Postmortem heart weight: relation to body size and effects of cardiovascular disease and cancer
Abstract Background Gender, body weight, and cardiovascular disease (CVD) are all variables known to influence human heart weight. The impact of cancer is less studied, and the influence of age is not unequivocal. We aimed to describe the relationship between body size and heart weight in a large au...
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| Veröffentlicht in: | Cardiovascular pathology 2014, Vol.23 (1), p.5-11 |
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| creator | Kumar, Neena Theresa Liestøl, Knut Løberg, Else Marit Reims, Henrik Mikael Mæhlen, Jan |
| description | Abstract Background Gender, body weight, and cardiovascular disease (CVD) are all variables known to influence human heart weight. The impact of cancer is less studied, and the influence of age is not unequivocal. We aimed to describe the relationship between body size and heart weight in a large autopsy cohort and to compare heart weight in patients with cancer, CVD, and other diseases. Methods and Results Registered information, including cause of death, evidence of cancer and/or CVD, heart weight, body weight, and height, was extracted from the autopsy reports of 1410 persons (805 men, mean age 66.5 years and 605 women, mean age 70.6 years). The study population was divided in four groups according to cause of death; cancer ( n =349), CVD ( n =470), mixed group who died from cancer and CVD and/or lung disease ( n =263), and a reference group with patients who did not die from any of these conditions ( n =328). In this last group, heart weight correlated only slightly better with body surface area than body weight, and nomograms based on body weight are presented. Compared to the reference group (mean heart weight: 426 g and 351 g in men and women, respectively), heart weight was significantly lower (men: P |
| doi_str_mv | 10.1016/j.carpath.2013.09.001 |
| format | Article |
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The impact of cancer is less studied, and the influence of age is not unequivocal. We aimed to describe the relationship between body size and heart weight in a large autopsy cohort and to compare heart weight in patients with cancer, CVD, and other diseases. Methods and Results Registered information, including cause of death, evidence of cancer and/or CVD, heart weight, body weight, and height, was extracted from the autopsy reports of 1410 persons (805 men, mean age 66.5 years and 605 women, mean age 70.6 years). The study population was divided in four groups according to cause of death; cancer ( n =349), CVD ( n =470), mixed group who died from cancer and CVD and/or lung disease ( n =263), and a reference group with patients who did not die from any of these conditions ( n =328). In this last group, heart weight correlated only slightly better with body surface area than body weight, and nomograms based on body weight are presented. Compared to the reference group (mean heart weight: 426 g and 351 g in men and women, respectively), heart weight was significantly lower (men: P <.05, women: P <.001) in cancer patients (men: 392 g, women: 309 g) and higher ( P <.001) in patients who died from CVD (men: 550 g, women: 430 g). Similar results were obtained in linear regression models adjusted for body weight and age. Among CVD, heart valve disease had the greatest impact on heart weight, followed by old myocardial infarction, coronary atherosclerosis, and hypertension. Absolute heart weight decreased with age, but we demonstrated an increase relative to body weight. Conclusion The weight of the human heart is influenced by various disease processes, in addition to body weight, gender, and age. While the most prevalent types of CVD are associated with increased heart weight, patients who die from cancer have lower average heart weight than other patient groups. The latter finding, however, is diminished when adjusting for body weight. Summary The present study demonstrates that the weight of the human heart is influenced by various disease processes like cancer and CVD, in addition to body weight, gender and, possibly, age.</description><identifier>ISSN: 1054-8807</identifier><identifier>EISSN: 1879-1336</identifier><identifier>DOI: 10.1016/j.carpath.2013.09.001</identifier><identifier>PMID: 24121021</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Autopsy ; Body Surface Area ; Body Weight ; Cancer ; Cardiovascular diseases ; Cardiovascular Diseases - pathology ; Cause of Death ; Female ; Heart ; Heart weight ; Humans ; Linear Models ; Logistic Models ; Male ; Middle Aged ; Neoplasms - pathology ; Odds Ratio ; Organ Size ; Pathology ; Retrospective Studies ; Sex Factors ; Young Adult</subject><ispartof>Cardiovascular pathology, 2014, Vol.23 (1), p.5-11</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>2013.