genetics Differentially expressed genes Female Gene Expression Profiling Gene Expression Regulation Gene Regulatory Networks - immunology Humans Male Molecular Sequence Annotation Multigene Family Oligonucleotide Array Sequence Analysis Signal Transduction Spondylitis, Ankylosing - blood Spondylitis, Ankylosing - genetics Spondylitis, Ankylosing - immunology Spondylitis, Ankylosing - pathology
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