Maternal Factor V Leiden and Prothrombin Mutations Do Not Seem to Contribute to the Occurrence of Two or More Than Two Consecutive Miscarriages in Caucasian patients
Background We analysed the prevalence of the most common hereditary thrombophilia (hTP) – factor V Leiden (FVL) mutation, prothrombin 20210 G>A substitution (PT) – and the 677 C>T replacement in the 5,10‐methylenetetrahydrofolate reductase (MTHFR) gene in Caucasian patients with a history of t...
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| Veröffentlicht in: | American journal of reproductive immunology (1989) 2013-12, Vol.70 (6), p.518-521 |
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| container_title | American journal of reproductive immunology (1989) |
| container_volume | 70 |
| creator | Baumann, Kristin Beuter-Winkler, Petra Hackethal, Andreas Strowitzki, Thomas Toth, Bettina Bohlmann, Michael K. |
| description | Background
We analysed the prevalence of the most common hereditary thrombophilia (hTP) – factor V Leiden (FVL) mutation, prothrombin 20210 G>A substitution (PT) – and the 677 C>T replacement in the 5,10‐methylenetetrahydrofolate reductase (MTHFR) gene in Caucasian patients with a history of two and more consecutive recurrent miscarriages (RMs) as compared to healthy controls with an identical ethnic background and at least one live birth.
Methods
A multicenter analysis of three hTP was performed in 641 RM patients identically screened at specialized university centres.
Results
The study groups consisted of 240 patients with 2 (1) and 401 patients with >2 miscarriages (2) and were compared with 157 controls. There was no significant difference in the prevalence of the hTP between RM patients and controls nor within the two study groups. Subgroup analysis showed that the homozygous MTHFR polymorphism was significantly more prevalent in the study group 2 as compared to study group 1 (13.9 versus 7.9%, P = 0.02).
Conclusion
In Caucasians, maternal FVL or PT mutations do not seem to contribute to the pathophysiology of RM, irrespective of the number of miscarriages. However, the role of the homozygous MTHFR polymorphism merits further investigation. |
| doi_str_mv | 10.1111/aji.12144 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1468382587</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1459563410</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4244-b737c0883463e4feddb1c3e029d16bea342e3943078272d5c84bd76ed798fa763</originalsourceid><addsrcrecordid>eNqNkcFu1DAQhiMEoqVw4AWQJS70kNaOHds5lqUtRZstiIVysxxnlvU2iRfbofSBeE-8u20PSEj4Ys_o-_-x5s-ylwQfkXSO9coekYIw9ijbJxzjHMtKPE5vzHguGJZ72bMQVhinPhVPs72CiqqUhO9nv2sdwQ-6Q2faROfRVzQF28KA9NCij97FpXd9YwdUj1FH64aA3jk0cxF9BuhRdGjihuhtM0bYVHEJ6NKY0XsYDCC3QPMbh5Jx7Tyg-VIP20YSBTBjtD8B1TYY7b3V3yGgNGmiR6ODTeQ6TYQhhufZk4XuAry4uw-yL2en88n7fHp5fjE5meaGFYzljaDCYCkp4xTYAtq2IYYCLqqW8AY0ZQXQilEsZCGKtjSSNa3g0IpKLrTg9CB7s_Nde_djhBBVn_4GXacHcGNQhHFJZVFK8R9oWZWcMoIT-vovdOXGzc63lGRFVRUsUYc7yngXgoeFWnvba3-rCFabmFWKWW1jTuyrO8ex6aF9IO9zTcDxDrixHdz-20mdfLi4t8x3Chsi_HpQaH-teFprqa5m5-qK12_lp9lUfaN_AAgbwI0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1458429924</pqid></control><display><type>article</type><title>Maternal Factor V Leiden and Prothrombin Mutations Do Not Seem to Contribute to the Occurrence of Two or More Than Two Consecutive Miscarriages in Caucasian patients</title><source>Wiley-Blackwell Journals</source><source>MEDLINE</source><creator>Baumann, Kristin ; Beuter-Winkler, Petra ; Hackethal, Andreas ; Strowitzki, Thomas ; Toth, Bettina ; Bohlmann, Michael K.</creator><creatorcontrib>Baumann, Kristin ; Beuter-Winkler, Petra ; Hackethal, Andreas ; Strowitzki, Thomas ; Toth, Bettina ; Bohlmann, Michael K.</creatorcontrib><description>Background
We analysed the prevalence of the most common hereditary thrombophilia (hTP) – factor V Leiden (FVL) mutation, prothrombin 20210 G>A substitution (PT) – and the 677 C>T replacement in the 5,10‐methylenetetrahydrofolate reductase (MTHFR) gene in Caucasian patients with a history of two and more consecutive recurrent miscarriages (RMs) as compared to healthy controls with an identical ethnic background and at least one live birth.
