A two-step sulfation in antibiotic biosynthesis requires a type III polyketide synthase

Two families of sulfotransferases are known, but the natural sulfate source for the PAPS-independent enzymes was not clear. Investigation of the caprazamycin pathway reveals a type III PKS generates a chemical reagent that is sulfated by a PAPS-dependent sulfotransferase to generate the unknown sulf...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Nature chemical biology 2013-10, Vol.9 (10), p.610-615
Hauptverfasser:	Tang, Xiaoyu, Eitel, Kornelia, Kaysser, Leonard, Kulik, Andreas, Grond, Stephanie, Gust, Bertolt
Format:	Artikel
Sprache:	eng
Schlagworte:	631/326/41 631/92/173 631/92/60 631/92/96 Acyltransferases - classification Acyltransferases - metabolism Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemistry Antibiotics Biochemical Engineering Biochemistry Bioorganic Chemistry Biosynthesis Cell Biology Chemistry Chemistry/Food Science Enzymes Esters Molecular Structure Pharmacology Phenols Sulfates Sulfates - chemistry Sulfates - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!