Single measurement of hemoglobin predicts outcome of HCC patients
Anemia is a common complication in several types of cancer including hepatocellular carcinoma (HCC). The prognostic potential of hemoglobin (Hb) levels has not yet been investigated in HCC patients. One hundred and ninety-nine patients were prospectively recruited and Hb levels were determined. Hb l...
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| Veröffentlicht in: | Medical oncology (Northwood, London, England) London, England), 2014, Vol.31 (1), p.806-806, Article 806 |
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| creator | Finkelmeier, Fabian Bettinger, Dominik Köberle, Verena Schultheiß, Michael Zeuzem, Stefan Kronenberger, Bernd Piiper, Albrecht Waidmann, Oliver |
| description | Anemia is a common complication in several types of cancer including hepatocellular carcinoma (HCC). The prognostic potential of hemoglobin (Hb) levels has not yet been investigated in HCC patients. One hundred and ninety-nine patients were prospectively recruited and Hb levels were determined. Hb levels were compared to the stages of liver cirrhosis and HCC stages. The association of the Hb levels and overall survival (OS) was assessed by univariate and multivariate Cox regression models. The relation of Hb levels and OS was further validated in an independent cohort of 87 HCC patients. Hb levels negatively correlated with the stage of liver cirrhosis (model of end stage liver disease score and Child-Pugh stage) and differed between stages of HCC. Low Hb levels (≤13 g/dl) were associated with higher mortality in the test [hazard ratio (HR) 2.422, 95 % confidence interval (CI) 1.357–4.322,
P
= 0.003] as well in the validation cohort (HR 2.486, 95 % CI 1.097–5.632,
P
= 0.029) in univariate Cox regression model. Low Hb levels were associated with mortality independently from the tumor stage, age, gender and the C-reactive protein levels in a multivariate Cox regression model. Anemia should be considered as a risk factor for mortality in HCC patients. |
| doi_str_mv | 10.1007/s12032-013-0806-2 |
| format | Article |
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P
= 0.003] as well in the validation cohort (HR 2.486, 95 % CI 1.097–5.632,
P
= 0.029) in univariate Cox regression model. Low Hb levels were associated with mortality independently from the tumor stage, age, gender and the C-reactive protein levels in a multivariate Cox regression model. Anemia should be considered as a risk factor for mortality in HCC patients.</description><identifier>ISSN: 1357-0560</identifier><identifier>EISSN: 1559-131X</identifier><identifier>DOI: 10.1007/s12032-013-0806-2</identifier><identifier>PMID: 24326985</identifier><identifier>CODEN: MONCEZ</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular - blood ; Carcinoma, Hepatocellular - diagnosis ; Case-Control Studies ; Cell Proliferation ; End Stage Liver Disease - blood ; Erythrocytes ; Female ; Gene Expression Regulation, Neoplastic ; Hematology ; Hemoglobins - biosynthesis ; Humans ; Internal Medicine ; Liver Cirrhosis - blood ; Liver Neoplasms - blood ; Liver Neoplasms - diagnosis ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Original Paper ; Pathology ; Proportional Hazards Models ; Prospective Studies ; Regression Analysis ; Risk Factors ; Treatment Outcome</subject><ispartof>Medical oncology (Northwood, London, England), 2014, Vol.31 (1), p.806-806, Article 806</ispartof><rights>Springer Science+Business Media New York 2013</rights><rights>Springer Science+Business Media New York 