The biological basis and measurement of thresholds
For practical purposes many methods for the determination of threshold or no-effect levels depend on mathematical models of varying complexity. The purpose of this paper is to emphasize the kind of biological information required for a logical approach to the problem. This includes measures of recei...
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| Veröffentlicht in: | Annual review of pharmacology and toxicology 1986-01, Vol.26 (1), p.39-58 |
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| container_title | Annual review of pharmacology and toxicology |
| container_volume | 26 |
| creator | Aldridge, W N |
| description | For practical purposes many methods for the determination of threshold or no-effect levels depend on mathematical models of varying complexity. The purpose of this paper is to emphasize the kind of biological information required for a logical approach to the problem. This includes measures of received dose rather than the concentration in the environment external to the animal or human, and knowledge of mechanisms derived from experimental studies on animals. |
| doi_str_mv | 10.1146/annurev.pa.26.040186.000351 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0362-1642 |
| ispartof | Annual review of pharmacology and toxicology, 1986-01, Vol.26 (1), p.39-58 |
| issn | 0362-1642 1545-4304 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_14668585 |
| source | Annual Reviews; MEDLINE |
| subjects | Acrylamides Animals Carcinogens Chemical Phenomena Chemistry Environmental Pollutants Hexanones Humans Mutagens Nervous System Diseases - chemically induced Organophosphorus Compounds Poisons |
| title | The biological basis and measurement of thresholds |
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