Methods
A multicenter analysis of three hTP was performed in 641 RM patients identically screened at specialized university centres.
Results
The study groups consisted of 240 patients with 2 (1) and 401 patients with >2 miscarriages (2) and were compared with 157 controls. There was no significant difference in the prevalence of the hTP between RM patients and controls nor within the two study groups. Subgroup analysis showed that the homozygous MTHFR polymorphism was significantly more prevalent in the study group 2 as compared to study group 1 (13.9 versus 7.9%, P = 0.02).
Conclusion
In Caucasians, maternal FVL or PT mutations do not seem to contribute to the pathophysiology of RM, irrespective of the number of miscarriages. However, the role of the homozygous MTHFR polymorphism merits further investigation.</description><identifier>ISSN: 1046-7408</identifier><identifier>EISSN: 1600-0897</identifier><identifier>DOI: 10.1111/aji.12144</identifier><identifier>PMID: 23795816</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Abortion, Habitual - enzymology ; Abortion, Habitual - genetics ; Adult ; Cohort Studies ; European Continental Ancestry Group - genetics ; Factor V - genetics ; Factor V Leiden mutation ; Female ; Humans ; Methylenetetrahydrofolate Reductase (NADPH2) - genetics ; MTHFR (C677T) polymorphism ; Mutation ; Polymorphism, Genetic - genetics ; prothrombin (G20210A) mutation ; Prothrombin - genetics ; recurrent miscarriage ; Retrospective Studies ; thrombophilia</subject><ispartof>American journal of reproductive immunology (1989), 2013-12, Vol.70 (6), p.518-521</ispartof><rights>2013 John Wiley & Sons Ltd</rights><rights>2013 John Wiley & Sons Ltd.</rights><rights>Copyright © 2013 John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4244-b737c0883463e4feddb1c3e029d16bea342e3943078272d5c84bd76ed798fa763</citedby><cites>FETCH-LOGICAL-c4244-b737c0883463e4feddb1c3e029d16bea342e3943078272d5c84bd76ed798fa763</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Faji.12144$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Faji.12144$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23795816$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Baumann, Kristin</creatorcontrib><creatorcontrib>Beuter-Winkler, Petra</creatorcontrib><creatorcontrib>Hackethal, Andreas</creatorcontrib><creatorcontrib>Strowitzki, Thomas</creatorcontrib><creatorcontrib>Toth, Bettina</creatorcontrib><creatorcontrib>Bohlmann, Michael K.</creatorcontrib><title>Maternal Factor V Leiden and Prothrombin Mutations Do Not Seem to Contribute to the Occurrence of Two or More Than Two Consecutive Miscarriages in Caucasian patients</title><title>American journal of reproductive immunology (1989)</title><addtitle>Am J Reprod Immunol</addtitle><description>Background
We analysed the prevalence of the most common hereditary thrombophilia (hTP) – factor V Leiden (FVL) mutation, prothrombin 20210 G>A substitution (PT) – and the 677 C>T replacement in the 5,10‐methylenetetrahydrofolate reductase (MTHFR) gene in Caucasian patients with a history of two and more consecutive recurrent miscarriages (RMs) as compared to healthy controls with an identical ethnic background and at least one live birth.