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-422544cef8aa2ec0dfd0b29b0fc5a60b9f2a9e6ed97fca999af4cd293e79b6923</citedby><cites>FETCH-LOGICAL-c420t-422544cef8aa2ec0dfd0b29b0fc5a60b9f2a9e6ed97fca999af4cd293e79b6923</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.carpath.2013.09.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,4022,27922,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24121021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kumar, Neena Theresa</creatorcontrib><creatorcontrib>Liestøl, Knut</creatorcontrib><creatorcontrib>Løberg, Else Marit</creatorcontrib><creatorcontrib>Reims, Henrik Mikael</creatorcontrib><creatorcontrib>Mæhlen, Jan</creatorcontrib><title>Postmortem heart weight: relation to body size and effects of cardiovascular disease and cancer</title><title>Cardiovascular pathology</title><addtitle>Cardiovasc Pathol</addtitle><description>Abstract Background Gender, body weight, and cardiovascular disease (CVD) are all variables known to influence human heart weight. The impact of cancer is less studied, and the influence of age is not unequivocal. We aimed to describe the relationship between body size and heart weight in a large autopsy cohort and to compare heart weight in patients with cancer, CVD, and other diseases. Methods and Results Registered information, including cause of death, evidence of cancer and/or CVD, heart weight, body weight, and height, was extracted from the autopsy reports of 1410 persons (805 men, mean age 66.5 years and 605 women, mean age 70.6 years). The study population was divided in four groups according to cause of death; cancer ( n =349), CVD ( n =470), mixed group who died from cancer and CVD and/or lung disease ( n =263), and a reference group with patients who did not die from any of these conditions ( n =328). In this last group, heart weight correlated only slightly better with body surface area than body weight, and nomograms based on body weight are presented. Compared to the reference group (mean heart weight: 426 g and 351 g in men and women, respectively), heart weight was significantly lower (men: P <.05, women: P <.001) in cancer patients (men: 392 g, women: 309 g) and higher ( P <.001) in patients who died from CVD (men: 550 g, women: 430 g). Similar results were obtained in linear regression models adjusted for body weight and age. Among CVD, heart valve disease had the greatest impact on heart weight, followed by old myocardial infarction, coronary atherosclerosis, and hypertension. Absolute heart weight decreased with age, but we demonstrated an increase relative to body weight. Conclusion The weight of the human heart is influenced by various disease processes, in addition to body weight, gender, and age. While the most prevalent types of CVD are associated with increased heart weight, patients who die from cancer have lower average heart weight than other patient groups. The latter finding, however, is diminished when adjusting for body weight. Summary The present study demonstrates that the weight of the human heart is influenced by various disease processes like cancer and CVD, in addition to body weight, gender and, possibly, age.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Autopsy</subject><subject>Body Surface Area</subject><subject>Body Weight</subject><subject>Cancer</subject><subject>Cardiovascular diseases</subject><subject>Cardiovascular Diseases - pathology</subject><subject>Cause of Death</subject><subject>Female</subject><subject>Heart</subject><subject>Heart weight</subject><subject>Humans</subject><subject>Linear Models</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasms - pathology</subject><subject>Odds Ratio</subject><subject>Organ Size</subject><subject>Pathology</subject><subject>Retrospective Studies</subject><subject>Sex Factors</subject><subject>Young Adult</subject><issn>1054-8807</issn><issn>1879-1336</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P1DAMhisEYpeFnwDKkUuLk6Yf4QBarfiSVgIJOEdu4jAZOs2QpIuGX09GM3Dgwsk5PK_tPK6qpxwaDrx_sW0Mxj3mTSOAtw2oBoDfqy75OKiat21_v7yhk_U4wnBRPUppCwCjlPJhdSEkFxwEv6z0p5DyLsRMO7YhjJn9JP9tk1-ySDNmHxaWA5uCPbDkfxHDxTJyjkxOLDhWdrA-3GEy64yRWZ8I04kyuBiKj6sHDudET871qvr69s2Xm_f17cd3H26ub2sjBeRaCtFJaciNiIIMWGdhEmoCZzrsYVJOoKKerBqcQaUUOmmsUC0NauqVaK-q56e--xh-rJSy3vlkaJ5xobAmzWXft0M3DKqg3Qk1MaQUyel99DuMB81BH93qrT671Ue3GpQubkvu2XnEOu3I_k39kVmA1yeAykfvPEWdjKdiwfpYhGkb_H9HvPqng5n94g3O3-lAaRvWuBSLmuskNOjPxwMf78vbkh7U2P4GyP-jyA</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Kumar, Neena Theresa</creator><creator>Liestøl, Knut</creator><creator>Løberg, Else Marit</creator><creator>Reims, Henrik