Use of quantitative 1H NMR chemical shift changes for ligand docking into barnase

1 H NMR complexation-induced changes in chemical shift (CIS) of HN protons have been used to characterize the complexes of barnase with the deoxyoligonucleotides d(GC) and d(CGAC). Quantitative shift changes are used not only to locate the most probable binding site (using ring-current shifts), but...

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Veröffentlicht in:	Journal of biomolecular NMR 2009, Vol.43 (1), p.11-19
Hauptverfasser:	Cioffi, Marina, Hunter, Christopher A., Packer, Martin J., Pandya, Maya J., Williamson, Mike P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anisotropy Binding sites Biochemistry Biological and Medical Physics Biophysics Crystal structure Physics Physics and Astronomy Spectroscopy/Spectrometry
Online-Zugang:	Volltext
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