Second primary malignancies in head and neck cancer patients: High prevalence of curable-stage disease
Background and purpose Patients treated for squamous cell carcinoma of the head and neck (HNSCC) carry a high risk of second primary malignancies (SPM). Recently, computed tomography (CT) of the chest was shown to significantly decrease the risk of death due to bronchial carcinoma (BC) in a cohort o...
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| Veröffentlicht in: | Strahlentherapie und Onkologie 2013-10, Vol.189 (10), p.874-880 |
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| creator | Wolff, H.A. Wolff, C.R.M. Hess, C.F. Jung, K. Sennhenn-Kirchner, S. Hinterthaner, M. Müller-Dornieden, A. Körber, W. Marten-Engelke, K. Roedel, R. Christiansen, H. Engelke, C. |
| description | Background and purpose
Patients treated for squamous cell carcinoma of the head and neck (HNSCC) carry a high risk of second primary malignancies (SPM). Recently, computed tomography (CT) of the chest was shown to significantly decrease the risk of death due to bronchial carcinoma (BC) in a cohort of smokers whose risk of BC is increased but might be lower than that of patients previously treated for HNSCC. Thus, the present study evaluated the potential benefit of CT and other examinations in the detection of SPM in HNSCC patients.
Patients and methods
Between July 2008 and November 2011, 118 participants underwent a prospective, systematic examination for SPM (13 women, 105 men, median age 62 years). All patients had been previously treated for HNSCC and showed no recurrence or distant metastases at the time of the study start. CT scans, ear–nose–throat endoscopy, and endoscopy of the esophagus and stomach were performed.
Results
Overall, 33 suspicious findings were clarified by additional investigations. In all, 26 SPM were confirmed in 21 of 118 patients (18 %; 10 lung, 7 HNSCC, 3 gastrointestinal, 1 renal). Eighteen of these 21 patients (86 %) underwent therapy with curative intent.
Conclusion
The examinations revealed a high prevalence of curable stage SPM in HNSCC patients. Adapting a surveillance scheme including a chest CT is recommended. |
| doi_str_mv | 10.1007/s00066-013-0404-4 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1466373053</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3109445341</sourcerecordid><originalsourceid>FETCH-LOGICAL-c324t-629a799e291acfc2078df2291510dc436498a14f404dc1cabf27364230af77453</originalsourceid><addsrcrecordid>eNp1kE1LxDAQhoMo7rr6A7xIwYuX6OSjSQNeZPELBA8qeAvZNF27tumatAf_vVm6igieQjLPvJl5EDomcE4A5EUEACEwEIaBA8d8B00JZwqDUq-7aApEKixJXkzQQYwrACK44vtoQlnBqWBiii6fnO18ma1D3ZrwmbWmqZfeeFu7mNU-e3OmzEwCvLPvmU0FF7K16Wvn-3iI9irTRHe0PWfo5eb6eX6HHx5v7-dXD9gyynssqDJSKUcVMbayFGRRVjTdcgKl5SwNVRjCq7RCaYk1i4rK9EgZmEpKnrMZOhtz16H7GFzsdVtH65rGeNcNURMuBJMMcpbQ0z_oqhuCT9MliuekEERuAslI2dDFGFylt_trAnqjVo9qdVKrN2o1Tz0n2-Rh0bryp-PbZQLoCMRU8ksXfn39b-oXKk2BHg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1445186175</pqid></control><display><type>article</type><title>Second primary malignancies in head and neck cancer patients: High prevalence of curable-stage disease</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Wolff, H.A. ; Wolff, C.R.M. ; Hess, C.F. ; Jung, K. ; Sennhenn-Kirchner, S. ; Hinterthaner, M. ; Müller-Dornieden, A. ; Körber, W. ; Marten-Engelke, K. ; Roedel, R. ; Christiansen, H. ; Engelke, C.</creator><creatorcontrib>Wolff, H.A. ; Wolff, C.R.M. ; Hess, C.F. ; Jung, K. ; Sennhenn-Kirchner, S. ; Hinterthaner, M. ; Müller-Dornieden, A. ; Körber, W. ; Marten-Engelke, K. ; Roedel, R. ; Christiansen, H. ; Engelke, C.</creatorcontrib><description>Background and purpose
Patients treated for squamous cell carcinoma of the head and neck (HNSCC) carry a high risk of second primary malignancies (SPM). Recently, computed tomography (CT) of the chest was shown to significantly decrease the risk of death due to bronchial carcinoma (BC) in a cohort of smokers whose risk of BC is increased but might be lower than that of patients previously treated for HNSCC. Thus, the present study evaluated the potential benefit of CT and other examinations in the detection of SPM in HNSCC patients.
Patients and methods
Between July 2008 and November 2011, 118 participants underwent a prospective, systematic examination for SPM (13 women, 105 men, median age 62 years). All patients had been previously treated for HNSCC and showed no recurrence or distant metastases at the time of the study start. CT scans, ear–nose–throat endoscopy, and endoscopy of the esophagus and stomach were performed.
