New insights into the influence of cigarette smoking on urothelial carcinogenesis: Smoking-induced gene expression in tumor-free urothelium might discriminate muscle-invasive from nonmuscle-invasive urothelial bladder cancer
Smoking is the main risk factor for urothelial bladder cancer. In former smokers the risk decreases but does not reach the low level of never smokers. This indicates reversible and permanent smoking‐derived genetic alterations. Transcriptional changes may point to mechanisms, how smoking promotes ur...
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| Veröffentlicht in: | Molecular carcinogenesis 2012-11, Vol.51 (11), p.907-915 |
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| container_title | Molecular carcinogenesis |
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| creator | Gabriel, Ute Li, Li Bolenz, Christian Steidler, Annette Kränzlin, Bettina Saile, Maria Gretz, Norbert Trojan, Lutz Michel, Maurice Stephan |
| description | Smoking is the main risk factor for urothelial bladder cancer. In former smokers the risk decreases but does not reach the low level of never smokers. This indicates reversible and permanent smoking‐derived genetic alterations. Transcriptional changes may point to mechanisms, how smoking promotes urothelial bladder cancer. To identify smoking‐derived transcriptional changes we performed gene expression profiling in current, former, and never smokers, using tumor and tumor‐free urothelium from patients with nonmuscle‐invasive urothelial bladder cancer (NMIBC) or muscle‐invasive urothelial bladder cancer (MIBC). Smoking turned out to influence gene expression much less than tumor stage (NMIBC or MIBC) and tumor transformation (tumor‐free or tumor). Smoking seemed to influence gene expression in patients with MIBC more strongly compared to those with NMIBC. The least irreversible changes after smoking cessation were proposed in tumor‐free urothelium from patients with NMIBC. Growth factors and oncogenes were up‐regulated in tumor‐free urothelium from smokers with MIBC but not from smokers with NMIBC. A panel of genes up‐regulated in smokers have potential for early detection and distinction of MIBC from NMIBC using tumor‐free tissue. © 2011 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/mc.20860 |
| format | Article |
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In former smokers the risk decreases but does not reach the low level of never smokers. This indicates reversible and permanent smoking‐derived genetic alterations. Transcriptional changes may point to mechanisms, how smoking promotes urothelial bladder cancer. To identify smoking‐derived transcriptional changes we performed gene expression profiling in current, former, and never smokers, using tumor and tumor‐free urothelium from patients with nonmuscle‐invasive urothelial bladder cancer (NMIBC) or muscle‐invasive urothelial bladder cancer (MIBC). Smoking turned out to influence gene expression much less than tumor stage (NMIBC or MIBC) and tumor transformation (tumor‐free or tumor). Smoking seemed to influence gene expression in patients with MIBC more strongly compared to those with NMIBC. The least irreversible changes after smoking cessation were proposed in tumor‐free urothelium from patients with NMIBC. Growth factors and oncogenes were up‐regulated in tumor‐free urothelium from smokers with MIBC but not from smokers with NMIBC. A panel of genes up‐regulated in smokers have potential for early detection and distinction of MIBC from NMIBC using tumor‐free tissue. © 2011 Wiley Periodicals, Inc.</description><identifier>ISSN: 0899-1987</identifier><identifier>EISSN: 1098-2744</identifier><identifier>DOI: 10.1002/mc.20860</identifier><identifier>PMID: 21976419</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Bladder cancer ; Cancer ; Cell Transformation, Neoplastic - genetics ; Cell Transformation, Neoplastic - metabolism ; Cell Transformation, Neoplastic - pathology ; Disease Progression ; Gene expression ; Gene Expression Regulation ; Humans ; markers ; microarray analysis ; Neoplasm Invasiveness - genetics ; Neoplasm Invasiveness - pathology ; risk assessment ; Signal Transduction ; Smoking ; Smoking - adverse effects ; Smoking - genetics ; Smoking - metabolism ; Smoking - pathology ; Smoking Cessation ; tobacco smoking ; Tumors ; Urinary Bladder - metabolism ; Urinary Bladder - pathology ; Urinary Bladder Neoplasms - genetics ; Urinary Bladder Neoplasms - metabolism ; Urinary Bladder Neoplasms - pathology ; urothelial carcinoma ; Urothelium - metabolism ; Urothelium - pathology</subject><ispartof>Molecular carcinogenesis, 2012-11, Vol.51 (11), p.907-915</ispartof><rights>Copyright © 2011 