Protective effect of lycopene on oxidative stress and antioxidant status in Cyprinus carpio during cypermethrin exposure
The aim of this study was to investigate the ameliorative properties of lycopene against the toxic effects of cypermethrin (CYP) by examining oxidative damage markers such as lipid peroxidation and the antioxidant defense system components in carp (Cyprinus carpio). The fish were divided into seven...
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| Veröffentlicht in: | Environmental toxicology 2013-11, Vol.28 (11), p.609-616 |
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| description | The aim of this study was to investigate the ameliorative properties of lycopene against the toxic effects of cypermethrin (CYP) by examining oxidative damage markers such as lipid peroxidation and the antioxidant defense system components in carp (Cyprinus carpio). The fish were divided into seven groups of 10 fish each and received the following treatments: group 1, no treatment; group 2, orally administered corn oil; group 3, oral lycopene (10 mg/kg body weight); group 4, exposure to 0.202 μg/L CYP; group 5, exposure to 0.202 μg/L CYP plus oral administration of 10 mg/kg lycopene; group 6, exposure to 0.404 μg/L CYP; and group 7, exposure to 0.404 μg/L CYP plus oral administration of 10 mg/kg lycopene. Treatment was continued for 28 days, and at the end of this period, blood and tissue (liver, kidney, and gill) samples were collected. Levels of malondialdehyde (MDA) and reduced glutathione (GSH) as well as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH‐Px) activities were determined in blood and tissues for measurement of oxidant‐antioxidant status. MDA level, as an index of lipid peroxidation, increased in blood and tissues. Antioxidant enzyme activities in blood and tissues were modified in CYP groups compared with controls. Administration of lycopene ameliorated these parameters. The present results suggest that administration of lycopene might alleviate CYP‐induced oxidative stress. © 2011 Wiley Periodicals, Inc. Environ Toxicol 28:609–616, 2013. |
| doi_str_mv | 10.1002/tox.20757 |
| format | Article |
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Enis</creator><creatorcontrib>Yonar, M. Enis</creatorcontrib><description>The aim of this study was to investigate the ameliorative properties of lycopene against the toxic effects of cypermethrin (CYP) by examining oxidative damage markers such as lipid peroxidation and the antioxidant defense system components in carp (Cyprinus carpio). The fish were divided into seven groups of 10 fish each and received the following treatments: group 1, no treatment; group 2, orally administered corn oil; group 3, oral lycopene (10 mg/kg body weight); group 4, exposure to 0.202 μg/L CYP; group 5, exposure to 0.202 μg/L CYP plus oral administration of 10 mg/kg lycopene; group 6, exposure to 0.404 μg/L CYP; and group 7, exposure to 0.404 μg/L CYP plus oral administration of 10 mg/kg lycopene. Treatment was continued for 28 days, and at the end of this period, blood and tissue (liver, kidney, and gill) samples were collected. Levels of malondialdehyde (MDA) and reduced glutathione (GSH) as well as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH‐Px) activities were determined in blood and tissues for measurement of oxidant‐antioxidant status. MDA level, as an index of lipid peroxidation, increased in blood and tissues. Antioxidant enzyme activities in blood and tissues were modified in CYP groups compared with controls. Administration of lycopene ameliorated these parameters. The present results suggest that administration of lycopene might alleviate CYP‐induced oxidative stress. © 2011 Wiley Periodicals, Inc. Environ Toxicol 28:609–616, 2013.</description><identifier>ISSN: 1520-4081</identifier><identifier>EISSN: 1522-7278</identifier><identifier>DOI: 10.1002/tox.20757</identifier><identifier>PMID: 24150867</identifier><identifier>CODEN: ETOXFH</identifier><language>eng</language><publisher>Hoboken, NJ: Blackwell Publishing Ltd</publisher><subject>Agnatha. Pisces ; Animal and plant ecology ; Animal, plant and microbial ecology ; Animals ; antioxidant enzymes ; Antioxidants - metabolism ; Antioxidants - pharmacology ; Applied ecology ; Biological and medical sciences ; Carotenoids - pharmacology ; Carps - metabolism ; Catalase - metabolism ; cypermethrin ; Cyprinus carpio ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on vertebrates ; fish ; Fresh water ecosystems ; Freshwater ; Fundamental and applied biological sciences. Psychology ; Gills - drug effects ; Gills - metabolism ; Glutathione - metabolism ; Glutathione Peroxidase - metabolism ; Insecticides - toxicity ; Kidney - drug effects ; Kidney - metabolism ; Lipid Peroxidation - drug effects ; Liver - drug effects ; Liver - metabolism ; lycopene ; Malondialdehyde - metabolism ; Organ Specificity ; Oxidation-Reduction ; oxidative stress ; Oxidative Stress - drug effects ; pesticides ; Pyrethrins - toxicity ; pyrethroid insecticide ; Superoxide Dismutase - metabolism ; Synecology</subject><ispartof>Environmental toxicology, 2013-11, Vol.28 (11), p.609-616</ispartof><rights>Copyright © 2011 Wiley Periodicals, Inc., A Wiley Company</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Wiley Periodicals, Inc., A Wiley Company.