Results
Overall, 33 suspicious findings were clarified by additional investigations. In all, 26 SPM were confirmed in 21 of 118 patients (18 %; 10 lung, 7 HNSCC, 3 gastrointestinal, 1 renal). Eighteen of these 21 patients (86 %) underwent therapy with curative intent.
Conclusion
The examinations revealed a high prevalence of curable stage SPM in HNSCC patients. Adapting a surveillance scheme including a chest CT is recommended.</description><identifier>ISSN: 0179-7158</identifier><identifier>EISSN: 1439-099X</identifier><identifier>DOI: 10.1007/s00066-013-0404-4</identifier><identifier>PMID: 23842636</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - radiotherapy ; Germany - epidemiology ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - radiotherapy ; Humans ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasms, Multiple Primary - mortality ; Neoplasms, Multiple Primary - radiotherapy ; Oncology ; Original Article ; Prevalence ; Radiotherapy ; Radiotherapy, Conformal - mortality ; Risk Assessment ; Squamous Cell Carcinoma of Head and Neck ; Survival Rate ; Treatment Outcome</subject><ispartof>Strahlentherapie und Onkologie, 2013-10, Vol.189 (10), p.874-880</ispartof><rights>Springer Heidelberg Berlin 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c324t-629a799e291acfc2078df2291510dc436498a14f404dc1cabf27364230af77453</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00066-013-0404-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00066-013-0404-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23842636$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wolff, H.A.</creatorcontrib><creatorcontrib>Wolff, C.R.M.</creatorcontrib><creatorcontrib>Hess, C.F.</creatorcontrib><creatorcontrib>Jung, K.</creatorcontrib><creatorcontrib>Sennhenn-Kirchner, S.</creatorcontrib><creatorcontrib>Hinterthaner, M.</creatorcontrib><creatorcontrib>Müller-Dornieden, A.</creatorcontrib><creatorcontrib>Körber, W.</creatorcontrib><creatorcontrib>Marten-Engelke, K.</creatorcontrib><creatorcontrib>Roedel, R.</creatorcontrib><creatorcontrib>Christiansen, H.</creatorcontrib><creatorcontrib>Engelke, C.</creatorcontrib><title>Second primary malignancies in head and neck cancer patients: High prevalence of curable-stage disease</title><title>Strahlentherapie und Onkologie</title><addtitle>Strahlenther Onkol</addtitle><addtitle>Strahlenther Onkol</addtitle><description>Background and purpose
Patients treated for squamous cell carcinoma of the head and neck (HNSCC) carry a high risk of second primary malignancies (SPM). Recently, computed tomography (CT) of the chest was shown to significantly decrease the risk of death due to bronchial carcinoma (BC) in a cohort of smokers whose risk of BC is increased but might be lower than that of patients previously treated for HNSCC. Thus, the present study evaluated the potential benefit of CT and other examinations in the detection of SPM in HNSCC patients.
Patients and methods
Between July 2008 and November 2011, 118 participants underwent a prospective, systematic examination for SPM (13 women, 105 men, median age 62 years). All patients had been previously treated for HNSCC and showed no recurrence or distant metastases at the time of the study start. CT scans, ear–nose–throat endoscopy, and endoscopy of the esophagus and stomach were performed.
Results
Overall, 33 suspicious findings were clarified by additional investigations. In all, 26 SPM were confirmed in 21 of 118 patients (18 %; 10 lung, 7 HNSCC, 3 gastrointestinal, 1 renal). Eighteen of these 21 patients (86 %) underwent therapy with curative intent.
Conclusion
The examinations revealed a high prevalence of curable stage SPM in HNSCC patients. Adapting a surveillance scheme including a chest CT is recommended.</description><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - radiotherapy</subject><subject>Germany - epidemiology</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Head and Neck Neoplasms - radiotherapy</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasms, Multiple Primary - mortality</subject><subject>Neoplasms, Multiple Primary - radiotherapy</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Prevalence</subject><subject>Radiotherapy</subject><subject>Radiotherapy, Conformal - mortality</subject><subject>Risk Assessment</subject><subject>Squamous Cell Carcinoma of Head and Neck</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><issn>0179-7158</issn><issn>1439-099X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kE1LxDAQhoMo7rr6A7xIwYuX6OSjSQNeZPELBA8qeAvZNF27tumatAf_vVm6igieQjLPvJl5EDomcE4A5EUEACEwEIaBA8d8B00JZwqDUq-7aApEKixJXkzQQYwrACK44vtoQlnBqWBiii6fnO18ma1D3ZrwmbWmqZfeeFu7mNU-e3OmzEwCvLPvmU0FF7K16Wvn-3iI9irTRHe0PWfo5eb6eX6HHx5v7-dXD9gyynssqDJSKUcVMbayFGRRVjTdcgKl5SwNVRjCq7RCaYk1i4rK9EgZmEpKnrMZOhtz16H7GFzsdVtH65rGeNcNURMuBJMMcpbQ0z_oqhuCT9MliuekEERuAslI2dDFGFylt_trAnqjVo9qdVKrN2o1Tz0n2-Rh0bryp-PbZQLoCMRU8ksXfn39b-oXKk2BHg</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Wolff, H.A.</creator><creator>Wolff, C.R.M.</creator><creator>Hess, C.F.</creator><creator>Jung, K.</creator><creator>Sennhenn-Kirchner, S.