Mikael</creator><creator>Mæhlen, Jan</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Postmortem heart weight: relation to body size and effects of cardiovascular disease and cancer</title><author>Kumar, Neena Theresa ; Liestøl, Knut ; Løberg, Else Marit ; Reims, Henrik Mikael ; Mæhlen, Jan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-422544cef8aa2ec0dfd0b29b0fc5a60b9f2a9e6ed97fca999af4cd293e79b6923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Autopsy</topic><topic>Body Surface Area</topic><topic>Body Weight</topic><topic>Cancer</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular Diseases - pathology</topic><topic>Cause of Death</topic><topic>Female</topic><topic>Heart</topic><topic>Heart weight</topic><topic>Humans</topic><topic>Linear Models</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasms - pathology</topic><topic>Odds Ratio</topic><topic>Organ Size</topic><topic>Pathology</topic><topic>Retrospective Studies</topic><topic>Sex Factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kumar, Neena Theresa</creatorcontrib><creatorcontrib>Liestøl, Knut</creatorcontrib><creatorcontrib>Løberg, Else Marit</creatorcontrib><creatorcontrib>Reims, Henrik Mikael</creatorcontrib><creatorcontrib>Mæhlen, Jan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cardiovascular pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kumar, Neena Theresa</au><au>Liestøl, Knut</au><au>Løberg, Else Marit</au><au>Reims, Henrik Mikael</au><au>Mæhlen, Jan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postmortem heart weight: relation to body size and effects of cardiovascular disease and cancer</atitle><jtitle>Cardiovascular pathology</jtitle><addtitle>Cardiovasc Pathol</addtitle><date>2014</date><risdate>2014</risdate><volume>23</volume><issue>1</issue><spage>5</spage><epage>11</epage><pages>5-11</pages><issn>1054-8807</issn><eissn>1879-1336</eissn><abstract>Abstract Background Gender, body weight, and cardiovascular disease (CVD) are all variables known to influence human heart weight. The impact of cancer is less studied, and the influence of age is not unequivocal. We aimed to describe the relationship between body size and heart weight in a large autopsy cohort and to compare heart weight in patients with cancer, CVD, and other diseases. Methods and Results Registered information, including cause of death, evidence of cancer and/or CVD, heart weight, body weight, and height, was extracted from the autopsy reports of 1410 persons (805 men, mean age 66.5 years and 605 women, mean age 70.6 years). The study population was divided in four groups according to cause of death; cancer ( n =349), CVD ( n =470), mixed group who died from cancer and CVD and/or lung disease ( n =263), and a reference group with patients who did not die from any of these conditions ( n =328). In this last group, heart weight correlated only slightly better with body surface area than body weight, and nomograms based on body weight are presented. Compared to the reference group (mean heart weight: 426 g and 351 g in men and women, respectively), heart weight was significantly lower (men: P <.05, women: P <.001) in cancer patients (men: 392 g, women: 309 g) and higher ( P <.001) in patients who died from CVD (men: 550 g, women: 430 g). Similar results were obtained in linear regression models adjusted for body weight and age. Among CVD, heart valve disease had the greatest impact on heart weight, followed by old myocardial infarction, coronary atherosclerosis, and hypertension. Absolute heart weight decreased with age, but we demonstrated an increase relative to body weight. Conclusion The weight of the human heart is influenced by various disease processes, in addition to body weight, gender, and age. While the most prevalent types of CVD are associated with increased heart weight, patients who die from cancer have lower average heart weight than other patient groups. The latter finding, however, is diminished when adjusting for body weight. Summary The present study demonstrates that the weight of the human heart is influenced by various disease processes like cancer and CVD, in addition to body weight, gender and, possibly, age.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24121021</pmid><doi>10.1016/j.carpath.2013.09.001</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Age Factors Aged Aged, 80 and over Autopsy Body Surface Area Body Weight Cancer Cardiovascular diseases Cardiovascular Diseases - pathology Cause of Death Female Heart Heart weight Humans Linear Models Logistic Models Male Middle Aged Neoplasms - pathology Odds Ratio Organ Size Pathology Retrospective Studies Sex Factors Young Adult |
| title | Postmortem heart weight: relation to body size and effects of cardiovascular disease and cancer |
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