Effect of Two Lipid Emulsions on Reversing High-Dose Levobupivacaine-Induced Reduced Vasoconstriction in the Rat Aortas

The goals of this study were to determine which lipid emulsion (Intralipid ® and Lipofundin MCT/LCT ® ) is more effective in reversing high-dose levobupivacaine-induced reduced vasoconstriction in isolated rat aortas and to examine the associated cellular mechanisms with a particular focus on the en...

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Veröffentlicht in:	Cardiovascular toxicology 2013-12, Vol.13 (4), p.370-380
Hauptverfasser:	Ok, Seong-Ho, Park, Chang-Shin, Kim, Hye Jung, Lee, Soo Hee, Choi, Bo-Hwa, Eun, So Young, Kim, Kyung-Nam, Yang, Seong Min, Shin, Il-Woo, Choi, Mun-Jeoung, Sohn, Ju-Tae
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesiology Animals Aorta Aorta, Thoracic - drug effects Aorta, Thoracic - physiology Biological and medical sciences Biomedical and Life Sciences Biomedicine Blood vessels Bupivacaine Bupivacaine - administration & dosage Bupivacaine - analogs & derivatives Cardiology Coronary vessels Dilatation Dosage and administration Drug Combinations Drug dosages Drug toxicity and drugs side effects treatment Emulsions - administration & dosage Endothelium Ethylenediaminetetraacetic acid Fat Emulsions, Intravenous - administration & dosage Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - physiology Humans Laboratory animals Lipids Male Medical colleges Medical sciences Medicine Nitric oxide Organ Culture Techniques Oxidation Pharmacology. Drug treatments Pharmacology/Toxicology Phospholipids - administration & dosage Phosphorylation Rats Rats, Sprague-Dawley Sorbitol - administration & dosage Soybean Oil - administration & dosage Toxicity Toxicity: cardiovascular system Treatment Outcome Triglycerides Vasoconstriction Vasoconstriction - drug effects Vasoconstriction - physiology
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