Imported loiasis in France: A retrospective analysis of 47 cases
Summary Background French physicians occasionally encounter travelers (immigrants, expatriates, others) seeking care for loiasis. Methods We describe the clinical and biological patterns and treatment of 47 cases of imported loiasis seen at three French hospitals over a 15-year period (1998–2012). R...
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| Veröffentlicht in: | Travel medicine and infectious disease 2013-11, Vol.11 (6), p.366-373 |
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| creator | Gantois, Natacha Rapp, Christophe Gautret, Philippe Ficko, Cécile Savini, Hélène Larreché, Sébastien Saidi, Redouan Crevon, Lionel Simon, Fabrice |
| description | Summary Background French physicians occasionally encounter travelers (immigrants, expatriates, others) seeking care for loiasis. Methods We describe the clinical and biological patterns and treatment of 47 cases of imported loiasis seen at three French hospitals over a 15-year period (1998–2012). Results Most patients acquired their infection in Cameroon, Gabon, and Central African Republic. Overall, Calabar swellings were observed in 63% patients, and eye worm migration in 29%. Peripheral blood microfilariae were detected in 48% of patients and eosinophilia in 90% respectively. Calabar swellings and eosinophilia were more common among expatriates and travelers, whereas African immigrants were more likely to present with eye worm migration and have microfilaremia. First-line treatment was ivermectin in most cases (51%), followed by diethylcarbamazine (23%), albendazole (8%) or a combination of drugs (8%). Forty-one patients underwent clinical and parasitological follow-up for a mean period of 422 days [range 30–3600 days]. Clinical relapse and/or persistence/reappearance of blood microfilaria occurred in 10 patients. Conclusions Clinical and biological features were comparable with the largest monocentric series of imported loiasis. There was a marked rate of failure after first-line treatment and rare adverse effects were reported. The treatment of patients with imported loiasis would benefit from standardization with guidelines for the choice of first and second line drugs, the length of follow-up and criteria for cure. |
| doi_str_mv | 10.1016/j.tmaid.2013.08.005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1465866725</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1477893913001336</els_id><sourcerecordid>1465866725</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-b0a5422ff8daa84e4047a650d11123101062cabe8f7747a0e2afcb118142eecc3</originalsourceid><addsrcrecordid>eNqFkU1LAzEQhoMoWqu_QJAFL152nXzsbiooluIXCB7Uc0izs5C6HzXZFvrvzbZVoRdPGcgzk7zPEHJGIaFAs6tZ0tXaFgkDyhOQCUC6RwZU5jwGIdh-qEWex3LER0fk2PsZAE-l4IfkiIlQZkIOyN1zPW9dh0VUtVZ76yPbRA9ONwavo3HksHOtn6Pp7BIj3ehq1TNtGYk8MtqjPyEHpa48nm7PIfl4uH-fPMUvr4_Pk_FLbFKQXTwFnQrGylIWWkuBAkSusxQKSinjIQ9kzOgpyjLPww0g06WZUiqpYIjG8CG53Mydu_Zrgb5TtfUGq0o32C68oiJLZZblLA3oxQ46axcu_H1NieADaE_xDWVCQu-wVHNna-1WioLqBauZWgtWvWAFUgXBoet8O3sxrbH47fkxGoCbDYBBxtKiU95YDDoL64JGVbT2nwdud_pNZRtrdPWJK_R_SZRnCtRbv-N-xZRDmMIz_g1895-K</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1464939015</pqid></control><display><type>article</type><title>Imported loiasis in France: A retrospective analysis of 47 cases</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Gantois, Natacha ; Rapp, Christophe ; Gautret, Philippe ; Ficko, Cécile ; Savini, Hélène ; Larreché, Sébastien ; Saidi, Redouan ; Crevon, Lionel ; Simon, Fabrice</creator><creatorcontrib>Gantois, Natacha ; Rapp, Christophe ; Gautret, Philippe ; Ficko, Cécile ; Savini, Hélène ; Larreché, Sébastien ; Saidi, Redouan ; Crevon, Lionel ; Simon, Fabrice</creatorcontrib><description>Summary Background French physicians occasionally encounter travelers (immigrants, expatriates, others) seeking care for loiasis. Methods We describe the clinical and biological patterns and treatment