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4200-83d16874450e9117c43b0878bd46efbef3d9f04e746daf1b8e988ee8593c16be3</citedby><cites>FETCH-LOGICAL-c4200-83d16874450e9117c43b0878bd46efbef3d9f04e746daf1b8e988ee8593c16be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmc.20860$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmc.20860$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21976419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gabriel, Ute</creatorcontrib><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Bolenz, Christian</creatorcontrib><creatorcontrib>Steidler, Annette</creatorcontrib><creatorcontrib>Kränzlin, Bettina</creatorcontrib><creatorcontrib>Saile, Maria</creatorcontrib><creatorcontrib>Gretz, Norbert</creatorcontrib><creatorcontrib>Trojan, Lutz</creatorcontrib><creatorcontrib>Michel, Maurice Stephan</creatorcontrib><title>New insights into the influence of cigarette smoking on urothelial carcinogenesis: Smoking-induced gene expression in tumor-free urothelium might discriminate muscle-invasive from nonmuscle-invasive urothelial bladder cancer</title><title>Molecular carcinogenesis</title><addtitle>Mol. Carcinog</addtitle><description>Smoking is the main risk factor for urothelial bladder cancer. In former smokers the risk decreases but does not reach the low level of never smokers. This indicates reversible and permanent smoking‐derived genetic alterations. Transcriptional changes may point to mechanisms, how smoking promotes urothelial bladder cancer. To identify smoking‐derived transcriptional changes we performed gene expression profiling in current, former, and never smokers, using tumor and tumor‐free urothelium from patients with nonmuscle‐invasive urothelial bladder cancer (NMIBC) or muscle‐invasive urothelial bladder cancer (MIBC). Smoking turned out to influence gene expression much less than tumor stage (NMIBC or MIBC) and tumor transformation (tumor‐free or tumor). Smoking seemed to influence gene expression in patients with MIBC more strongly compared to those with NMIBC. The least irreversible changes after smoking cessation were proposed in tumor‐free urothelium from patients with NMIBC. Growth factors and oncogenes were up‐regulated in tumor‐free urothelium from smokers with MIBC but not from smokers with NMIBC. A panel of genes up‐regulated in smokers have potential for early detection and distinction of MIBC from NMIBC using tumor‐free tissue. © 2011 Wiley Periodicals, Inc.</description><subject>Bladder cancer</subject><subject>Cancer</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Cell Transformation, Neoplastic - metabolism</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Disease Progression</subject><subject>Gene expression</subject><subject>Gene Expression Regulation</subject><subject>Humans</subject><subject>markers</subject><subject>microarray analysis</subject><subject>Neoplasm Invasiveness - genetics</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>risk assessment</subject><subject>Signal Transduction</subject><subject>Smoking</subject><subject>Smoking - adverse effects</subject><subject>Smoking - genetics</subject><subject>Smoking - metabolism</subject><subject>Smoking - pathology</subject><subject>Smoking Cessation</subject><subject>tobacco smoking</subject><subject>Tumors</subject><subject>Urinary Bladder - metabolism</subject><subject>Urinary Bladder - pathology</subject><subject>Urinary Bladder Neoplasms - genetics</subject><subject>Urinary Bladder Neoplasms - metabolism</subject><subject>Urinary Bladder Neoplasms - pathology</subject><subject>urothelial carcinoma</subject><subject>Urothelium - metabolism</subject><subject>Urothelium - pathology</subject><issn>0899-1987</issn><issn>1098-2744</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kd9uFCEYxYnR2LWa-ASGxBtvpsIMOwPe2VWrSV1j1PSSMPDNlnaAFYb-eVsfRdbdrqaJV3yBH4fDOQg9p-SIElK_dvqoJrwlD9CMEsGrumPsIZoRLkRFBe8O0JOULgihtJuTx-igpqJrGRUz9GsJ19j6ZFfnUyrDFPB0DmUYxgxeAw4D1nalIkwT4OTCpfUrHDzOMRRwtGrEWkVtfViBh2TTG_xtS1XWm6zB4M0Bhpt1hJRsuWo9nrILsRoiwF4oO-w2LrCxSUfrrFflRZeTHqFIXalkrwAPMTjsg7-__4-dflTGQCy2iv_4FD0a1Jjg2W49RD8-vP---Fidfjn5tHh7WmlWE1LxxtCWl9jmBESJSbOmJ7zjvWEtDD0MjREDYdCx1qiB9hwE5wB8LhpN2x6aQ_Rqq7uO4WeGNElX_gHjqDyEnCRlLW9K-l1T0Jf30IuQoy_uCsVKgXROxF9BHUNKEQa5LqmoeCspkZvWpdPyT-sFfbETzL0Dswfvai5AtQWu7Qi3_xWSnxd3gjvepglu9ryKl7Ltyi_k2fJE8iU5Pvv6TshF8xvRYctN</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Gabriel, Ute</creator><creator>Li, Li</creator><creator>Bolenz, Christian</creator><creator>Steidler, Annette</creator><creator>Kränzlin, Bettina</creator><creator>Saile, Maria</creator><creator>Gretz, Norbert</creator><creator>Trojan, Lutz</creator><creator>Michel, Maurice Stephan</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>201211</creationdate><title>New insights into the influence of cigarette smoking on urothelial carcinogenesis: Smoking-induced gene expression in tumor-free urothelium might discriminate muscle-invasive from nonmuscle-invasive urothelial bladder cancer</title><author>Gabriel, Ute ; Li, Li ; Bolenz, Christian ; Steidler, Annette ; Kränzlin, Bettina ; Saile, Maria ; Gretz, Norbert ; Trojan, Lutz ; Michel, Maurice Stephan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4200-83d16874450e9117c43b0878bd46efbef3d9f04e746daf1b8e988ee8593c16be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Bladder