Bacteriological pathogen spectrum of chronic leg ulcers: Results of a multicenter trial in dermatologic wound care centers differentiated by regions
Summary Background In almost every chronic wound different bacteria species can be detected. Patients and methods Retrospective, multicenter evaluation of bacterial swab results from 2010 and 2011 in patients with chronic leg ulcer treated in 10 dermatologic wound care centers from 5 regions in Germ...
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| Veröffentlicht in: | Journal der Deutschen Dermatologischen Gesellschaft 2013-11, Vol.11 (11), p.1057-1063 |
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| container_title | Journal der Deutschen Dermatologischen Gesellschaft |
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| creator | Jockenhöfer, Finja Gollnick, Harald Herberger, Katharina Isbary, Georg Renner, Regina Stücker, Markus Valesky, Eva Wollina, Uwe Weichenthal, Michael Karrer, Sigrid Klode, Joachim Dissemond, Joachim |
| description | Summary
Background
In almost every chronic wound different bacteria species can be detected.
Patients and methods
Retrospective, multicenter evaluation of bacterial swab results from 2010 and 2011 in patients with chronic leg ulcer treated in 10 dermatologic wound care centers from 5 regions in Germany.
Results
Data of 970 patients were analyzed. Staphylococcus aureus was detected in 47.6 % of the patients, 8.6% of these were methicillin‐resistant (MRSA). Pseudomonas aeruginosa was found in 31.1 %, enterobacteria in 28.6 % and Proteus mirabilis in 13.7 % of the patients. The regional comparison showed a significant south‐north gradient for S. aureus, P. aeruginosa, and enterobacteria. Moreover, a highly significant west‐east gradient for MRSA was found with detection rates of 13.5 % in the west to 4.0 % in the east. Furthermore, nationally there was a significant negative correlation between S. aureus and P. aeruginosa or P. mirabilis, respectively, as well as a positive correlation of P. aeruginosa with respect to wound size and duration. In addition to climatic and therapeutic conditions, different regional health care structures are discussed as potentially relevant reasons for these significantly different regional detection rates.
Conclusions
Our data show the regional variability of the spectrum of currently detected bacteria in patients with chronic leg ulcers in Germany. |
| doi_str_mv | 10.1111/ddg.12170 |
| format | Article |
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Background
In almost every chronic wound different bacteria species can be detected.
Patients and methods
Retrospective, multicenter evaluation of bacterial swab results from 2010 and 2011 in patients with chronic leg ulcer treated in 10 dermatologic wound care centers from 5 regions in Germany.
Results
Data of 970 patients were analyzed. Staphylococcus aureus was detected in 47.6 % of the patients, 8.6% of these were methicillin‐resistant (MRSA). Pseudomonas aeruginosa was found in 31.1 %, enterobacteria in 28.6 % and Proteus mirabilis in 13.7 % of the patients. The regional comparison showed a significant south‐north gradient for S. aureus, P. aeruginosa, and enterobacteria. Moreover, a highly significant west‐east gradient for MRSA was found with detection rates of 13.5 % in the west to 4.0 % in the east. Furthermore, nationally there was a significant negative correlation between S. aureus and P. aeruginosa or P. mirabilis, respectively, as well as a positive correlation of P. aeruginosa with respect to wound size and duration. In addition to climatic and therapeutic conditions, different regional health care structures are discussed as potentially relevant reasons for these significantly different regional detection rates.
Conclusions
Our data show the regional variability of the spectrum of currently detected bacteria in patients with chronic leg ulcers in Germany.</description><identifier>ISSN: 1610-0379</identifier><identifier>EISSN: 1610-0387</identifier><identifier>DOI: 10.1111/ddg.12170</identifier><identifier>PMID: 23945189</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Aged ; Bacteria - isolation & purification ; Chronic Disease ; Climate ; Clinical trials ; Female ; Germany - epidemiology ; Health Care Surveys ; Humans ; Leg Ulcer - epidemiology ; Leg Ulcer - microbiology ; Leg Ulcer - pathology ; Male ; Prevalence ; Proteus mirabilis ; Risk Factors ; Water Microbiology ; Wound Healing</subject><ispartof>Journal der Deutschen Dermatologischen Gesellschaft, 2013-11, Vol.11 (11), p.1057-1063</ispartof><rights>The Authors | Journal compilation © Blackwell Verlag GmbH, Berlin</rights><rights>The Authors | Journal compilation © Blackwell Verlag GmbH, Berlin.</rights><rights>Journal compilation © Blackwell Verlag GmbH, Berlin</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3390-68a2f012dcfece2d895c41f7e30fc0e3747aa4abafeba15ae4a107dd97f55623</citedby><cites>FETCH-LOGICAL-c3390-68a2f012dcfece2d895c41f7e30fc0e3747aa4abafeba15ae4a107dd97f55623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fddg.12170$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fddg.12170$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23945189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jockenhöfer, Finja</creatorcontrib><creatorcontrib>Gollnick, Harald</creatorcontrib><creatorcontrib>Herberger, Katharina</creatorcontrib><creatorcontrib>Isbary, Georg</creatorcontrib><creatorcontrib>Renner, Regina</creatorcontrib><creatorcontrib>Stücker, Markus</creatorcontrib><creatorcontrib>Valesky, Eva</creatorcontrib><creatorcontrib>Wollina, Uwe</creatorcontrib><creatorcontrib>Weichenthal, Michael</creatorcontrib><creatorcontrib>Karrer, Sigrid</creatorcontrib><creatorcontrib>Klode, Joachim</creatorcontrib><creatorcontrib>Dissemond, Joachim</creatorcontrib><title>Bacteriological pathogen spectrum of chronic leg ulcers: Results of a multicenter trial in dermatologic wound care centers differentiated by regions</title><title>Journal der Deutschen Dermatologischen Gesellschaft</title><addtitle>JDDG: Journal der Deutschen Dermatologischen Gesellschaft</addtitle><description>Summary
Background
In almost every chronic wound different bacteria species can be detected.