Methods
A multicenter analysis of three hTP was performed in 641 RM patients identically screened at specialized university centres.
Results
The study groups consisted of 240 patients with 2 (1) and 401 patients with >2 miscarriages (2) and were compared with 157 controls. There was no significant difference in the prevalence of the hTP between RM patients and controls nor within the two study groups. Subgroup analysis showed that the homozygous MTHFR polymorphism was significantly more prevalent in the study group 2 as compared to study group 1 (13.9 versus 7.9%, P = 0.02).
Conclusion
In Caucasians, maternal FVL or PT mutations do not seem to contribute to the pathophysiology of RM, irrespective of the number of miscarriages. However, the role of the homozygous MTHFR polymorphism merits further investigation.</description><subject>Abortion, Habitual - enzymology</subject><subject>Abortion, Habitual - genetics</subject><subject>Adult</subject><subject>Cohort Studies</subject><subject>European Continental Ancestry Group - genetics</subject><subject>Factor V - genetics</subject><subject>Factor V Leiden mutation</subject><subject>Female</subject><subject>Humans</subject><subject>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</subject><subject>MTHFR (C677T) polymorphism</subject><subject>Mutation</subject><subject>Polymorphism, Genetic - genetics</subject><subject>prothrombin (G20210A) mutation</subject><subject>Prothrombin - genetics</subject><subject>recurrent miscarriage</subject><subject>Retrospective Studies</subject><subject>thrombophilia</subject><issn>1046-7408</issn><issn>1600-0897</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcFu1DAQhiMEoqVw4AWQJS70kNaOHds5lqUtRZstiIVysxxnlvU2iRfbofSBeE-8u20PSEj4Ys_o-_-x5s-ylwQfkXSO9coekYIw9ijbJxzjHMtKPE5vzHguGJZ72bMQVhinPhVPs72CiqqUhO9nv2sdwQ-6Q2faROfRVzQF28KA9NCij97FpXd9YwdUj1FH64aA3jk0cxF9BuhRdGjihuhtM0bYVHEJ6NKY0XsYDCC3QPMbh5Jx7Tyg-VIP20YSBTBjtD8B1TYY7b3V3yGgNGmiR6ODTeQ6TYQhhufZk4XuAry4uw-yL2en88n7fHp5fjE5meaGFYzljaDCYCkp4xTYAtq2IYYCLqqW8AY0ZQXQilEsZCGKtjSSNa3g0IpKLrTg9CB7s_Nde_djhBBVn_4GXacHcGNQhHFJZVFK8R9oWZWcMoIT-vovdOXGzc63lGRFVRUsUYc7yngXgoeFWnvba3-rCFabmFWKWW1jTuyrO8ex6aF9IO9zTcDxDrixHdz-20mdfLi4t8x3Chsi_HpQaH-teFprqa5m5-qK12_lp9lUfaN_AAgbwI0</recordid><startdate>201312</startdate><enddate>201312</enddate><creator>Baumann, Kristin</creator><creator>Beuter-Winkler, Petra</creator><creator>Hackethal, Andreas</creator><creator>Strowitzki, Thomas</creator><creator>Toth, Bettina</creator><creator>Bohlmann, Michael K.</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201312</creationdate><title>Maternal Factor V Leiden and Prothrombin Mutations Do Not Seem to Contribute to the Occurrence of Two or More Than Two Consecutive Miscarriages in Caucasian patients</title><author>Baumann, Kristin ; Beuter-Winkler, Petra ; Hackethal, Andreas ; Strowitzki, Thomas ; Toth, Bettina ; Bohlmann, Michael K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4244-b737c0883463e4feddb1c3e029d16bea342e3943078272d5c84bd76ed798fa763</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Abortion, Habitual - enzymology</topic><topic>Abortion, Habitual - genetics</topic><topic>Adult</topic><topic>Cohort Studies</topic><topic>European Continental Ancestry Group - genetics</topic><topic>Factor V - genetics</topic><topic>Factor V Leiden mutation</topic><topic>Female</topic><topic>Humans</topic><topic>Methylenetetrahydrofolate Reductase (NADPH2) - genetics</topic><topic>MTHFR (C677T) polymorphism</topic><topic>Mutation</topic><topic>Polymorphism, Genetic - genetics</topic><topic>prothrombin (G20210A) mutation</topic><topic>Prothrombin - genetics</topic><topic>recurrent miscarriage</topic><topic>Retrospective Studies</topic><topic>thrombophilia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Baumann, Kristin</creatorcontrib><creatorcontrib>Beuter-Winkler, Petra</creatorcontrib><creatorcontrib>Hackethal, Andreas</creatorcontrib><creatorcontrib>Strowitzki, Thomas</creatorcontrib><creatorcontrib>Toth, Bettina</creatorcontrib><creatorcontrib>Bohlmann, Michael K.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Baumann, Kristin</au><au>Beuter-Winkler, Petra</au><au>Hackethal, Andreas</au><au>Strowitzki, Thomas</au><au>Toth, Bettina</au><au>Bohlmann, Michael K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Maternal Factor V Leiden and Prothrombin Mutations Do Not Seem to Contribute to the Occurrence of Two or More Than Two Consecutive Miscarriages in Caucasian patients</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>2013-12</date><risdate>2013</risdate><volume>70</volume><issue>6</issue><spage>518</spage><epage>521</epage><pages>518-521</pages><issn>1046-7408</issn><eissn>1600-0897</eissn><abstract>Background
We analysed the prevalence of the most common hereditary thrombophilia (hTP) – factor V Leiden (FVL) mutation, prothrombin 20210 G>A substitution (PT) – and the 677 C>T replacement in the 5,10‐methylenetetrahydrofolate reductase (MTHFR) gene in Caucasian patients with a history of two and more consecutive recurrent miscarriages (RMs) as compared to healthy controls with an identical ethnic background and at least one live birth.
Methods
A multicenter analysis of three hTP was performed in 641 RM patients identically screened at specialized university centres.
Results
The study groups consisted of 240 patients with 2 (1) and 401 patients with >2 miscarriages (2) and were compared with 157 controls. There was no significant difference in the prevalence of the hTP between RM patients and controls nor within the two study groups. Subgroup analysis showed that the homozygous MTHFR polymorphism was significantly more prevalent in the study group 2 as compared to study group 1 (13.9 versus 7.9%, P = 0.02).
Conclusion
In Caucasians, maternal FVL or PT mutations do not seem to contribute to the pathophysiology of RM, irrespective of the number of miscarriages. However, the role of the homozygous MTHFR polymorphism merits further investigation.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>23795816</pmid><doi>10.1111/aji.12144</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | American journal of reproductive immunology (1989), 2013-12, Vol.70 (6), p.518-521 |
| issn | 1046-7408 1600-0897 |
| language | eng |
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| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Abortion, Habitual - enzymology Abortion, Habitual - genetics Adult Cohort Studies European Continental Ancestry Group - genetics Factor V - genetics Factor V Leiden mutation Female Humans Methylenetetrahydrofolate Reductase (NADPH2) - genetics MTHFR (C677T) polymorphism Mutation Polymorphism, Genetic - genetics prothrombin (G20210A) mutation Prothrombin - genetics recurrent miscarriage Retrospective Studies thrombophilia |
| title | Maternal Factor V Leiden and Prothrombin Mutations Do Not Seem to Contribute to the Occurrence of Two or More Than Two Consecutive Miscarriages in Caucasian patients |
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