of 47 cases of imported loiasis seen at three French hospitals over a 15-year period (1998–2012). Results Most patients acquired their infection in Cameroon, Gabon, and Central African Republic. Overall, Calabar swellings were observed in 63% patients, and eye worm migration in 29%. Peripheral blood microfilariae were detected in 48% of patients and eosinophilia in 90% respectively. Calabar swellings and eosinophilia were more common among expatriates and travelers, whereas African immigrants were more likely to present with eye worm migration and have microfilaremia. First-line treatment was ivermectin in most cases (51%), followed by diethylcarbamazine (23%), albendazole (8%) or a combination of drugs (8%). Forty-one patients underwent clinical and parasitological follow-up for a mean period of 422 days [range 30–3600 days]. Clinical relapse and/or persistence/reappearance of blood microfilaria occurred in 10 patients. Conclusions Clinical and biological features were comparable with the largest monocentric series of imported loiasis. There was a marked rate of failure after first-line treatment and rare adverse effects were reported. The treatment of patients with imported loiasis would benefit from standardization with guidelines for the choice of first and second line drugs, the length of follow-up and criteria for cure.</description><identifier>ISSN: 1477-8939</identifier><identifier>EISSN: 1873-0442</identifier><identifier>DOI: 10.1016/j.tmaid.2013.08.005</identifier><identifier>PMID: 24035648</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Drug dosages ; Enzymes ; Expatriates ; Female ; France - epidemiology ; Hepatitis ; Humans ; Immigrants ; Imported ; Infectious Disease ; Ivermectin ; Loa loa ; Loiasis ; Loiasis - diagnosis ; Loiasis - drug therapy ; Loiasis - epidemiology ; Male ; Medical treatment ; Middle Aged ; Military personnel ; Parasites ; Parasitic diseases ; Patients ; Retrospective Studies ; Skin ; Skin diseases ; Studies ; Teaching hospitals ; Tourism ; Travel ; Travel - statistics & numerical data ; Travel medicine ; Tropical diseases ; Young Adult</subject><ispartof>Travel medicine and infectious disease, 2013-11, Vol.11 (6), p.366-373</ispartof><rights>Elsevier Ltd</rights><rights>2013 Elsevier Ltd</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Nov - Dec 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-b0a5422ff8daa84e4047a650d11123101062cabe8f7747a0e2afcb118142eecc3</citedby><cites>FETCH-LOGICAL-c508t-b0a5422ff8daa84e4047a650d11123101062cabe8f7747a0e2afcb118142eecc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1477893913001336$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24035648$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gantois, Natacha</creatorcontrib><creatorcontrib>Rapp, Christophe</creatorcontrib><creatorcontrib>Gautret, Philippe</creatorcontrib><creatorcontrib>Ficko, Cécile</creatorcontrib><creatorcontrib>Savini, Hélène</creatorcontrib><creatorcontrib>Larreché, Sébastien</creatorcontrib><creatorcontrib>Saidi, Redouan</creatorcontrib><creatorcontrib>Crevon, Lionel</creatorcontrib><creatorcontrib>Simon, Fabrice</creatorcontrib><title>Imported loiasis in France: A retrospective analysis of 47 cases</title><title>Travel medicine and infectious disease</title><addtitle>Travel Med Infect Dis</addtitle><description>Summary Background French physicians occasionally encounter travelers (immigrants, expatriates, others) seeking care for loiasis. Methods We describe the clinical and biological patterns and treatment of 47 cases of imported loiasis seen at three French hospitals over a 15-year period (1998–2012). Results Most patients acquired their infection in Cameroon, Gabon, and Central African Republic. Overall, Calabar swellings were observed in 63% patients, and eye worm migration in 29%. Peripheral blood microfilariae were detected in 48% of patients and eosinophilia in 90% respectively. Calabar swellings and eosinophilia