Novel coumarin-3-carboxamides bearing N-benzylpiperidine moiety as potent acetylcholinesterase inhibitors

Some novel coumarin-3-carboxamide derivatives linked to N-benzylpiperidine scaffold were synthesized and evaluated as acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitors. The screening results showed that most of compounds exhibited potent anti-AChE activity in the range of nM c...

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Veröffentlicht in:	European journal of medicinal chemistry 2013-12, Vol.70, p.623-630
Hauptverfasser:	Asadipour, Ali, Alipour, Masoumeh, Jafari, Mona, Khoobi, Mehdi, Emami, Saeed, Nadri, Hamid, Sakhteman, Amirhossein, Moradi, Alireza, Sheibani, Vahid, Homayouni Moghadam, Farshad, Shafiee, Abbas, Foroumadi, Alireza
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholinesterase Acetylcholinesterase - metabolism Alzheimer's disease Amides - chemical synthesis Amides - chemistry Amides - pharmacology Animals Butyrylcholinesterase Butyrylcholinesterase - blood Butyrylcholinesterase - metabolism Cholinesterase Inhibitors - chemical synthesis Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - pharmacology Coumarin Coumarins - chemistry Coumarins - pharmacology Docking Dose-Response Relationship, Drug Electrophorus Horses Kinetic study Models, Molecular Molecular Structure N-Benzylpiperidine Piperidines - chemistry Structure-Activity Relationship
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