Effector T-cell differentiation during viral and bacterial infections: Role of direct IL-12 signals for cell fate decision of CD8 super(+) T cells

To study the role of IL-12 as a third signal for T-cell activation and differentiation in vivo, direct IL-12 signaling to CD8 super(+) T cells was analyzed in bacterial and viral infections using the P14 T-cell adoptive transfer model with CD8 super(+) T cells that lack the IL-12 receptor. Results i...

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Veröffentlicht in:	European journal of immunology 2009-07, Vol.39 (7), p.1774-1783
Hauptverfasser:	Keppler, Selina J, Theil, Kerstin, Vucikuja, Smiljka, Aichele, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria Listeria monocytogenes Lymphocytic choriomeningitis virus Vaccinia virus Vesicular stomatitis virus
Online-Zugang:	Volltext
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