were more common among expatriates and travelers, whereas African immigrants were more likely to present with eye worm migration and have microfilaremia. First-line treatment was ivermectin in most cases (51%), followed by diethylcarbamazine (23%), albendazole (8%) or a combination of drugs (8%). Forty-one patients underwent clinical and parasitological follow-up for a mean period of 422 days [range 30–3600 days]. Clinical relapse and/or persistence/reappearance of blood microfilaria occurred in 10 patients. Conclusions Clinical and biological features were comparable with the largest monocentric series of imported loiasis. There was a marked rate of failure after first-line treatment and rare adverse effects were reported. The treatment of patients with imported loiasis would benefit from standardization with guidelines for the choice of first and second line drugs, the length of follow-up and criteria for cure.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Drug dosages</subject><subject>Enzymes</subject><subject>Expatriates</subject><subject>Female</subject><subject>France - epidemiology</subject><subject>Hepatitis</subject><subject>Humans</subject><subject>Immigrants</subject><subject>Imported</subject><subject>Infectious Disease</subject><subject>Ivermectin</subject><subject>Loa loa</subject><subject>Loiasis</subject><subject>Loiasis - diagnosis</subject><subject>Loiasis - drug therapy</subject><subject>Loiasis - epidemiology</subject><subject>Male</subject><subject>Medical treatment</subject><subject>Middle Aged</subject><subject>Military personnel</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Skin</subject><subject>Skin diseases</subject><subject>Studies</subject><subject>Teaching hospitals</subject><subject>Tourism</subject><subject>Travel</subject><subject>Travel - statistics & numerical data</subject><subject>Travel medicine</subject><subject>Tropical diseases</subject><subject>Young Adult</subject><issn>1477-8939</issn><issn>1873-0442</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkU1LAzEQhoMoWqu_QJAFL152nXzsbiooluIXCB7Uc0izs5C6HzXZFvrvzbZVoRdPGcgzk7zPEHJGIaFAs6tZ0tXaFgkDyhOQCUC6RwZU5jwGIdh-qEWex3LER0fk2PsZAE-l4IfkiIlQZkIOyN1zPW9dh0VUtVZ76yPbRA9ONwavo3HksHOtn6Pp7BIj3ehq1TNtGYk8MtqjPyEHpa48nm7PIfl4uH-fPMUvr4_Pk_FLbFKQXTwFnQrGylIWWkuBAkSusxQKSinjIQ9kzOgpyjLPww0g06WZUiqpYIjG8CG53Mydu_Zrgb5TtfUGq0o32C68oiJLZZblLA3oxQ46axcu_H1NieADaE_xDWVCQu-wVHNna-1WioLqBauZWgtWvWAFUgXBoet8O3sxrbH47fkxGoCbDYBBxtKiU95YDDoL64JGVbT2nwdud_pNZRtrdPWJK_R_SZRnCtRbv-N-xZRDmMIz_g1895-K</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Gantois, Natacha</creator><creator>Rapp, Christophe</creator><creator>Gautret, Philippe</creator><creator>Ficko, Cécile</creator><creator>Savini, Hélène</creator><creator>Larreché, Sébastien</creator><creator>Saidi, Redouan</creator><creator>Crevon, Lionel</creator><creator>Simon, Fabrice</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H95</scope><scope>H97</scope><scope>K9.</scope><scope>KB0</scope><scope>L.G</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20131101</creationdate><title>Imported loiasis in France: A retrospective analysis of 47 cases</title><author>Gantois, Natacha ; Rapp, Christophe ; Gautret, Philippe ; Ficko, Cécile ; Savini, Hélène ; Larreché, Sébastien ; Saidi, Redouan ; Crevon, Lionel ; Simon, Fabrice</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-b0a5422ff8daa84e4047a650d11123101062cabe8f7747a0e2afcb118142eecc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Drug dosages</topic><topic>Enzymes</topic><topic>Expatriates</topic><topic>Female</topic><topic>France - epidemiology</topic><topic>Hepatitis</topic><topic>Humans</topic><topic>Immigrants</topic><topic>Imported</topic><topic>Infectious Disease</topic><topic>Ivermectin</topic><topic>Loa loa</topic><topic>Loiasis</topic><topic>Loiasis - diagnosis</topic><topic>Loiasis - drug therapy</topic><topic>Loiasis - epidemiology</topic><topic>Male</topic><topic>Medical