Patients and methods
Retrospective, multicenter evaluation of bacterial swab results from 2010 and 2011 in patients with chronic leg ulcer treated in 10 dermatologic wound care centers from 5 regions in Germany.
Results
Data of 970 patients were analyzed. Staphylococcus aureus was detected in 47.6 % of the patients, 8.6% of these were methicillin‐resistant (MRSA). Pseudomonas aeruginosa was found in 31.1 %, enterobacteria in 28.6 % and Proteus mirabilis in 13.7 % of the patients. The regional comparison showed a significant south‐north gradient for S. aureus, P. aeruginosa, and enterobacteria. Moreover, a highly significant west‐east gradient for MRSA was found with detection rates of 13.5 % in the west to 4.0 % in the east. Furthermore, nationally there was a significant negative correlation between S. aureus and P. aeruginosa or P. mirabilis, respectively, as well as a positive correlation of P. aeruginosa with respect to wound size and duration. In addition to climatic and therapeutic conditions, different regional health care structures are discussed as potentially relevant reasons for these significantly different regional detection rates.
Conclusions
Our data show the regional variability of the spectrum of currently detected bacteria in patients with chronic leg ulcers in Germany.</description><subject>Aged</subject><subject>Bacteria - isolation & purification</subject><subject>Chronic Disease</subject><subject>Climate</subject><subject>Clinical trials</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Health Care Surveys</subject><subject>Humans</subject><subject>Leg Ulcer - epidemiology</subject><subject>Leg Ulcer - microbiology</subject><subject>Leg Ulcer - pathology</subject><subject>Male</subject><subject>Prevalence</subject><subject>Proteus mirabilis</subject><subject>Risk Factors</subject><subject>Water Microbiology</subject><subject>Wound Healing</subject><issn>1610-0379</issn><issn>1610-0387</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUFvFCEYhonR2Hb14B8wJF70MC0MzDDjzba6a1I1MZt4JCx8TKnMsIWZ1P0f_cGyTrsHExO58BKe70ngRegVJac0rzNjulNaUkGeoGNaU1IQ1oinhyzaI3SS0g0hZdUQ8hwdlazlFW3aY3R_rvQI0QUfOqeVx1s1XocOBpy2oMc49ThYrK9jGJzGHjo8eQ0xvcffIU1-TPtrhfscnYYhq_AYXfa4ARuIvRpnM74L02CwVhHwzCVsnLUQ88GpEQze7HCEzoUhvUDPrPIJXj7sC7T-9HF9sSquvi0_X3y4KjRjLSnqRpWW0NJoCxpK07SV5tQKYMRqAkxwoRRXG2Vho2ilgCtKhDGtsFVVl2yB3s7abQy3E6RR9i5p8F4NEKYkKa-b_Hk1of-BcsZJzekeffMXehOmOOR37Cla85Jm7QK9mykdQ0oRrNxG16u4k5TIfakylyr_lJrZ1w_GadODOZCPLWbgbAbunIfdv03y8nL5qCzmCZdG-HWYUPGnrAUTlfzxdSm_MHG-XtWrHH4DW3u89w</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Jockenhöfer, Finja</creator><creator>Gollnick, Harald</creator><creator>Herberger, Katharina</creator><creator>Isbary, Georg</creator><creator>Renner, Regina</creator><creator>Stücker, Markus</creator><creator>Valesky, Eva</creator><creator>Wollina, Uwe</creator><creator>Weichenthal, Michael</creator><creator>Karrer, Sigrid</creator><creator>Klode, Joachim</creator><creator>Dissemond, Joachim</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>201311</creationdate><title>Bacteriological pathogen spectrum of chronic leg ulcers: Results of a multicenter trial in dermatologic wound care centers differentiated by regions</title><author>Jockenhöfer, Finja ; Gollnick, Harald ; Herberger, Katharina ; Isbary, Georg ; Renner, Regina ; Stücker, Markus ; Valesky, Eva ; Wollina, Uwe ; Weichenthal, Michael ; Karrer, Sigrid ; Klode, Joachim ; Dissemond, Joachim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3390-68a2f012dcfece2d895c41f7e30fc0e3747aa4abafeba15ae4a107dd97f55623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Bacteria - isolation & purification</topic><topic>Chronic Disease</topic><topic>Climate</topic><topic>Clinical trials</topic><topic>Female</topic><topic>Germany - epidemiology</topic><topic>Health Care Surveys</topic><topic>Humans</topic><topic>Leg Ulcer - epidemiology</topic><topic>Leg Ulcer - microbiology</topic><topic>Leg Ulcer - pathology</topic><topic>Male</topic><topic>Prevalence</topic><topic>Proteus mirabilis</topic><topic>Risk Factors</topic><topic>Water Microbiology</topic><topic>Wound Healing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jockenhöfer, Finja</creatorcontrib><creatorcontrib>Gollnick, Harald</creatorcontrib><creatorcontrib>Herberger, Katharina</creatorcontrib><creatorcontrib>Isbary, Georg</creatorcontrib><creatorcontrib>Renner, Regina</creatorcontrib><creatorcontrib>Stücker, Markus</creatorcontrib><creatorcontrib>Valesky, Eva</creatorcontrib><creatorcontrib>Wollina, Uwe</creatorcontrib><creatorcontrib>Weichenthal, Michael</creatorcontrib><creatorcontrib>Karrer, Sigrid</creatorcontrib><creatorcontrib>Klode, Joachim</creatorcontrib><creatorcontrib>Dissemond, Joachim</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal der Deutschen Dermatologischen Gesellschaft</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jockenhöfer, Finja</au><au>Gollnick, Harald</au><au>Herberger, Katharina</au><au>Isbary, Georg</au><au>Renner, Regina</au><au>Stücker, Markus</au><au>Valesky, Eva</au><au>Wollina, Uwe</au><au>Weichenthal, Michael</au><au>Karrer, Sigrid</au><au>Klode, Joachim</au><au>Dissemond, Joachim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bacteriological pathogen spectrum of chronic leg ulcers: Results of a multicenter trial in dermatologic wound care centers differentiated by regions</atitle><jtitle>Journal der Deutschen Dermatologischen Gesellschaft</jtitle><addtitle>JDDG: Journal der Deutschen Dermatologischen Gesellschaft</addtitle><date>2013-11</date><risdate>2013</risdate><volume>11</volume><issue>11</issue><spage>1057</spage><epage>1063</epage><pages>1057-1063</pages><issn>1610-0379</issn><eissn>1610-0387</eissn><abstract>Summary
Background
In almost every chronic wound different bacteria species can be detected.
Patients and methods
Retrospective, multicenter evaluation of bacterial swab results from 2010 and 2011 in patients with chronic leg ulcer treated in 10 dermatologic wound care centers from 5 regions in Germany.
Results
Data of 970 patients were analyzed. Staphylococcus aureus was detected in 47.6 % of the patients, 8.6% of these were methicillin‐resistant (MRSA). Pseudomonas aeruginosa was found in 31.1 %, enterobacteria in 28.6 % and Proteus mirabilis in 13.7 % of the patients. The regional comparison showed a significant south‐north gradient for S. aureus, P. aeruginosa, and enterobacteria. Moreover, a highly significant west‐east gradient for MRSA was found with detection rates of 13.5 % in the west to 4.0 % in the east. Furthermore, nationally there was a significant negative correlation between S. aureus and P. aeruginosa or P. mirabilis, respectively, as well as a positive correlation of P. aeruginosa with respect to wound size and duration. In addition to climatic and therapeutic conditions, different regional health care structures are discussed as potentially relevant reasons for these significantly different regional detection rates.
Conclusions
Our data show the regional variability of the spectrum of currently detected bacteria in patients with chronic leg ulcers in Germany.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>23945189</pmid><doi>10.1111/ddg.12170</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Bacteria - isolation & purification Chronic Disease Climate Clinical trials Female Germany - epidemiology Health Care Surveys Humans Leg Ulcer - epidemiology Leg Ulcer - microbiology Leg Ulcer - pathology Male Prevalence Proteus mirabilis Risk Factors Water Microbiology Wound Healing |
| title | Bacteriological pathogen spectrum of chronic leg ulcers: Results of a multicenter trial in dermatologic wound care centers differentiated by regions |
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