2014</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-9de1cca06af44919a8ccea4223b8a3f411b8e231f6a5762a460c4f64470fec8a3</citedby><cites>FETCH-LOGICAL-c372t-9de1cca06af44919a8ccea4223b8a3f411b8e231f6a5762a460c4f64470fec8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12032-013-0806-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12032-013-0806-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24326985$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Finkelmeier, Fabian</creatorcontrib><creatorcontrib>Bettinger, Dominik</creatorcontrib><creatorcontrib>Köberle, Verena</creatorcontrib><creatorcontrib>Schultheiß, Michael</creatorcontrib><creatorcontrib>Zeuzem, Stefan</creatorcontrib><creatorcontrib>Kronenberger, Bernd</creatorcontrib><creatorcontrib>Piiper, Albrecht</creatorcontrib><creatorcontrib>Waidmann, Oliver</creatorcontrib><title>Single measurement of hemoglobin predicts outcome of HCC patients</title><title>Medical oncology (Northwood, London, England)</title><addtitle>Med Oncol</addtitle><addtitle>Med Oncol</addtitle><description>Anemia is a common complication in several types of cancer including hepatocellular carcinoma (HCC). The prognostic potential of hemoglobin (Hb) levels has not yet been investigated in HCC patients. One hundred and ninety-nine patients were prospectively recruited and Hb levels were determined. Hb levels were compared to the stages of liver cirrhosis and HCC stages. The association of the Hb levels and overall survival (OS) was assessed by univariate and multivariate Cox regression models. The relation of Hb levels and OS was further validated in an independent cohort of 87 HCC patients. Hb levels negatively correlated with the stage of liver cirrhosis (model of end stage liver disease score and Child-Pugh stage) and differed between stages of HCC. Low Hb levels (≤13 g/dl) were associated with higher mortality in the test [hazard ratio (HR) 2.422, 95 % confidence interval (CI) 1.357–4.322,
P
= 0.003] as well in the validation cohort (HR 2.486, 95 % CI 1.097–5.632,
P
= 0.029) in univariate Cox regression model. Low Hb levels were associated with mortality independently from the tumor stage, age, gender and the C-reactive protein levels in a multivariate Cox regression model. Anemia should be considered as a risk factor for mortality in HCC patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Hepatocellular - blood</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Case-Control Studies</subject><subject>Cell Proliferation</subject><subject>End Stage Liver Disease - blood</subject><subject>Erythrocytes</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Hematology</subject><subject>Hemoglobins - biosynthesis</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Neoplasms - blood</subject><subject>Liver Neoplasms - diagnosis</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>Pathology</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Regression Analysis</subject><subject>Risk Factors</subject><subject>Treatment Outcome</subject><issn>1357-0560</issn><issn>1559-131X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kE1LxDAQhoMo7rr6A7xIwYuXaL7bHpfFL1jwoIK3kGana5e2qUl78N-b0lVE8DQD88w7w4PQOSXXlJD0JlBGOMOEckwyojA7QHMqZY4pp2-HsecyxUQqMkMnIewIYVSy_BjNmOBM5Zmco-Vz1W5rSBowYfDQQNsnrkzeoXHb2hVVm3QeNpXtQ-KG3roGxvHDapV0pq8iHU7RUWnqAGf7ukCvd7cvqwe8frp_XC3X2PKU9TjfALXWEGVKIXKam8xaMIIxXmSGl4LSIgPGaamMTBUzQhErSiVESkqwEVmgqym38-5jgNDrpgoW6tq04IagqVCp4lJJFtHLP-jODb6N30UqlYSlKuORohNlvQvBQ6k7XzXGf2pK9OhXT3519KtHv3pMvtgnD0UDm5-Nb6ERYBMQ4qjdgv91-t_UL40GhDw</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Finkelmeier, Fabian</creator><creator>Bettinger, Dominik</creator><creator>Köberle, Verena</creator><creator>Schultheiß, Michael</creator><creator>Zeuzem, Stefan</creator><creator>Kronenberger, Bernd</creator><creator>Piiper, Albrecht</creator><creator>Waidmann, Oliver</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Single measurement of hemoglobin predicts outcome of HCC patients</title><author>Finkelmeier, Fabian ; Bettinger, Dominik ; Köberle, Verena ; Schultheiß, Michael ; Zeuzem, Stefan ; Kronenberger, Bernd ; Piiper, Albrecht ; Waidmann, Oliver</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-9de1cca06af44919a8ccea4223b8a3f411b8e231f6a5762a460c4f64470fec8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Hepatocellular - blood</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Case-Control Studies</topic><topic>Cell Proliferation</topic><topic>End Stage Liver Disease - blood</topic><topic>Erythrocytes</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Hematology</topic><topic>Hemoglobins - biosynthesis</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Neoplasms - blood</topic><topic>Liver Neoplasms - diagnosis</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>Pathology</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Regression Analysis</topic><topic>Risk Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Finkelmeier, Fabian</creatorcontrib><creatorcontrib>Bettinger, Dominik</creatorcontrib><creatorcontrib>Köberle, Verena</creatorcontrib><creatorcontrib>Schultheiß, Michael</creatorcontrib><creatorcontrib>Zeuzem, Stefan</creatorcontrib><creatorcontrib>Kronenberger, Bernd</creatorcontrib><creatorcontrib>Piiper, Albrecht</creatorcontrib><creatorcontrib>Waidmann, Oliver</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Medical oncology (Northwood, London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Finkelmeier, Fabian</au><au>Bettinger, Dominik</au><au>Köberle, Verena</au><au>Schultheiß, Michael</au><au>Zeuzem, Stefan</au><au>Kronenberger, Bernd</au><au>Piiper, Albrecht</au><au>Waidmann, Oliver</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Single measurement of hemoglobin predicts outcome of HCC patients</atitle><jtitle>Medical oncology (Northwood, London, England)</jtitle><stitle>Med Oncol</stitle><addtitle>Med Oncol</addtitle><date>2014</date><risdate>2014</risdate><volume>31</volume><issue>1</issue><spage>806</spage><epage>806</epage><pages>806-806</pages><artnum>806</artnum><issn>1357-0560</issn><eissn>1559-131X</eissn><coden>MONCEZ</coden><abstract>Anemia is a common complication in several types of cancer including hepatocellular carcinoma (HCC). The prognostic potential of hemoglobin (Hb) levels has not yet been investigated in HCC patients. One hundred and ninety-nine patients were prospectively recruited and Hb levels were determined. Hb levels were compared to the stages of liver cirrhosis and HCC stages. The association of the Hb levels and overall survival (OS) was assessed by univariate and multivariate Cox regression models. The relation of Hb levels and OS was further validated in an independent cohort of 87 HCC patients. Hb levels negatively correlated with the stage of liver cirrhosis (model of end stage liver disease score and Child-Pugh stage) and differed between stages of HCC. Low Hb levels (≤13 g/dl) were associated with higher mortality in the test [hazard ratio (HR) 2.422, 95 % confidence interval (CI) 1.357–4.322,
P
= 0.003] as well in the validation cohort (HR 2.486, 95 % CI 1.097–5.632,
P
= 0.029) in univariate Cox regression model. Low Hb levels were associated with mortality independently from the tumor stage, age, gender and the C-reactive protein levels in a multivariate Cox regression model. Anemia should be considered as a risk factor for mortality in HCC patients.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>24326985</pmid><doi>10.1007/s12032-013-0806-2</doi><tpages>1</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Carcinoma, Hepatocellular - blood Carcinoma, Hepatocellular - diagnosis Case-Control Studies Cell Proliferation End Stage Liver Disease - blood Erythrocytes Female Gene Expression Regulation, Neoplastic Hematology Hemoglobins - biosynthesis Humans Internal Medicine Liver Cirrhosis - blood Liver Neoplasms - blood Liver Neoplasms - diagnosis Male Medicine Medicine & Public Health Middle Aged Oncology Original Paper Pathology Proportional Hazards Models Prospective Studies Regression Analysis Risk Factors Treatment Outcome |
| title | Single measurement of hemoglobin predicts outcome of HCC patients |
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