Histological Alterations on the Structure of the Excretory Renal System in Tench (Tinca tinca) After Exposure to 17-Alpha-Ethynylestradiol
This study describes the effects of 17-alpha-ethynylestradiol (EE 2 ) on the structure of the excretory system of the kidney in tench. Adult male tench were exposed to sub-lethal doses of EE 2 (50, 100 and 500 μg/kg b.w.) under semistatic conditions for a period of 30 days. The nephrosomatic index a...
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| Veröffentlicht in: | Bulletin of environmental contamination and toxicology 2013-12, Vol.91 (6), p.623-629 |
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| creator | Oropesa, A. L. Jiménez, B. Fallola, C. Pula, H. J. Cuesta, J. M. Gómez, L. |
| description | This study describes the effects of 17-alpha-ethynylestradiol (EE
2
) on the structure of the excretory system of the kidney in tench. Adult male tench were exposed to sub-lethal doses of EE
2
(50, 100 and 500 μg/kg b.w.) under semistatic conditions for a period of 30 days. The nephrosomatic index and histology (including a morphometric analysis) of the kidney were examined. Histopathological lesions in the kidney of exposed tench were: dilation of glomerular capillaries and increase in the area of the renal corpuscle, hyaline degeneration in the epithelial cells of the proximal tubules leading to necrotic changes, hemorrhages in the interstitial tissue and deposits of eosinophilic material. These lesions were observed with a greater degree of severity as the exposure doses were increased. These results indicate that long-term exposure to EE
2
could produce clear negative effects on the excretory system of the kidney in tench and consequently on their physiological functions. |
| doi_str_mv | 10.1007/s00128-013-1088-2 |
| format | Article |
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2
) on the structure of the excretory system of the kidney in tench. Adult male tench were exposed to sub-lethal doses of EE
2
(50, 100 and 500 μg/kg b.w.) under semistatic conditions for a period of 30 days. The nephrosomatic index and histology (including a morphometric analysis) of the kidney were examined. Histopathological lesions in the kidney of exposed tench were: dilation of glomerular capillaries and increase in the area of the renal corpuscle, hyaline degeneration in the epithelial cells of the proximal tubules leading to necrotic changes, hemorrhages in the interstitial tissue and deposits of eosinophilic material. These lesions were observed with a greater degree of severity as the exposure doses were increased. These results indicate that long-term exposure to EE
2
could produce clear negative effects on the excretory system of the kidney in tench and consequently on their physiological functions.</description><identifier>ISSN: 0007-4861</identifier><identifier>EISSN: 1432-0800</identifier><identifier>DOI: 10.1007/s00128-013-1088-2</identifier><identifier>PMID: 24042839</identifier><identifier>CODEN: BECTA6</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Agnatha. Pisces ; Animal, plant and microbial ecology ; Animals ; Applied ecology ; Aquatic Pollution ; Biological and medical sciences ; Cells ; Cyprinidae ; Earth and Environmental Science ; Ecotoxicology ; Ecotoxicology, biological effects of pollution ; Effects of pollution and side effects of pesticides on vertebrates ; Environment ; Environmental Chemistry ; Environmental Health ; Ethinyl Estradiol - toxicity ; Freshwater ; Fundamental and applied biological sciences. Psychology ; Histology ; Kidney - drug effects ; Kidney - pathology ; Kidneys ; Lesions ; Male ; Pollution ; Soil Science & Conservation ; Tinca tinca ; Waste Water Technology ; Water Management ; Water Pollutants, Chemical - toxicity ; Water Pollution Control</subject><ispartof>Bulletin of environmental contamination and toxicology, 2013-12, Vol.91 (6), p.623-629</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c435t-4e404f09e0588c0a31103599ae421b7dc1d75d756cd468b9ecd1cbaa60deb4143</citedby><cites>FETCH-LOGICAL-c435t-4e404f09e0588c0a31103599ae421b7dc1d75d756cd468b9ecd1cbaa60deb4143</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00128-013-1088-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00128-013-1088-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28021781$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24042839$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oropesa, A. L.