Modification of a Designed Amphipathic Cell-Penetrating Peptide and Its Effect on Solubility, Secondary Structure, and Uptake Efficiency

The development of safe and efficient nonviral gene delivery carriers has received a great deal of attention in the past decade. A class of amphipathic peptides has shown to be able to cross cell membranes and deliver cargo to the intracellular environment. Here, we introduce an 18-mer amphipathic p...

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Veröffentlicht in:	Biochemistry (Easton) 2013-05, Vol.52 (20), p.3428-3435
Hauptverfasser:	Jafari, Mousa, Karunaratne, D. Nedra, Sweeting, Chad M, Chen, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell-Penetrating Peptides - chemistry Cell-Penetrating Peptides - metabolism CHO Cells Circular Dichroism Cricetinae Cricetulus Mesylates - chemistry Mesylates - metabolism Protein Structure, Secondary RNA, Small Interfering - chemistry RNA, Small Interfering - metabolism Solubility Spectroscopy, Fourier Transform Infrared Surface Tension
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