A critical appraisal of the duration of chronic animal toxicity studies

One method of assessing the contribution of studies of longer than 6 months to a safety evaluation program is to compare retrospectively the findings in toxicity tests carried out for 6 months or less with those observed after 6 months. The Centre for Medicines Research has therefore established a d...

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Veröffentlicht in:	Regul. Toxicol. Pharmacol.; (United States) 1986-03, Vol.6 (1), p.66-72
Hauptverfasser:	Lumley, Cynthia E., Walker, Stuart R.
Format:	Artikel
Sprache:	eng
Schlagworte:	560305 - Chemicals Metabolism & Toxicology- Vertebrates- (-1987) ANIMALS Biological and medical sciences CARCINOGENS CHRONIC EXPOSURE DATA DATA COMPILATION DOGS Drug Evaluation Drug Industry Drug-Related Side Effects and Adverse Reactions EUROPE EVALUATION General aspects. Methods Humans INFORMATION MAMMALS Medical sciences RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RATS Research Design RODENTS SAFETY Species Specificity Time Factors TOXICITY Toxicology VERTEBRATES XENOBIOTICS
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