</creatorcontrib><creatorcontrib>Jiménez, B.</creatorcontrib><creatorcontrib>Fallola, C.</creatorcontrib><creatorcontrib>Pula, H. J.</creatorcontrib><creatorcontrib>Cuesta, J. M.</creatorcontrib><creatorcontrib>Gómez, L.</creatorcontrib><title>Histological Alterations on the Structure of the Excretory Renal System in Tench (Tinca tinca) After Exposure to 17-Alpha-Ethynylestradiol</title><title>Bulletin of environmental contamination and toxicology</title><addtitle>Bull Environ Contam Toxicol</addtitle><addtitle>Bull Environ Contam Toxicol</addtitle><description>This study describes the effects of 17-alpha-ethynylestradiol (EE
2
) on the structure of the excretory system of the kidney in tench. Adult male tench were exposed to sub-lethal doses of EE
2
(50, 100 and 500 μg/kg b.w.) under semistatic conditions for a period of 30 days. The nephrosomatic index and histology (including a morphometric analysis) of the kidney were examined. Histopathological lesions in the kidney of exposed tench were: dilation of glomerular capillaries and increase in the area of the renal corpuscle, hyaline degeneration in the epithelial cells of the proximal tubules leading to necrotic changes, hemorrhages in the interstitial tissue and deposits of eosinophilic material. These lesions were observed with a greater degree of severity as the exposure doses were increased. These results indicate that long-term exposure to EE
2
could produce clear negative effects on the excretory system of the kidney in tench and consequently on their physiological functions.</description><subject>Agnatha. Pisces</subject><subject>Animal, plant and microbial ecology</subject><subject>Animals</subject><subject>Applied ecology</subject><subject>Aquatic Pollution</subject><subject>Biological and medical sciences</subject><subject>Cells</subject><subject>Cyprinidae</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Ecotoxicology, biological effects of pollution</subject><subject>Effects of pollution and side effects of pesticides on vertebrates</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Ethinyl Estradiol - toxicity</subject><subject>Freshwater</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Histology</subject><subject>Kidney - drug effects</subject><subject>Kidney - pathology</subject><subject>Kidneys</subject><subject>Lesions</subject><subject>Male</subject><subject>Pollution</subject><subject>Soil Science & Conservation</subject><subject>Tinca tinca</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollutants, Chemical - toxicity</subject><subject>Water Pollution Control</subject><issn>0007-4861</issn><issn>1432-0800</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kd9qFDEUxoModlt9AG8kIEK9iJ6TyexkL5eytkJBsOv1kMlkulNmkzXJQOcVfGrPuOsfBCEkcPL7vnOSj7FXCO8RoPqQAFBqAVgIBK2FfMIWqAopQAM8ZQsgSCi9xDN2ntID0aWW8jk7kwqU1MVqwb7f9CmHIdz31gx8PWQXTe6DTzx4nneO3-U42jxGx0P3s7B5tNHlECf-xXnS3E0puz3vPd86b3f8ctt7a3ie93d83ZEjaQ4hzR45cKzEejjsjNjk3eSnwaUcTduH4QV71pkhuZen84J9_bjZXt2I28_Xn67Wt8KqosxCORq-g5WDUmsLpkCEolytjFMSm6q12FYlraVt1VI3K2dbtI0xS2hdo-h7Ltjl0fcQw7eR2tf7Plk3DMa7MKYaSVYorbAg9M0_6EMYI716pqh9iRIqovBI2RhSiq6rD7HfmzjVCPUcVH0Mqqag6jmoWpLm9cl5bPau_a34lQwBb0-ASRRNF423ffrDaZBYaSROHrlEV_7exb9G_G_3H6Dyqto</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Oropesa, A. 