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4207-34ce67c6e85aa0289454449255175dc6e190df186807b5ce9c0bbcf8aca656b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Ftox.20757$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Ftox.20757$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27994733$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24150867$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yonar, M. Enis</creatorcontrib><title>Protective effect of lycopene on oxidative stress and antioxidant status in Cyprinus carpio during cypermethrin exposure</title><title>Environmental toxicology</title><addtitle>Environ. Toxicol</addtitle><description>The aim of this study was to investigate the ameliorative properties of lycopene against the toxic effects of cypermethrin (CYP) by examining oxidative damage markers such as lipid peroxidation and the antioxidant defense system components in carp (Cyprinus carpio). The fish were divided into seven groups of 10 fish each and received the following treatments: group 1, no treatment; group 2, orally administered corn oil; group 3, oral lycopene (10 mg/kg body weight); group 4, exposure to 0.202 μg/L CYP; group 5, exposure to 0.202 μg/L CYP plus oral administration of 10 mg/kg lycopene; group 6, exposure to 0.404 μg/L CYP; and group 7, exposure to 0.404 μg/L CYP plus oral administration of 10 mg/kg lycopene. Treatment was continued for 28 days, and at the end of this period, blood and tissue (liver, kidney, and gill) samples were collected. Levels of malondialdehyde (MDA) and reduced glutathione (GSH) as well as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH‐Px) activities were determined in blood and tissues for measurement of oxidant‐antioxidant status. MDA level, as an index of lipid peroxidation, increased in blood and tissues. Antioxidant enzyme activities in blood and tissues were modified in CYP groups compared with controls. Administration of lycopene ameliorated these parameters. The present results suggest that administration of lycopene might alleviate CYP‐induced oxidative stress. © 2011 Wiley Periodicals, Inc. Environ Toxicol 28:609–616, 2013.</description><subject>Agnatha. Pisces</subject><subject>Animal and plant ecology</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>antioxidant enzymes</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - pharmacology</subject><subject>Applied ecology</subject><subject>Biological and medical sciences</subject><subject>Carotenoids - pharmacology</subject><subject>Carps - metabolism</subject><subject>Catalase - metabolism</subject><subject>cypermethrin</subject><subject>Cyprinus carpio</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>fish</subject><subject>Fresh water ecosystems</subject><subject>Freshwater</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gills - drug effects</subject><subject>Gills - metabolism</subject><subject>Glutathione - metabolism</subject><subject>Glutathione Peroxidase - metabolism</subject><subject>Insecticides - toxicity</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>lycopene</subject><subject>Malondialdehyde - metabolism</subject><subject>Organ Specificity</subject><subject>Oxidation-Reduction</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>pesticides</subject><subject>Pyrethrins - toxicity</subject><subject>pyrethroid insecticide</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Synecology</subject><issn>1520-4081</issn><issn>1522-7278</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkcFu1DAQhiMEoqVw4AWQJYTUS1o7sWP7iBZakAoFsRLcLMeZgEvWTm0HkrfHzS5F4mD5n5lvZjyeonhO8BnBuDpPfj6rMGf8QXFMWFWVvOLi4apxSbEgR8WTGG8wxrJhzePiqKKEYdHw42L-FHwCk-wvQND3WSHfo2ExfgQHyDvkZ9vpNR5TgBiRdl0-ya4Bl7Jbpyki69BmGYN1WRsdRutRN2XzOzLLCGEH6Ue2EMyjj1OAp8WjXg8Rnh3uk2J78Xa7eVdeXV--37y-Kg3NI5U1NdBw04BgWuNKSMoopbJijHDWZT-RuOuJaATmLTMgDW5b0wttdB61rU-K033ZMfjbCWJSOxsNDIN24KeoCG1EzSomcUZf_ofe-Cm4_LhM0brhQso6Uy8O1NTuoFN54p0Oi_r7pRl4dQB0NHrog3bGxn8cl5Ly-q7Q-Z77bQdY7uMEq7udqrxTte5Uba-_rSJnlPsMGxPM9xk6_FS5L2fq68dL9UGQL3TzBqvP9R8ve6QC</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Yonar, M. Enis</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QH</scope><scope>7ST</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>C1K</scope><scope>F1W</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>M7N</scope><scope>SOI</scope><scope>7TV</scope></search><sort><creationdate>201311</creationdate><title>Protective effect of lycopene on oxidative stress and antioxidant status in Cyprinus carpio during cypermethrin