treatment</topic><topic>Middle Aged</topic><topic>Military personnel</topic><topic>Parasites</topic><topic>Parasitic diseases</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>Skin</topic><topic>Skin diseases</topic><topic>Studies</topic><topic>Teaching hospitals</topic><topic>Tourism</topic><topic>Travel</topic><topic>Travel - statistics & numerical data</topic><topic>Travel medicine</topic><topic>Tropical diseases</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gantois, Natacha</creatorcontrib><creatorcontrib>Rapp, Christophe</creatorcontrib><creatorcontrib>Gautret, Philippe</creatorcontrib><creatorcontrib>Ficko, Cécile</creatorcontrib><creatorcontrib>Savini, Hélène</creatorcontrib><creatorcontrib>Larreché, Sébastien</creatorcontrib><creatorcontrib>Saidi, Redouan</creatorcontrib><creatorcontrib>Crevon, Lionel</creatorcontrib><creatorcontrib>Simon, Fabrice</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Travel medicine and infectious disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gantois, Natacha</au><au>Rapp, Christophe</au><au>Gautret, Philippe</au><au>Ficko, Cécile</au><au>Savini, Hélène</au><au>Larreché, Sébastien</au><au>Saidi, Redouan</au><au>Crevon, Lionel</au><au>Simon, Fabrice</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Imported loiasis in France: A retrospective analysis of 47 cases</atitle><jtitle>Travel medicine and infectious disease</jtitle><addtitle>Travel Med Infect Dis</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>11</volume><issue>6</issue><spage>366</spage><epage>373</epage><pages>366-373</pages><issn>1477-8939</issn><eissn>1873-0442</eissn><abstract>Summary Background French physicians occasionally encounter travelers (immigrants, expatriates, others) seeking care for loiasis. Methods We describe the clinical and biological patterns and treatment of 47 cases of imported loiasis seen at three French hospitals over a 15-year period (1998–2012). Results Most patients acquired their infection in Cameroon, Gabon, and Central African Republic. Overall, Calabar swellings were observed in 63% patients, and eye worm migration in 29%. Peripheral blood microfilariae were detected in 48% of patients and eosinophilia in 90% respectively. Calabar swellings and eosinophilia were more common among expatriates and travelers, whereas African immigrants were more likely to present with eye worm migration and have microfilaremia. First-line treatment was ivermectin in most cases (51%), followed by diethylcarbamazine (23%), albendazole (8%) or a combination of drugs (8%). Forty-one patients underwent clinical and parasitological follow-up for a mean period of 422 days [range 30–3600 days]. Clinical relapse and/or persistence/reappearance of blood microfilaria occurred in 10 patients. Conclusions Clinical and biological features were comparable with the largest monocentric series of imported loiasis. There was a marked rate of failure after first-line treatment and rare adverse effects were reported. The treatment of patients with imported loiasis would benefit from standardization with guidelines for the choice of first and second line drugs, the length of follow-up and criteria for cure.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>24035648</pmid><doi>10.1016/j.tmaid.2013.08.005</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent Adult Aged Drug dosages Enzymes Expatriates Female France - epidemiology Hepatitis Humans Immigrants Imported Infectious Disease Ivermectin Loa loa Loiasis Loiasis - diagnosis Loiasis - drug therapy Loiasis - epidemiology Male Medical treatment Middle Aged Military personnel Parasites Parasitic diseases Patients Retrospective Studies Skin Skin diseases Studies Teaching hospitals Tourism Travel Travel - statistics & numerical data Travel medicine Tropical diseases Young Adult |
| title | Imported loiasis in France: A retrospective analysis of 47 cases |
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