A matrix approach to guide IHC-based tissue biomarker development in oncology drug discovery

Immunohistochemistry (IHC) is a core platform for the analysis of tissue samples, and there is an increasing demand for reliable and quantitative IHC‐based tissue biomarkers in oncology clinical research and development (R&D) environments. Biomarker assay and drug development proceed in parallel...

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Veröffentlicht in:	The Journal of pathology 2014-01, Vol.232 (2), p.190-198
Hauptverfasser:	Smith, Neil R, Womack, Christopher
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - therapeutic use assay validation Biomarkers, Tumor - analysis Drug Discovery - methods Humans Immunohistochemistry Medical Oncology - methods Neoplasms - chemistry Neoplasms - drug therapy Neoplasms - pathology oncology drug development Predictive Value of Tests Reproducibility of Results Treatment Outcome Workflow
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