Novel self-emulsifying formulation of quercetin for improved in vivo antioxidant potential: Implications for drug-induced cardiotoxicity and nephrotoxicity

Quercetin (QT) was formulated into a novel self-emulsifying drug delivery system (SEDDS) to improve its oral bioavailability and antioxidant potential compared to free drug. Capmul MCM was selected as the oily phase on the basis of optimum solubility of QT in oil. Tween 20 and ethanol were selected...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Free radical biology & medicine 2013-12, Vol.65, p.117-130
Hauptverfasser:	Jain, Sanyog, Jain, Amit K, Pohekar, Milind, Thanki, Kaushik
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - adverse effects antioxidant activity Antioxidants - administration & dosage Antioxidants - pharmacokinetics bioavailability Biological Availability Caco-2 Cells Cardiotoxicity - prevention & control Chemistry, Pharmaceutical confocal laser scanning microscopy correlation Cyclosporine - adverse effects Doxorubicin - adverse effects Drug Delivery Systems - methods drugs Emulsifying Agents - administration & dosage Emulsifying Agents - pharmacokinetics emulsions Emulsions - pharmacokinetics Emulsions - pharmacology ethanol Female fluorescence gastrointestinal system guidelines human cell lines Humans Kidney Diseases - chemically induced Kidney Diseases - prevention & control Microscopy, Confocal nephrotoxicity oils pharmacokinetics polysorbates quercetin Quercetin - administration & dosage Quercetin - pharmacokinetics Rats Rats, Sprague-Dawley solubility surfactants
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!