cancer</topic><topic>Cancer</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Cell Transformation, Neoplastic - metabolism</topic><topic>Cell Transformation, Neoplastic - pathology</topic><topic>Disease Progression</topic><topic>Gene expression</topic><topic>Gene Expression Regulation</topic><topic>Humans</topic><topic>markers</topic><topic>microarray analysis</topic><topic>Neoplasm Invasiveness - genetics</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>risk assessment</topic><topic>Signal Transduction</topic><topic>Smoking</topic><topic>Smoking - adverse effects</topic><topic>Smoking - genetics</topic><topic>Smoking - metabolism</topic><topic>Smoking - pathology</topic><topic>Smoking Cessation</topic><topic>tobacco smoking</topic><topic>Tumors</topic><topic>Urinary Bladder - metabolism</topic><topic>Urinary Bladder - pathology</topic><topic>Urinary Bladder Neoplasms - genetics</topic><topic>Urinary Bladder Neoplasms - metabolism</topic><topic>Urinary Bladder Neoplasms - pathology</topic><topic>urothelial carcinoma</topic><topic>Urothelium - metabolism</topic><topic>Urothelium - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gabriel, Ute</creatorcontrib><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Bolenz, Christian</creatorcontrib><creatorcontrib>Steidler, Annette</creatorcontrib><creatorcontrib>Kränzlin, Bettina</creatorcontrib><creatorcontrib>Saile, Maria</creatorcontrib><creatorcontrib>Gretz, Norbert</creatorcontrib><creatorcontrib>Trojan, Lutz</creatorcontrib><creatorcontrib>Michel, Maurice Stephan</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Molecular carcinogenesis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gabriel, Ute</au><au>Li, Li</au><au>Bolenz, Christian</au><au>Steidler, Annette</au><au>Kränzlin, Bettina</au><au>Saile, Maria</au><au>Gretz, Norbert</au><au>Trojan, Lutz</au><au>Michel, Maurice Stephan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New insights into the influence of cigarette smoking on urothelial carcinogenesis: Smoking-induced gene expression in tumor-free urothelium might discriminate muscle-invasive from nonmuscle-invasive urothelial bladder cancer</atitle><jtitle>Molecular carcinogenesis</jtitle><addtitle>Mol. Carcinog</addtitle><date>2012-11</date><risdate>2012</risdate><volume>51</volume><issue>11</issue><spage>907</spage><epage>915</epage><pages>907-915</pages><issn>0899-1987</issn><eissn>1098-2744</eissn><abstract>Smoking is the main risk factor for urothelial bladder cancer. In former smokers the risk decreases but does not reach the low level of never smokers. This indicates reversible and permanent smoking‐derived genetic alterations. Transcriptional changes may point to mechanisms, how smoking promotes urothelial bladder cancer. To identify smoking‐derived transcriptional changes we performed gene expression profiling in current, former, and never smokers, using tumor and tumor‐free urothelium from patients with nonmuscle‐invasive urothelial bladder cancer (NMIBC) or muscle‐invasive urothelial bladder cancer (MIBC). Smoking turned out to influence gene expression much less than tumor stage (NMIBC or MIBC) and tumor transformation (tumor‐free or tumor). Smoking seemed to influence gene expression in patients with MIBC more strongly compared to those with NMIBC. The least irreversible changes after smoking cessation were proposed in tumor‐free urothelium from patients with NMIBC. Growth factors and oncogenes were up‐regulated in tumor‐free urothelium from smokers with MIBC but not from smokers with NMIBC. A panel of genes up‐regulated in smokers have potential for early detection and distinction of MIBC from NMIBC using tumor‐free tissue. © 2011 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>21976419</pmid><doi>10.1002/mc.20860</doi><tpages>9</tpages></addata></record> |
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| ispartof | Molecular carcinogenesis, 2012-11, Vol.51 (11), p.907-915 |
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| subjects | Bladder cancer Cancer Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Cell Transformation, Neoplastic - pathology Disease Progression Gene expression Gene Expression Regulation Humans markers microarray analysis Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology risk assessment Signal Transduction Smoking Smoking - adverse effects Smoking - genetics Smoking - metabolism Smoking - pathology Smoking Cessation tobacco smoking Tumors Urinary Bladder - metabolism Urinary Bladder - pathology Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology urothelial carcinoma Urothelium - metabolism Urothelium - pathology |
| title | New insights into the influence of cigarette smoking on urothelial carcinogenesis: Smoking-induced gene expression in tumor-free urothelium might discriminate muscle-invasive from nonmuscle-invasive urothelial bladder cancer |
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