Innovative Therapies in Ewing Sarcoma
Ewing Sarcoma is a developmental tumor characterized by balanced chromosomal translocations and formation of new fusion genes, which are the main hallmark of this rare entity. Despite the vast knowledge regarding the molecular aspects of this rare malignancy obtained in the last few years, including...
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| Veröffentlicht in: | Advances in anatomic pathology 2014-01, Vol.21 (1), p.49-67 |
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| container_title | Advances in anatomic pathology |
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| creator | Amaral, Ana Teresa Ordóñez, José Luis Otero-Motta, Ana Pastora García-Domínguez, Daniel J Sevillano, María Victoria de Álava, Enrique |
| description | Ewing Sarcoma is a developmental tumor characterized by balanced chromosomal translocations and formation of new fusion genes, which are the main hallmark of this rare entity. Despite the vast knowledge regarding the molecular aspects of this rare malignancy obtained in the last few years, including the discovery of new therapeutic targets, many questions still remain open. In this review we focus on the research on targeted therapies in this malignancy, and discussed some bottlenecks related to this such as the possible role of pathologists, the availability of samples, the lack of appropriate animal models, and the resources needed to carry out preclinical and clinical research. |
| doi_str_mv | 10.1097/PAP.0000000000000003 |
| format | Article |
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Despite the vast knowledge regarding the molecular aspects of this rare malignancy obtained in the last few years, including the discovery of new therapeutic targets, many questions still remain open. In this review we focus on the research on targeted therapies in this malignancy, and discussed some bottlenecks related to this such as the possible role of pathologists, the availability of samples, the lack of appropriate animal models, and the resources needed to carry out preclinical and clinical research.</description><identifier>ISSN: 1072-4109</identifier><identifier>EISSN: 1533-4031</identifier><identifier>DOI: 10.1097/PAP.0000000000000003</identifier><identifier>PMID: 24316910</identifier><language>eng</language><publisher>United States: by Lippincott Williams & Wilkins</publisher><subject>Animals ; Bone Neoplasms - genetics ; Bone Neoplasms - therapy ; Disease Models, Animal ; Humans ; Molecular Targeted Therapy - methods ; Sarcoma, Ewing - genetics ; Sarcoma, Ewing - therapy ; Therapies, Investigational</subject><ispartof>Advances in anatomic pathology, 2014-01, Vol.21 (1), p.49-67</ispartof><rights>2014 by Lippincott Williams & Wilkins.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4036-14382ffb2469f1953c2b57c10799d8088107b5a8d2e7a53927a306d621b9bb7c3</citedby><cites>FETCH-LOGICAL-c4036-14382ffb2469f1953c2b57c10799d8088107b5a8d2e7a53927a306d621b9bb7c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24316910$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amaral, Ana Teresa</creatorcontrib><creatorcontrib>Ordóñez, José Luis</creatorcontrib><creatorcontrib>Otero-Motta, Ana Pastora</creatorcontrib><creatorcontrib>García-Domínguez, Daniel J</creatorcontrib><creatorcontrib>Sevillano, María Victoria</creatorcontrib><creatorcontrib>de Álava, Enrique</creatorcontrib><title>Innovative Therapies in Ewing Sarcoma</title><title>Advances in anatomic pathology</title><addtitle>Adv Anat Pathol</addtitle><description>Ewing Sarcoma is a developmental tumor characterized by balanced chromosomal translocations and formation of new fusion genes, which are the main hallmark of this rare entity. 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| ispartof | Advances in anatomic pathology, 2014-01, Vol.21 (1), p.49-67 |
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| language | eng |
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| source | MEDLINE; Journals@Ovid Ovid Autoload |
| subjects | Animals Bone Neoplasms - genetics Bone Neoplasms - therapy Disease Models, Animal Humans Molecular Targeted Therapy - methods Sarcoma, Ewing - genetics Sarcoma, Ewing - therapy Therapies, Investigational |
| title | Innovative Therapies in Ewing Sarcoma |
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