exposure</title><author>Yonar, M. Enis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4207-34ce67c6e85aa0289454449255175dc6e190df186807b5ce9c0bbcf8aca656b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Agnatha. Pisces</topic><topic>Animal and plant ecology</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>antioxidant enzymes</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - pharmacology</topic><topic>Applied ecology</topic><topic>Biological and medical sciences</topic><topic>Carotenoids - pharmacology</topic><topic>Carps - metabolism</topic><topic>Catalase - metabolism</topic><topic>cypermethrin</topic><topic>Cyprinus carpio</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>fish</topic><topic>Fresh water ecosystems</topic><topic>Freshwater</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gills - drug effects</topic><topic>Gills - metabolism</topic><topic>Glutathione - metabolism</topic><topic>Glutathione Peroxidase - metabolism</topic><topic>Insecticides - toxicity</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>lycopene</topic><topic>Malondialdehyde - metabolism</topic><topic>Organ Specificity</topic><topic>Oxidation-Reduction</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>pesticides</topic><topic>Pyrethrins - toxicity</topic><topic>pyrethroid insecticide</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Synecology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yonar, M. Enis</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Aqualine</collection><collection>Environment Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Environment Abstracts</collection><collection>Pollution Abstracts</collection><jtitle>Environmental toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yonar, M. Enis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effect of lycopene on oxidative stress and antioxidant status in Cyprinus carpio during cypermethrin exposure</atitle><jtitle>Environmental toxicology</jtitle><addtitle>Environ. Toxicol</addtitle><date>2013-11</date><risdate>2013</risdate><volume>28</volume><issue>11</issue><spage>609</spage><epage>616</epage><pages>609-616</pages><issn>1520-4081</issn><eissn>1522-7278</eissn><coden>ETOXFH</coden><abstract>The aim of this study was to investigate the ameliorative properties of lycopene against the toxic effects of cypermethrin (CYP) by examining oxidative damage markers such as lipid peroxidation and the antioxidant defense system components in carp (Cyprinus carpio). The fish were divided into seven groups of 10 fish each and received the following treatments: group 1, no treatment; group 2, orally administered corn oil; group 3, oral lycopene (10 mg/kg body weight); group 4, exposure to 0.202 μg/L CYP; group 5, exposure to 0.202 μg/L CYP plus oral administration of 10 mg/kg lycopene; group 6, exposure to 0.404 μg/L CYP; and group 7, exposure to 0.404 μg/L CYP plus oral administration of 10 mg/kg lycopene. Treatment was continued for 28 days, and at the end of this period, blood and tissue (liver, kidney, and gill) samples were collected. Levels of malondialdehyde (MDA) and reduced glutathione (GSH) as well as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH‐Px) activities were determined in blood and tissues for measurement of oxidant‐antioxidant status. MDA level, as an index of lipid peroxidation, increased in blood and tissues. Antioxidant enzyme activities in blood and tissues were modified in CYP groups compared with controls. Administration of lycopene ameliorated these parameters. The present results suggest that administration of lycopene might alleviate CYP‐induced oxidative stress. © 2011 Wiley Periodicals, Inc. Environ Toxicol 28:609–616, 2013.</abstract><cop>Hoboken, NJ</cop><pub>Blackwell Publishing Ltd</pub><pmid>24150867</pmid><doi>10.1002/tox.20757</doi><tpages>8</tpages></addata></record> |
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| subjects | Agnatha. Pisces Animal and plant ecology Animal, plant and microbial ecology Animals antioxidant enzymes Antioxidants - metabolism Antioxidants - pharmacology Applied ecology Biological and medical sciences Carotenoids - pharmacology Carps - metabolism Catalase - metabolism cypermethrin Cyprinus carpio Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates fish Fresh water ecosystems Freshwater Fundamental and applied biological sciences. Psychology Gills - drug effects Gills - metabolism Glutathione - metabolism Glutathione Peroxidase - metabolism Insecticides - toxicity Kidney - drug effects Kidney - metabolism Lipid Peroxidation - drug effects Liver - drug effects Liver - metabolism lycopene Malondialdehyde - metabolism Organ Specificity Oxidation-Reduction oxidative stress Oxidative Stress - drug effects pesticides Pyrethrins - toxicity pyrethroid insecticide Superoxide Dismutase - metabolism Synecology |
| title | Protective effect of lycopene on oxidative stress and antioxidant status in Cyprinus carpio during cypermethrin exposure |
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