</creator><creator>Hinterthaner, M.</creator><creator>Müller-Dornieden, A.</creator><creator>Körber, W.</creator><creator>Marten-Engelke, K.</creator><creator>Roedel, R.</creator><creator>Christiansen, H.</creator><creator>Engelke, C.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FG</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20131001</creationdate><title>Second primary malignancies in head and neck cancer patients</title><author>Wolff, H.A. ; Wolff, C.R.M. ; Hess, C.F. ; Jung, K. ; Sennhenn-Kirchner, S. ; Hinterthaner, M. ; Müller-Dornieden, A. ; Körber, W. ; Marten-Engelke, K. ; Roedel, R. ; Christiansen, H. ; Engelke, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-629a799e291acfc2078df2291510dc436498a14f404dc1cabf27364230af77453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - radiotherapy</topic><topic>Germany - epidemiology</topic><topic>Head and Neck Neoplasms - mortality</topic><topic>Head and Neck Neoplasms - radiotherapy</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasms, Multiple Primary - mortality</topic><topic>Neoplasms, Multiple Primary - radiotherapy</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Prevalence</topic><topic>Radiotherapy</topic><topic>Radiotherapy, Conformal - mortality</topic><topic>Risk Assessment</topic><topic>Squamous Cell Carcinoma of Head and Neck</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wolff, H.A.</creatorcontrib><creatorcontrib>Wolff, C.R.M.</creatorcontrib><creatorcontrib>Hess, C.F.</creatorcontrib><creatorcontrib>Jung, K.</creatorcontrib><creatorcontrib>Sennhenn-Kirchner, S.</creatorcontrib><creatorcontrib>Hinterthaner, M.</creatorcontrib><creatorcontrib>Müller-Dornieden, A.</creatorcontrib><creatorcontrib>Körber, W.</creatorcontrib><creatorcontrib>Marten-Engelke, K.</creatorcontrib><creatorcontrib>Roedel, R.</creatorcontrib><creatorcontrib>Christiansen, H.</creatorcontrib><creatorcontrib>Engelke, C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Strahlentherapie und Onkologie</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wolff, H.A.</au><au>Wolff, C.R.M.</au><au>Hess, C.F.</au><au>Jung, K.</au><au>Sennhenn-Kirchner, S.</au><au>Hinterthaner, M.</au><au>Müller-Dornieden, A.</au><au>Körber, W.</au><au>Marten-Engelke, K.</au><au>Roedel, R.</au><au>Christiansen, H.</au><au>Engelke, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Second primary malignancies in head and neck cancer patients: High prevalence of curable-stage disease</atitle><jtitle>Strahlentherapie und Onkologie</jtitle><stitle>Strahlenther Onkol</stitle><addtitle>Strahlenther Onkol</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>189</volume><issue>10</issue><spage>874</spage><epage>880</epage><pages>874-880</pages><issn>0179-7158</issn><eissn>1439-099X</eissn><abstract>Background and purpose
Patients treated for squamous cell carcinoma of the head and neck (HNSCC) carry a high risk of second primary malignancies (SPM). Recently, computed tomography (CT) of the chest was shown to significantly decrease the risk of death due to bronchial carcinoma (BC) in a cohort of smokers whose risk of BC is increased but might be lower than that of patients previously treated for HNSCC. Thus, the present study evaluated the potential benefit of CT and other examinations in the detection of SPM in HNSCC patients.
Patients and methods
Between July 2008 and November 2011, 118 participants underwent a prospective, systematic examination for SPM (13 women, 105 men, median age 62 years). All patients had been previously treated for HNSCC and showed no recurrence or distant metastases at the time of the study start. CT scans, ear–nose–throat endoscopy, and endoscopy of the esophagus and stomach were performed.
Results
Overall, 33 suspicious findings were clarified by additional investigations. In all, 26 SPM were confirmed in 21 of 118 patients (18 %; 10 lung, 7 HNSCC, 3 gastrointestinal, 1 renal). Eighteen of these 21 patients (86 %) underwent therapy with curative intent.
Conclusion
The examinations revealed a high prevalence of curable stage SPM in HNSCC patients. Adapting a surveillance scheme including a chest CT is recommended.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23842636</pmid><doi>10.1007/s00066-013-0404-4</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0179-7158 |
| ispartof | Strahlentherapie und Onkologie, 2013-10, Vol.189 (10), p.874-880 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Aged Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - radiotherapy Germany - epidemiology Head and Neck Neoplasms - mortality Head and Neck Neoplasms - radiotherapy Humans Medicine Medicine & Public Health Middle Aged Neoplasms, Multiple Primary - mortality Neoplasms, Multiple Primary - radiotherapy Oncology Original Article Prevalence Radiotherapy Radiotherapy, Conformal - mortality Risk Assessment Squamous Cell Carcinoma of Head and Neck Survival Rate Treatment Outcome |
| title | Second primary malignancies in head and neck cancer patients: High prevalence of curable-stage disease |
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