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L. ; Jiménez, B. ; Fallola, C. ; Pula, H. J. ; Cuesta, J. M. ; Gómez, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-4e404f09e0588c0a31103599ae421b7dc1d75d756cd468b9ecd1cbaa60deb4143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Agnatha. Pisces</topic><topic>Animal, plant and microbial ecology</topic><topic>Animals</topic><topic>Applied ecology</topic><topic>Aquatic Pollution</topic><topic>Biological and medical sciences</topic><topic>Cells</topic><topic>Cyprinidae</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Ecotoxicology, biological effects of pollution</topic><topic>Effects of pollution and side effects of pesticides on vertebrates</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Ethinyl Estradiol - toxicity</topic><topic>Freshwater</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Histology</topic><topic>Kidney - drug effects</topic><topic>Kidney - pathology</topic><topic>Kidneys</topic><topic>Lesions</topic><topic>Male</topic><topic>Pollution</topic><topic>Soil Science & Conservation</topic><topic>Tinca tinca</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollutants, Chemical - toxicity</topic><topic>Water Pollution Control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oropesa, A. L.</creatorcontrib><creatorcontrib>Jiménez, B.</creatorcontrib><creatorcontrib>Fallola, C.</creatorcontrib><creatorcontrib>Pula, H. J.</creatorcontrib><creatorcontrib>Cuesta, J. 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L.</au><au>Jiménez, B.</au><au>Fallola, C.</au><au>Pula, H. J.</au><au>Cuesta, J. M.</au><au>Gómez, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Histological Alterations on the Structure of the Excretory Renal System in Tench (Tinca tinca) After Exposure to 17-Alpha-Ethynylestradiol</atitle><jtitle>Bulletin of environmental contamination and toxicology</jtitle><stitle>Bull Environ Contam Toxicol</stitle><addtitle>Bull Environ Contam Toxicol</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>91</volume><issue>6</issue><spage>623</spage><epage>629</epage><pages>623-629</pages><issn>0007-4861</issn><eissn>1432-0800</eissn><coden>BECTA6</coden><abstract>This study describes the effects of 17-alpha-ethynylestradiol (EE
2
) on the structure of the excretory system of the kidney in tench. Adult male tench were exposed to sub-lethal doses of EE
2
(50, 100 and 500 μg/kg b.w.) under semistatic conditions for a period of 30 days. The nephrosomatic index and histology (including a morphometric analysis) of the kidney were examined. Histopathological lesions in the kidney of exposed tench were: dilation of glomerular capillaries and increase in the area of the renal corpuscle, hyaline degeneration in the epithelial cells of the proximal tubules leading to necrotic changes, hemorrhages in the interstitial tissue and deposits of eosinophilic material. These lesions were observed with a greater degree of severity as the exposure doses were increased. These results indicate that long-term exposure to EE
2
could produce clear negative effects on the excretory system of the kidney in tench and consequently on their physiological functions.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>24042839</pmid><doi>10.1007/s00128-013-1088-2</doi><tpages>7</tpages></addata></record> |
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| ispartof | Bulletin of environmental contamination and toxicology, 2013-12, Vol.91 (6), p.623-629 |
| issn | 0007-4861 1432-0800 |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Agnatha. Pisces Animal, plant and microbial ecology Animals Applied ecology Aquatic Pollution Biological and medical sciences Cells Cyprinidae Earth and Environmental Science Ecotoxicology Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Environment Environmental Chemistry Environmental Health Ethinyl Estradiol - toxicity Freshwater Fundamental and applied biological sciences. Psychology Histology Kidney - drug effects Kidney - pathology Kidneys Lesions Male Pollution Soil Science & Conservation Tinca tinca Waste Water Technology Water Management Water Pollutants, Chemical - toxicity Water Pollution Control |
| title | Histological Alterations on the Structure of the Excretory Renal System in Tench (Tinca tinca) After Exposure to 17-Alpha-Ethynylestradiol |
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